Jihye Lee
Yonsei University · 医学
研究室紹介
Professor Jihye Lee's research lab focuses on molecular mechanisms underlying inflammatory and immune responses in transplantation rejection, neurodegenerative pain conditions, and antiviral defense. The lab investigates key signaling pathways such as the IL-6 amplifier in NF-κB/STAT3 activation, exploring their roles in chronic allograft rejection and autoimmune pathology. Additionally, the lab examines neuroprotective mechanisms of serotonin receptor modulation in chemotherapy-induced neuropathy and evaluates natural compounds—particularly bioactive fractions from black raspberry seeds—for antiviral activity. A recurring theme is the translation of molecular insights into clinical applications for inflammatory diseases and peripheral neuropathy.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15PURPOSE: The purpose of this study was to evaluate the predictive value of ultrasonography (US) patterns based on the 2015 American Thyroid Association (ATA) guidelines for malignancy in atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) nodules. METHODS: From January 2014 to August 2015, 133 thyroid nodules that were initially diagnosed as AUS/FLUS on fine needle aspiration (FNA) were included in this study. Each nodule was assigned a category with
Pancreatic cancer (PC) is known to be frequently associated with venous thromboembolism (VTE). Although treatment and prophylaxis strategies for VTE in PC patients were updated recently, these were mainly based on data from Western populations and were not verified in East Asian ethnic populations.We investigated the clinical characteristics of VTE in East Asian PC patients. We reviewed electronic medical records (EMR) of 1334 patients diagnosed with pancreatic adenocarcinoma from 2005 to 2010 a
Allergic reactions to mammalian meats are very rare among the adult food allergies. Food allergies usually show rapid onset of symptoms within 1–2 h after ingestion of causative foods. Recently, some patients with episodes of anaphylaxis several hours after eating mammalian meat have been reported.1, 2 Most of these patients showed delayed reactions, usually 3–7 h after ingestion of mammalian meats, however, they had no history of allergic reaction to mammalian meats before these events. Commins
본 연구는 학교 밖 청소년의 사회적 낙인감과 이후 초기 성인기의 우울증상 예방을 궁극적 목표로, 학교 밖 청소년이 지각한 부모지지와 또래지지, 사회적 낙인감이 이후 초기 성인기의 우울증상에 미치는 영향과 더불어 사회적 낙인감의 매개효과를 검증하였다. 본 연구는 한국청소년정책연구원의 학업중단청소년패널 1차~5차년도 조사에 참여한 776명(남아 444명)의 청소년을 분석 대상에 포함하였으며, 자료를 분석하기 위해 기술통계분석을 실시한 후 경로모형을 적용하였다. 연구결과, 첫째, 학업중단 초기 부모지지와 또래지지는 학업중단 2년 후 경험하는 사회적 낙인감에 직접적으로 부적인 영향을 미쳤으며, 이는 성인 초기 우울증상에 직접적으로 정적인 영향을 미쳤다. 둘째, 학업중단 초기 부모지지와 또래지지는 성인 초기 우울증상에 직접적인 영향을 미치지는 않았으나 학업중단 2년 후 경험한 사회적 낙인감을 매개로 하여 성인 초기 우울증상에 간접적인 영향을 미치는 것으로 나타났다. 본 연구의 결과는 학업중단
BACKGROUND: For patients with papillary thyroid carcinoma (PTC), lymph node metastasis is associated with an increased recurrence rate. The purpose of this study was to investigate whether the vascular endothelial growth factor (VEGF), microvessel density (MVD), and vascular index (VI) can predict lymph node metastasis in patients with PTC. METHODS: From January 2011 to October 2011, 202 patients with PTCs underwent preoperative staging ultrasound evaluation. To evaluate vascularity, we measured
PURPOSE: To evaluate the clinical and sonographic (US) features of metastatic tumors from extramammary malignancies to the breast. METHODS: This study included 23 patients with pathologically proven metastases in the breast. Two radiologists retrospectively analyzed the images from US (n = 23), mammography (n = 11), and MRI (n = 5) examinations according to BIRADS. RESULTS: Patients presented with a palpable mass or diffuse breast swelling (21/23) or were asymptomatic (2/23). Eighteen patients h
Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
occurred in our case. Atypical presentations of tinea faciei can lead to misdiagnosis. The present case underlines that physicians should keep in mind that clinical features of superficial fungal infection can be substantially modified by incorrect treatment, to mimic even herpes simplex virus infection. Fungal infection should be on the list of differential diagnoses of facial eruptions, especially in cases not responding to preceding management.
BACKGROUND: The purpose of this study was to validate the modified 4-tiered categorization system and to compare stratification of malignancy risk in small thyroid nodules with the 2015 American Thyroid Association (ATA) management guidelines. METHODS: From January 2015 to December 2015, 737 thyroid nodules measured ≥ 1 cm and <2 cm were included in this study. Each nodule was assigned a category with the ultrasonographic patterns described by the 2015 ATA guidelines. RESULTS: On univariate anal
Combined treatment with surgical subcision and intralesional corticosteroid injection is a cost-effective and minimally invasive treatment for postoperative adhesive thyroidectomy scars.
본 연구에서는 의견이나 감정을 담고 있는 의견 문서들의 자동 분류 성능을 향상시키기 위하여 개념색인의 하나인 잠재의미색인 기법을 사용한 분류 실험을 수행하였다. 실험을 위해 수집한 1,000개의 의견 문서는 500개씩의 긍정 문서와 부정 문서를 포함한다. 의견 문서 텍스트의 형태소 분석을 통해 명사 형태의 내용어 집합과 용언, 부사, 어기로 구성되는 의견어 집합을 생성하였다. 각기 다른 자질 집합들을 대상으로 의견 문서를 분류한 결과 용어색인에서는 의견어 집합, 잠재의미색인에서는 내용어와 의견어를 통합한 집합, 지도적 잠재의미색인에서는 내용어 집합이 가장 좋은 성능을 보였다. 전체적으로 의견 문서의 자동 분류에서 용어색인 보다는 잠재의미색인 기법의 분류 성능이 더 좋았으며, 특히 지도적 잠재의미색인 기법을 사용할 경우 최고의 분류 성능을 보였다.