Ji Won Park
Seoul National University · 医学
研究室紹介
Professor Ji Won Park's research lab specializes in translational biomedical research with a focus on cancer biology, nanomedicine, and molecular mechanisms of inflammation and vascular regulation. The lab investigates innovative therapeutic strategies using nanomaterials—such as magnetite-PEI nanoclusters and silver nanoparticles—for targeted gene delivery and modulation of inflammatory pathways in diseases like colorectal cancer and asthma. A key research direction involves understanding the role of bioactive molecules, including nitric oxide and cytokines, in regulating thrombosis, immune responses, and tumor progression. The lab also explores prognostic biomarkers, such as PIVKA-II in hepatocellular carcinoma, to improve clinical outcomes through precision medicine approaches.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Robot-assisted surgery in rectal cancer showed TME quality comparable with that of laparoscopic surgery, and it demonstrated similar postoperative morbidity, bowel function recovery, and quality of life.
Magnetofection has been utilized as a powerful tool to enhance gene transfection efficiency via magnetic field-enforced cellular transport processes. The accelerated accumulation of nucleic acid molecules by applying an external magnetic force enables the rapid and improved transduction efficiency. In this study, we developed magnetite nanocrystal clusters (PMNCs) cross-linked with polyethylenimine (PEI) to magnetically trigger intracellular delivery of small interfering RNA (siRNA). PMNCs were
Nitric oxide (NO) appears to play an important role in the regulation of thrombosis and hemostasis by inhibiting platelet function. The discovery of NO generation by reduction of nitrite (NO₂⁻) and nitrate (NO₃⁻) in mammals has led to increased attention to these anions with respect to potential beneficial effects in cardiovascular diseases. We have previously shown that nitrite anions at 0.1 µM inhibit aggregation and activation of human platelet preparations in vitro in the presence of red blo
BACKGROUND: Immunomodulatory cytokines and systemic inflammatory markers are important during cancer development and progression. This study investigated the association and prognostic impact of systemic cytokine profiles and inflammatory markers in colorectal cancer (CRC). METHODS: Interleukin (IL)-1β, IL-6, IL-8, IL-9, IL-10, tumour necrosis factor (TNF)-α and vascular endothelial growth factor (VEGF) serum levels were measured using multiplex bead assays in CRC patients. Data on systemic infl
The anti-inflammatory action of silver nanoparticles (NPs) has been reported in a murine model of asthma in a previous study. But more specific mechanisms of silver NPs in an attenuation of allergic airway inflammation have not yet been established. Vascular and mucous changes are believed to contribute largely in pathophysiology in asthma. Among various factors related to vascular changes, vascular endothelial growth factor (VEGF) plays a pivotal role in vascular changes in asthma. Mucin protei
Serum PIVKA-II level, not serum AFP, was a valuable independent prognostic factor in HBV-related HCC.
Abstract Throughout an individual’s lifetime, genomic alterations accumulate in somatic cells 1–11 . However, the mutational landscape induced by retrotransposition of long interspersed nuclear element-1 (L1), a widespread mobile element in the human genome 12–14 , is poorly understood in normal cells. Here we explored the whole-genome sequences of 899 single-cell clones established from three different cell types collected from 28 individuals. We identified 1,708 somatic L1 retrotransposition e