Ji Young Oh
Yonsei University · 医学
研究室紹介
Professor Ji Young Oh's research lab focuses on translational and molecular medicine, with a strong emphasis on neurological and renal disorders, genetic causes of kidney disease, and the pathophysiology of electrolyte imbalances. The lab investigates gene therapy strategies for neurodevelopmental disorders such as Rett syndrome and MECP2 duplication syndrome, utilizing advanced viral vector systems and regulatory elements to achieve precise gene expression. Additionally, the lab explores the impact of nutritional supplements on physiological function and stamina, and examines cultural narratives in Korean drama to understand the construction of collective memory and emotional regulation in contemporary society.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Hyponatremia (sodium levels of <135 mEq/L) is one of the most common electrolyte imbalances in clinical practice, especially in patients with neurologic diseases. Hyponatremia can cause cerebral edema and brain herniation; therefore, prompt diagnosis and proper treatment is important in preventing morbidity and mortality. Among various causes of hyponatremia, diagnosing syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral/renal salt wasting syndrome (C/RSW) is difficult
The effects of a silk amino acid (SAA) preparation on the physical stamina and male reproductive function of mice were investigated. Eight-week-old male ICR mice (29-31 g) were orally administered SAA (50, 160 or 500 mg/kg) for 44 d during 30-min daily swimming exercise. The mice were subjected to a weight-loaded (5% of body weight) forced swimming on the 14th, 28th and 42nd day to determine maximum swimming time, and after a 2-d recovery period (treated with SAA without swimming exercise), para
Inactivating mutations and the duplication of methyl-CpG binding protein 2 (MeCP2), respectively, mediate Rett syndrome (RTT) and MECP2 duplication syndrome. These disorders underscore the conceptual dose-dependent risk posed by MECP2 gene therapy for mosaic RTT patients. Recently, a miRNA-Responsive Autoregulatory Element (miRARE) mitigated the dose-dependent toxicity posed by self-complementary adeno-associated viral vector serotype 9 (AAV9) miniMECP2 gene therapy (scAAV9/miniMECP2-myc) in mic
본 연구는 <응답하라 1997>(tvN)이라는 드라마 텍스트 분석을 통해 현재의 정서구조 아래에서 90년대의 집합기억이 어떻게 생산되는지 알아보고자 하는 시도이다. <응답하라 1997>은 2030세대뿐만 아니라 모든 세대의 공감을 얻을 수 있는 과거 회상의 방식으로 노스탤지어를 사용하였고, 특히 10대 소녀들의 팬덤 문화를 통해 90년대의 대중문화 소비의 화려한 집합기억을 전면에 등장시켰다. 본 연구는 계열체적, 통합체적, 컨텍스트적 분석을 통해 <응답하라 1997>이 재현하는 ‘과거’의 90년대가 ‘현재’의 사회적 맥락 안에서 구성된 의미를 지니고 있음을 파악하였다. 즉 <응답하라 1997>은 90년대가 가진 불안이나 상처, 어두운 기억을 90년대의 화려한 소비문화로 대체시키면서 과거를 낭만화하여 소비하기 적당한 매끄러운 서사로 만들어내고 있다. 그러나 이 모든 위로와 치유는 문화 소비 안에서의 주체적 경험이라는 것과 대중문화 텍스트의 자기 텍스트화의 과정 안에서 이루어진 것이다.
Our results indicate that noninfectious complications of PD are common, though they hardly lead to catheter removal or HD in pediatric patients on PD.
Understanding the genetic causes of kidney disease is essential for accurate diagnosis and could lead to improved therapeutic strategies and prognosis. To accurately and promptly identify the genetic background of kidney diseases, we applied a targeted next-generation sequencing gene panel including 203 genes associated with kidney disease, as well as diseases originating in other organs with mimicking symptoms of kidney disease, to analyze 51 patients with nonspecific nephrogenic symptoms, foll
Neutrophil apoptosis is a constitutive process that can be enhanced or delayed by signals triggered by various stimuli. In this work, we investigated the action mechanism of phospholipase D (PLD) and its expression in the inhibition of spontaneous and Fas-mediated apoptosis. Anti-Fas antibody-stimulated apoptosis of neutrophils was significantly blocked by the exogenous addition of bacterial PLD from Streptomyces chromofuscus (scPLD), and neutrophils cultured for 24 h in the presence of anti-Fas
Inborn errors of immunity (IEI) include a variety of heterogeneous genetic disorders in which defects in the immune system lead to an increased susceptibility to infections and other complications. Accurate, prompt diagnosis of IEI is crucial for treatment plan and prognostication. In this study, clinical utility of clinical exome sequencing (CES) for diagnosis of IEI was evaluated. For 37 Korean patients with suspected symptoms, signs, or laboratory abnormalities associated with IEI, CES that c
VOCs removal under humid conditions is an important issue in the various industries. However,adsorption capacity of commercial coconut-shell–based activated carbon (CAC) is diminishedconsiderably in high relative humidity. In this study, we prepared resin-based activated carbon (RAC)from strong cation-exchange resins consisting of polystyrene with divinylbenzene, and investigatedbenzene adsorption characteristics under humid conditions. The results of water isotherm andbreakthrough experiments r
저출산 고령화로 헌혈인구는 감소하고, 노년층의 혈액사용량은 증가할 것으로 예상되어 혈액부족과 수혈의 안정성 문제가 대두되고 있다. 이에 본 연구에서는 만성 퇴행성관절염인 슬관절과 고관절 전치환술 환자의 수혈에 영향을 주는 요인을 분석하고자 하였다. 이를 위해 건강보험심사평가원의 2011년 환자표본자료 중 입원환자 5,370명을 대상으로 하였으며, SPSS 20 프로그램을 이용하여 로지스틱 회귀분석을 실시하였다. 독립변수로 사용된 변수는 병원특성과 환자특성으로 병원특성은 의료기관 종류, 설립구분, 기관소재지와 가동병상수를, 환자특성으로는 성, 연령, 중증도, 전신마취유무, 주 진단, 빈혈유무와 의료보험종류로 구분하였다. 분석결과, 슬관절전치환술 환자의 수혈에 유의한 영향을 미치는 변수로는 의료기관 종류, 기관소재지, 성, 연령, 중증도, 주 진단, 빈혈유무였으며, 고관절전치환술 환자의 수혈에 유의한 영향을 주는 변수로는 의료기관 종류, 기관소재지, 성, 연령, 중증도, 전신마취유무,
Through this study, we were able to confirm the value of WES as one of the diagnostic tools for PCD, which increases with TEM, rather than single gene tests. These results will prove useful to hospitals with limited access to PCD diagnostic testing but with relatively efficient in-house or outsourced access to genetic testing at a pre-symptomatic or early disease stage.
In old age, measures to cope with the natural phenomenon of aging and various diseases of the elderly due to the deterioration of physical function are also a challenge for this society. While interest in systematic health is increasing, it is true that awareness and interest in oral-related diseases is relatively lacking. This study aims to present basic data necessary to improve the quality of life for senior citizens aged 65 or older by improving the oral dryness caused by systemic health. By
Purpose: The aim of this study was to verify renal inflammation following Kawasaki disease (KD) using single photon emission computed tomography along with Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA renal SPECT).\n\nMethods: From March 2011 to October 2011, 15 patients diagnosed with KD at the National Health Insurance System Ilsan Hospital were enrolled in the study. All patients underwent DMSA renal SPECT to evaluate renal involvement during the acute phase of KD. Urine 棺2-micro
Purpose: The aim of this study was to verify renal inflammation following Kawasaki disease (KD) using single photon emission computed tomography along with Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA renal SPECT). Methods: From March 2011 to October 2011, 15 patients diagnosed with KD at the National Health Insurance System Ilsan Hospital were enrolled in the study. All patients underwent DMSA renal SPECT to evaluate renal involvement during the acute phase of KD. Urine β2-microglo