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Ji Won Jang

Korea University · 神経科学

研究室紹介

Professor Ji Won Jang's research lab focuses on auditory and vestibular health, with a primary emphasis on understanding the pathophysiology of hearing loss, dizziness, and ototoxicity. The lab investigates the impact of environmental and lifestyle factors—such as smoking, e-cigarette use, and ototoxic drugs—on hearing and balance disorders, using both human cell models and zebrafish as in vivo models. A key research direction involves exploring protective agents, including trimetazidine and sodium selenite, against drug-induced ototoxicity through oxidative stress modulation. The lab also contributes to improving early detection and management of hearing impairment in high-risk populations, particularly neonates in the NICU.

ototoxicityhearing lossdizzinesse-cigaretteszebrafish models

Research Overview

Papers
128
Total Citations
1,338
Papers (5y)
30
Primary Field
神経科学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
30total
2021
2022
2023
2024
2025
Citations per year (5y)
144total
20212022202320242025

Selected Papers

15
1
Article|67 citations·2016
Effect of Cigarette Smoking and Passive Smoking on Hearing Impairment: Data from a Population–Based Study
Jiwon Chang, Namhyung Ryou, Hyung Jin Jun, Soon Young Hwang, Jae‐Jun Song, Sung Won Chae
SJR Q1PLoS ONEOA

Current smoking was associated with hearing impairment in both speech-relevant frequency and high frequency across all ages. However, except in the ages of 40s, passive smoking was not related to hearing impairment in either speech-relevant or high frequencies.

Sensory SystemsNeuroscience
2
Article|60 citations·2013
Protective Effect of Metformin Against Cisplatin-Induced Ototoxicity in an Auditory Cell Line
Jiwon Chang, Hak Hyun Jung, Ji Yoon Yang, Sehee Lee, June Choi, Gi Jung Im, Sung Won Chae
SJR Q1Journal of the Association for Research in Otolaryngology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
Article|31 citations·2017
Prevalence of Dizziness and Associated Factors in South Korea: A Cross-Sectional Survey From 2010 to 2012
Jiwon Chang, Soon Young Hwang, Su Kyoung Park, Jin Hwan Kim, Hyung‐Jong Kim, Sung Won Chae, Jae‐Jun Song
SJR Q1Journal of EpidemiologyOA

In our study, the prevalence of dizziness in the general population was 20.10%. There was a stronger relationship between dizziness and physical performance, chronic diseases, and health behaviors compared to that with otologic diseases. Interventions for dizziness should be approached in a multifactorial manner and an understanding of various factors is necessary for the prevention and management of this condition.

NeurologyNeuroscience
4
Article|29 citations·2018
Effect of electronic cigarettes on human middle ear
Jae‐Jun Song, Yoon Young Go, Ji Yoen Mun, Sehee Lee, Gi Jung Im, Yoo yon Kim, Jun Ho Lee, Jiwon Chang
SJR Q2International Journal of Pediatric Otorhinolaryngology
PhysiologyMedicine
5
Article|27 citations·2020
Comparison between in vitro toxicities of tobacco- and menthol-flavored electronic cigarette liquids on human middle ear epithelial cells
Yoon Young Go, Ji Yoen Mun, Sung Won Chae, Jiwon Chang, Jae‐Jun Song
SJR Q1Scientific ReportsOA

Abstract Since electronic-cigarettes (e-cigarettes) are considered less toxic than conventional tobacco smoking, the use of e-cigarettes has increased, and the market for e-cigarette liquids (e-liquids) is continuously increasing. However, many studies showed that e-cigarettes may cause various harmful effects in lung, oral and heart. In this study, we investigated the effects of e-liquids on otitis media (OM) using human middle ear epithelial cells (HMEECs). Menthol-flavored e-liquid induced si

Emergency Medical ServicesHealth Professions
6
Article|24 citations·2020
Comparison of newborn hearing screening results between well babies and neonates admitted to the neonatal intensive care unit for more than 5 days: Analysis based on the national database in Korea for 9 years
Jiwon Chang, Seung Ha Oh, Su-Kyoung Park
SJR Q1PLoS ONEOA

The prevalence of hearing loss in infants who were hospitalized in NICU for more than 5 days was about seven times higher than that in healthy newborns. However, different referral rates were noted depending on both institutions and the screening methods. These differences need to be addressed in order to improve our program and ensure that all neonates with hearing loss, especially neonates with high risk factor, are detected and appropriately referred for the treatment.

Sensory SystemsNeuroscience
7
Article|23 citations·2016
Sodium Selenite Acts as an Otoprotectant against Neomycin-Induced Hair Cell Damage in a Zebrafish Model
Jiwon Chang, June Choi, Yoon Chan Rah, Myung Hoon Yoo, Kyoung Ho Oh, Gi Jung Im, Seung Hun Lee, Soon Young Kwon, Hae‐Chul Park, Sung Won Chae, Hak Hyun Jung
SJR Q1PLoS ONEOA

Sodium selenite is a trace element essential for many physiological functions in the body. It is involved in various biological processes; it acts as a cofactor for antioxidant enzymes that protect against free radicals and is reported to limit metal-mediated oxidative DNA damage. In the present study, we investigated the effect of sodium selenite on neomycin ototoxicity in wild-type and transgenic zebrafish (Brn3C: EGFP). Five or six days post-fertilization, zebrafish larvae were co-exposed to

Nutrition and DieteticsNursing
8
Article|23 citations·2013
Protective Role of Trimetazidine Against Neomycin-induced Hair Cell Damage in Zebrafish
Jiwon Chang, Gi Jung Im, Sung Won Chae, Seung Hoon Lee, Soon‐Young Kwon, Hak Hyun Jung, Ah-Young Chung, Hae‐Chul Park, June Choi
SJR Q1Clinical and Experimental OtorhinolaryngologyOA

OBJECTIVES: Trimetazidine (TMZ) is known to reduce the generation of oxygen-derived free radicals. The objective of the present study was to evaluate the effects of TMZ on neomycin-induced ototoxicity in transgenic zebrafish (Brn3C: EGFP). METHODS: Five-day, postfertilization zebrafish larvae were exposed to 125 µM neomycin and one of the following TMZ concentrations for 1 hour: 10 µM, 100 µM, 500 µM, 1,000 µM, 1,500 µM, or 2,000 µM. Hair cells within the neuromasts of the supraorbital (SO1 and

Sensory SystemsNeuroscience
9
Article|22 citations·2015
Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line
Gi Jung Im, Jiwon Chang, Sehee Lee, June Choi, Hak Hyun Jung, Hyung‐Min Lee, Sung Hoon Ryu, Su Kyoung Park, Jin Hwan Kim, Hyung‐Jong Kim
SJR Q2Hearing Research
SpectroscopyChemistry
10
Article|18 citations·2011
Nasopharynx as a Microbiologic Reservoir in Chronic Suppurative Otitis Media: Preliminary Study
Jiwon Chang, Sung-Ho Lee, June Choi, Gi Jung Im, Hak Hyun Jung
SJR Q1Clinical and Experimental OtorhinolaryngologyOA

OBJECTIVES: The present study was designed to identify the correlations of bacterial strains of the middle ear and the nasopharynx in chronic suppurative otitis media (CSOM) patients who were scheduled for operations. METHODS: Sixty-three patients with CSOM were enrolled in the study. Culture specimens were collected from the middle ear and nasopharynx of patients who were admitted for operation. Samples collections were performed 3 times; from the middle ear and nasophaynx at the admission day,

OtorhinolaryngologyMedicine
11
Article|13 citations·2016
Asian Sand Dust Enhances the Inflammatory Response and Mucin Gene Expression in the Middle Ear
Jiwon Chang, Yoon Young Go, Moo Kyun Park, Sung Won Chae, Seon Heui Lee, Jae‐Jun Song
SJR Q1Clinical and Experimental OtorhinolaryngologyOA

Environmental ASD exposure can result in the development of otitis media.

SurgeryMedicine
12
Article|12 citations·2011
Dilute vinegar therapy for the management of spontaneous external auditory canal cholesteatoma
Jiwon Chang, June Choi, Gi Jung Im, Hak Hyun Jung
SJR Q1European Archives of Oto-Rhino-Laryngology
OtorhinolaryngologyMedicine
13
Article|12 citations·2011
Calcium imaging in gentamicin ototoxicity: Increased intracellular calcium relates to oxidative stress and late apoptosis
Jiwon Chang, Ji Yun Yang, June Choi, Hak Hyun Jung, Gi Jung Im
SJR Q2International Journal of Pediatric Otorhinolaryngology
Sensory SystemsNeuroscience
14
Article|9 citations·2022
Acute Alcohol Intake Impairs the Velocity Storage Mechanism and Affects Both High-Frequency Vestibular-Ocular Reflex and Postural Control
Hyo Geun Choi, Sung Kwang Hong, Su Kyoung Park, Hyo‐Jeong Lee, Jiwon Chang
SJR Q2International Journal of Environmental Research and Public HealthOA

BACKGROUND: Acute alcohol intake is known to cause gait instability, dizziness, and lack of psychomotor coordination. Previous studies demonstrated the positive effects of alcohol on the oculomotor system and the low-frequency vestibulo-ocular reflex (VOR). However, the low-frequency VORs is a rather un-physiologic stimulation, and the reported explanations regarding the relations between the alcohol-induced VOR changes and posture control are inconsistent. OBJECTIVE: The present study evaluates

NeurologyNeuroscience
15
Article|8 citations·2017
High Incidence of Bell's Palsy After Mastoidectomy: A Longitudinal Follow-up Study
Hyo Geun Choi, Songyong Sim, Sung Kwang Hong, Su-kyoung Park, Hyo‐Jeong Lee, Jiwon Chang
SJR Q1Otology & Neurotology

OBJECTIVE: The objective of this study was to compare the prevalence of Bell's palsy in participants who underwent mastoidectomy (to treat chronic otitis media) and nonmastoidectomy participants (control). METHODS: Using the national cohort study from the Korean Health Insurance Review and Assessment Service, mastoidectomy patients (2,045) and control participants (8,180) were matched 1:4 for age, sex, income, and region of residence. The prevalence of Bell's palsy in both the groups was measure

NeurologyMedicine

Research Areas

Sensory SystemsNeurologySurgeryMolecular BiologyOtorhinolaryngologyPhysiology

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