Ji Soo Park
Seoul National University · 医学
研究室紹介
Professor Ji Soo Park's research lab focuses on translational biomedical research with a strong emphasis on respiratory diseases, genetic susceptibility in cancer, and pediatric health outcomes. The lab investigates the molecular mechanisms of environmental toxicants on lung epithelial cells, particularly polyhexamethylene guanidine phosphate (PHMG-p), and explores genetic variants associated with hereditary cancers using multigene panel sequencing. Additionally, the lab applies machine learning and health data analytics to improve pediatric respiratory disease diagnosis and evaluate medication safety in children and adolescents.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Polyhexamethylene guanidine phosphate (PHMG-p) is an active ingredient of humidifier disinfectants and causes severe lung injury resulting in pulmonary fibrosis. Current evidence indicates that pulmonary fibrosis is initiated as a result of epithelial damage, which can lead to an inflammatory response and fibrotic cell infiltration; however, the toxic mechanism of PHMG-p on the epithelium is still unknown. In this study, the toxic response of PHMG-p on human lung epithelial cells was evaluated,
Auscultation, a cost-effective and non-invasive part of physical examination, is essential to diagnose pediatric respiratory disorders. Electronic stethoscopes allow transmission, storage, and analysis of lung sounds. We aimed to develop a machine learning model to classify pediatric respiratory sounds. Lung sounds were digitally recorded during routine physical examinations at a pediatric pulmonology outpatient clinic from July to November 2019 and labeled as normal, crackles, or wheezing. Ense
PURPOSE: Comparison of variant frequencies in the general population has become an essential part of the American College of Medical Genetics and Genomics (ACMG) standards and guidelines for interpreting sequence variants. We determined the optimal number of relevant ethnic controls that should be used to accurately calculate the odds ratio (OR) of genetic variants. MATERIALS AND METHODS: Using the ACMG guidelines, we reclassified BRCA1 and BRCA2 mutations and variants of unknown significance in
BACKGROUND: Leukotriene receptor antagonists (LTRAs) are widely used for asthma and allergic rhinitis (AR), but concerns about the risk of neuropsychiatric events (NPEs) have been raised since the first Drug Safety Communication by the US Food and Drug Administration in 2008. This study evaluates the association between LTRA use and NPEs in children, adolescents and young adults with asthma or AR. METHODS: A self-controlled case series study was conducted using the Korean National Health Insuran
BACKGROUND: We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of cancer susceptibility genes in BRCA1/2 mutation-negative Korean patients with a high risk for hereditary breast cancer using a comprehensive multigene panel that included 35 cancer susceptibility genes. METHODS: Samples from 120 patients who were negative for BRCA1/2 mutations, but had been diagnosed with breast cancer that was likely hereditary, were prospectively evaluated for the prevalence of
다문화청소년의 수가 지속적으로 증가 추세에 있지만 이들은 사회적 관심에서 상대적으로 소외되어 왔다. 한국 사회에서 다문화청소년들이 겪는 어려움은 비행 행동으로 표출될 가능성이 있음에도, 특히 이들의 비행 행동에 대한 이론적 고찰과 비행유형별 접근이 수반된 연구가 부족한 실정이다. 이에 본 연구는 일반긴장이론, 사회유대이론, 사회학습이론을 바탕으로 이론에서 제시하는 비행 요인들이 다문화청소년의 지위비행과 중비행에 끼치는 영향을 살펴보고자 하였다. 본 연구에서는 한국청소년정책연구원에서 실시한 다문화청소년패널 4차년도 자료인 중학교 1학년 학생 1,360명의 데이터를 대상으로 로지스틱 회귀분석을 실시하여 이론적 예측요인과 유형별 관계를 예측하고자 하였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 지위비행의 경우 긴장요인, 사회유대요인, 사회학습 요인 모두가 영향을 주는 것으로 나타났다. 둘째, 중비행의 경우에는 사회유대요인 및 사회학습요인이 유의한 영향을 주는 것으로 나타났다. 이와