Ji Hye Park
Yonsei University · 医学
研究室紹介
Professor Ji Hye Park's research lab focuses on the complex interplay between the gut microbiota, chronic inflammatory diseases, and gastrointestinal malignancies, with a particular emphasis on inflammatory bowel diseases (IBD) and colorectal cancer (CRC). The lab investigates microbial dysbiosis, host-microbe interactions, and the role of microbial extracellular vesicles in disease pathogenesis, aiming to uncover novel diagnostic and therapeutic targets. Research also extends to hepatobiliary diseases, especially HBV-related cirrhosis, where renal safety of antiviral therapies is evaluated. The lab integrates clinical epidemiology with molecular microbiology to advance precision medicine in gastrointestinal disorders.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the gastrointestinal tract caused by interactions between genetic, environmental, immunological, and microbial factors. While the incidence and prevalence of IBD in Asian populations were relatively lower than those in Western countries, they appear to be gradually increasing. A Westernized diet, high socioeconomic status, improvement of hygiene, and development of
The human microbiota comprises trillions of microbes, and the relationship between cancer and microbiota is very complex. The impact of fecal microbiota alterations on colorectal cancer (CRC) pathogenesis is emerging. This study analyzed changes in the microbial composition in CRC subjects with both fecal microbiota and gut microbe-derived extracellular vesicles (EVs). From August 2017 to August 2018, 70 CRC patients and 158 control subjects were enrolled in the study. Metagenomic profiling of f
The incidence and prevalence of inflammatory bowel diseases (IBDs) are rapidly increasing worldwide. IBDs are considered an emerging problem not only in Western countries but also in developing counties. The relapses and complications of active IBD mandate various medications. Nevertheless, hospitalization, emergency room visits, or surgery may be required, resulting in a socioeconomic burden. Great advances have been made in the development of new therapeutic options for IBD to achieve inductio
In patients with HBV-related cirrhosis, TDF has shown similar renal safety to that of ETV over a 2-year period. Renal function should be closely monitored, especially in patients who exhibit decreasing eGFR, DM, and the use of diuretics.
The incidence and prevalence rates of inf lammatory bowel disease (IBD) have been increasing in East Asian countries over the past few decades. Accordingly, the general understanding and awareness of IBD among healthcare professionals has increased considerably in this region. This increase is ultimately associated with the evolving focus of IBD clinicians devoted to comprehensive patient care, especially in establishing IBD clinics/centers capable of providing multidisciplinary counseling. Comp
Elevated resting heart rate was independently associated with a higher rate of advanced adenoma recurrence in colorectal cancer survivors.
Abstract We aimed to identify the effects of physical activity and body composition on colorectal polyp recurrence in patients with previous colorectal cancer. A total of 300 patients were selected randomly from the colorectal cancer survivor cohort of Severance Hospital (Seoul, Korea). Patients reported various recreational physical activities and received surveillance colonoscopy. Body composition was measured with a body composition analyzer. We compared patients who exercised for at least 1
Higher disease-related knowledge could reduce the requirement of step-up therapy in IBD. The IBD-KNOW score was independently predictive of step-up therapy.
Acute respiratory distress syndrome (ARDS) is a medical emergency that threatens life. To this day, ARDS is very rarely reported by iodine contrast media, and there is no reported case of ARDS induced by gadolinium contrast media. Here, we present a case with ARDS after the use of gadobutrol (Gadovist) as a magnetic resonance imaging (MRI) contrast medium. A 26 years old female without any medical history, including allergic diseases and without current use of drugs, visited the emergency room f
본 연구의 목적은 한국 고등학생의 비만도와 체육수업 참여가 정신건강에 미치는 영향을 알아보는 데 있다. 본 연구를 위하여 서울과 경기 소재의 고등학교 2학년 학생 중 체육 수업에 참여하는 1458명과 체육수업에 참여하지 않는 1287명 총 2745명(남:1157명, 여자:1588명)의 정신건강을 SCL-90R 설문지를 통하여 분석하였다. 통계 분석을 위하여 Windows용 SPSS 12.0 version을 사용하였으며 목적에 맞게 T-검정 그리고 ANOVA를 실시하였다. 결과를 요약하면 다음 과 같다. 첫째, 비만하지 않은 학생이 비만한 학생에 비해 정신건강이 유의하게 좋은 것으로 나타났다. 둘째, 체육수업에 참여하는 남-여 학생에서 체육 수업에 참여하지 않는 학생에 비해 정신건강이 유의하게 좋은 것으로 나타났다. 셋째, 체육수업에 참여하는 학생들이 참여하지 않는 학생들에 비해 비만도가 약간 낮았지만 통계적으로 유의한 차이는 나타나지 않았다. 본 연구는 청소년의 체육수업 참여가 정신
Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor-α, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness f