Ji-Hyeon Choi
Yonsei University · 医学
研究室紹介
Professor Ji-Hyeon Choi's research lab focuses on the molecular mechanisms of cellular stress responses, particularly endoplasmic reticulum (ER) stress, and its implications in inflammatory diseases, neurodegeneration, and metabolic disorders. The lab investigates the therapeutic potential of natural compounds and microbial-derived vesicles—such as *Lactobacillus paracasei*-derived extracellular vesicles and baicalein—in modulating ER stress and inflammation. Using in vitro cell models and in vivo animal models (e.g., colitis and obesity models), the lab explores cytoprotective and anti-inflammatory effects, with a strong emphasis on oxidative stress, mitochondrial function, and immune modulation. Additionally, the lab extends into translational and behavioral research, examining how voice characteristics in smart society contexts influence human perception and emotional response.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Lactobacillus paracasei is a major probiotic and is well known for its anti-inflammatory properties. Thus, we investigated the effects of L. paracasei-derived extracellular vesicles (LpEVs) on LPS-induced inflammation in HT29 human colorectal cancer cells and dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. ER stress inhibitors (salubrinal or 4-PBA) or CHOP siRNA were utilized to investigate the relationship between LpEV-induced endoplasmic reticulum (ER) stress and the inhibitory e
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and cerebral ischemia, we investigated the effects of baicalein on apoptotic death of HT22 mouse hippocampal neuronal cells induced by thapsigargin (TG) and brefeldin A (BFA), two representative ER stres
The epithelial cytokine response, associated with reactive oxygen species (ROS), is important in Helicobacter pylori (H. pylori)-induced inflammation. H. pylori induces the production of ROS, which may be involved in the activation of mitogen-activated protein kinases (MAPK), janus kinase/signal transducers and activators of transcription (Jak/Stat), and oxidant-sensitive transcription factor, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and thus, expression of interle
Obesity is a medical condition in which excess body fat has accumulated to a serious extent. It is a chronic disease that can lead to dyslipidemia, insulin resistance, and type 2 diabetes. In the present study, we investigated the anti-obesity effects of <i>Sicyos angulatus</i> (SA) extract on a high-fat diet (HFD)-induced C57BL/6J obese mice. The mice were divided into vehicle and three SA groups (25, 50, and 100 mg/kg body weight). The mice were fed a HFD with or without SA for 12 weeks. The o
Uterine fibroid, or leiomyoma, is a common benign neoplasm in women, but serious complications are rarely reported. We present the case of a 48-year-old woman with acute onset of abdominal pain. She was hemodynamically unstable, and computed tomography revealed abundant fluid collection in the peritoneal cavity, suggesting hemoperitoneum. During emergency exploratory laparotomy, the subserosal vein overlying a uterine fibroid was identified as the source of bleeding. Hemostasis was accomplished
현재와 같은 스마트 사회는 ICT 기술 및 통신 인프라 등의 발달로 말미암아 청자들이 느끼는 호감 있는 목소리가 과거와 달리 변하고 있다. 즉, 과거에는 크고, 강하고, 빠른 목소리를 호감 있는 목소리로 여겼다면 지금은 ICT 기술과 더불어 새로운 사회 문화가 이를 변화시키고 있다. 그러면 이제는 '현재와 같은 스마트 사회에서 어떤 목소리가 호감을 느끼는 목소리일까?'를 규명해 내는 것이 중요한 일 중 하나가 된다. 이를 위해 본 논문에서는 ICT 기술을 적용하여 청자들이 호감을 느끼는 목소리는 과연 어떤 목소리인지를 규명하였다. 연구는 크게 두 가지로 나누어 진행하였다. 첫째, 언어에 있어 소통과 관련된 요소들, 특히 정서적 기반의 말들이 실제 청자들의 호감도에 미치는 영향에 대한 실증 분석 작업을 정량화된 수치로 추출하였다. 이를 위해 일반인을 대상으로 한 실험을 행하였다. 둘째, 청자들이 호감을 느끼는 음성은 어떤 음성인지를 규명해 내는 작업을 수행하였다. 이를 위해 실제 사회
Zn(O,S) thin films were successfully deposited by reactive sputtering using Ar and O2 gas mixtures at 473 K. X-ray diffraction patterns revealed that the well crystallized Zn(O,S) films were deposited with increasing oxygen concentration in O2/Ar, resulting in a shift of the Zn peak of 28.5° to a higher angle, closer to the ZnO peak of 34.4°. Zn(O,S) films were composed of grains agglomerated from small particles, which grew gradually with increasing oxygen concentration. The depth profiles and
이 연구의 목적은 키워드 네트워크 분석을 활용하여 ‘인공지능인문학’의 연구 동향을 확인하는 데 있다. 인공지능인문학은 단순히 인공지능과 인문학의 융합이 아니다. 인문학의 관점에서 인공지능 시대를 해석하고, 인공지능 기술을 활용하여 사회를 분석하고자 하는 융합적 학문 분야이다. 인공지능인문학을 시작하고 연구해 온 중앙대학교 인문콘텐츠연구소 구성원의 연구 성과 중심으로 그 성과들을 인용한 논문과의 관계 속에서 연구 영향성을 파악하고자 키워드 네트워크 분석을 실시하였다. 인공지능인문학의 5개 연구영역인 관계소통학, 기술비평학, 데이터해석학, 사회문화학, 윤리규범학에 교육학 분야를 추가하여 총 6개 연구영역에서의 고빈도 어휘를 추출한 결과 관계소통학에서는 ‘메타버스, AI, 교육, 가상, 공공언어, 한국어’가, 기술 비평학에서는 ‘AI, 포스트휴먼, 디지털, 교육, 기술, 로봇’이, 데이터해석학에서는 ‘AI, machine learning, 교육, 텍스트 마이닝, 빅데이터, 언어 네트워크’
Abstract Mouse models expressing human ACE2 for coronavirus disease 2019 have been frequently used to understand its pathogenesis and develop therapeutic strategies against SARS-CoV-2. Given that human TMPRSS2 supports viral entry, replication, and pathogenesis, we established a double-transgenic mouse model expressing both human ACE2 and TMPRSS2 for SARS-CoV-2 infection. Co-overexpression of both genes increased viral infectivity in vitro and in vivo. Notably, double-transgenic mice showed sign