Jegyeong Ryu
Seoul National University
研究室紹介
Professor Jegyeong Ryu's research lab specializes in single-molecule biophysics and molecular mechanisms underlying chromosome organization and intracellular membrane trafficking. The lab investigates how ring-shaped SMC complexes like cohesin and condensin extrude DNA loops to shape chromatin architecture, with a focus on their ability to translocate through protein-bound DNA and large macromolecular complexes. Additionally, the lab explores the mechanochemical mechanisms of AAA+ ATPases, such as NSF, in disassembling SNARE complexes during membrane fusion. Using advanced single-molecule imaging and force spectroscopy techniques, the lab uncovers fundamental principles of biomolecular condensation, loop extrusion, and protein complex disassembly.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
1This dataset contains the time-lapse imaging data collected and analyzed in "In vitro reconstitution of heterochromatin compartments reveals the spontaneous formation of tunable liquid-liquid interfaces." These movies include representative droplet fusions and heat-reversibility of chromatin compartmentalization, the quantification of which is shown in Figures 2, 3, and 4 of the manuscript. The Python scripts used to analyze and visualize this data are included in the PythonNotebooks.zip folder.