Jiyoung Choi
Yonsei University · 生化学・遺伝学・分子生物学
研究室紹介
Professor Jiyoung Choi's research lab focuses on translational biomedical research, particularly in the areas of rare genetic skin disorders, pediatric trauma, and microbial pathogenesis. The lab investigates the molecular mechanisms underlying conditions such as Olmsted syndrome and Hutchinson-Gilford progeria syndrome, with an emphasis on signaling pathways like WNT/β-catenin and ion channels such as TRPV3. Additionally, the lab explores psychosocial interventions for trauma-exposed children and develops non-invasive dermatological treatments using laser technologies.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Two Gram-stain-negative, non-fermentative bacterial strains, designated 11-0202(T) and 11-0607, were isolated from soil in South Korea, and four others, LUH 13522, LUH 8638, LUH 10268 and LUH 10288, were isolated from a beet field in Germany, soil in the Netherlands, and sediment of integrated fish farms in Malaysia and Thailand, respectively. Based on 16S rRNA, rpoB and gyrB gene sequences, they are considered to represent a novel species of the genus Acinetobacter. Their 16S rRNA gene sequence
Patients with Hutchinson-Gilford progeria syndrome (HGPS) have low bone mass and an atypical skeletal geometry that manifests in a high risk of fractures. Using both in vitro and in vivo models of HGPS, we demonstrate that defects in the canonical WNT/β-catenin pathway, seemingly at the level of the efficiency of nuclear import of β-catenin, impair osteoblast differentiation and that restoring β-catenin activity rescues osteoblast differentiation and significantly improves bone mass. Specificall
Combined treatment with Er:YAG laser and long-pulsed alexandrite laser is effective for the removal of small benign melanocytic nevi with minimal adverse effects and low recurrence rates.
Phytophotodermatitis is a condition that occurs by contact with plants containing phototoxic agents such as furocoumarins and psoralens with subsequent ultraviolet exposure. Phytophotodermatitis typically presents as sharply defined erythematous patches with occasional blistering, sometimes accompanied with pain or itching sensation. In some cases, however, sudden appearance of asymptomatic hyperpigmentation can be the only clinical finding of phytophotodermatitis. Here, we present two patients
Olmsted syndrome (OS) is a rare congenital skin disorder characterized by severe palmoplantar and periorificial keratoderma, alopecia, onychodystrophy, and severe pruritus. Recently, pathogenic 'gain-of-function' mutations of the transient receptor potential vanilloid 3 gene (TRPV3), which encodes a cation channel involved in keratinocyte differentiation and proliferation, hair growth, inflammation, pain and pruritus, have been identified to cause OS. Due to the rarity, the pattern of inheritanc
본 연구는 성학대 피해 아동을 대상으로 외상초점 인지행동치료의 효과성을 확인하고, 각 증상의 호전에 영향을 미치는 요인들을 탐색하고자 하였다. 외상초점 인지행동치료는 노출, 인지․정서적 처리, 건강한 성과 자기보호기술에 대한 심리교육 등의 요소로 구성되었다. 연구대상은 성학대 피해로 아동성폭력 전담센터인 서울해바라기 아동센터를 방문하여 정신과 진료와 심리평가를 거쳐 후유증이 심각하다고 판단되어 치료에 의뢰된 만 8세에서 13세의 여자 아동 27명이었다. 그 결과 아동이 보고한 외상후증상, 해리증상, 성관련 문제와 부모가 보고한 내・외현화 행동문제에서 모두 유의한 호전을 보였다. 한편, 아동의 성학대 피해정도, 성학대 이전의 복합외상, PTSD진단, 가족형태, 그리고 치료 회기수 중에서 증상 호전에 가장 유의한 영향을 주는 요인은 PTSD진단이었으며 복합외상 여부, 가족형태, 회기수도 몇몇 증상 호전에 영향을 주었다. 본 연구의 시사점과 제한점을 논의하였다.
이 연구는 협응 변인들을 동원하여 태권도 돌려차기기술을 지배하는 기본적인 제어기전의 이해를 토대로 돌려차기기의 동작형태를 분류하고, 차기동작의 단계별 학습순서를 제시하는 데 목적을 두었다. 한국 올림픽 국가대표로 선발된 6명의 남자 선수들을 연구대상자로 돌려차기 기술 동안 3차원 영상분석법을 이용하여 개개 관절과 분절들의 각도를 계산하였다. 이용된 협응 변인으로는 각도 대 각도 도면과 각도 대 각속도 도면이었다. 돌려차기 동안 몸통의 단축성 수축에 의해 시작된 스프링과 같은 제어기전은 하부몸통과 엉덩관절의 공간적 협응에 의해 하지관절의 탄도적 제어기전으로 전이되는 과정을 관찰할 수 있었다. 이렇듯 협응 변인을 이용한 총체적인 돌려차기의 연구는 단편적으로 차는 다리만의 운동학적 변인들에 기초하여 돌려차기를 스피드 총합의 원리 혹은 분절순서이론에 기초한 던지는 듯한 동작유형과 유사한 후려차기 유형으로 분류한 결과보다 돌려차기의 기본적인 제어기전을 깊이 이해하는데 매우 유용한 연구방향인
Biomechanical Analysis of Standing Long Jump-Elementary School's Children-
Recently among several tennis techniques forehand stroke has been greatly changed in the aspect of spin, grip and stance. The most fundamental factor among the three factors is the stance which consists of open, square and close stance and it is very important to know the patterns of plantar pressure distribution for the better understanding of forehand stroke. Therefore, the purpose of this study was to investigate the change of plantar pressure distribution in open stance during forehand strok
Phytophotodermatitis is a condition that occurs by contact with plants containing phototoxic agents such as furocoumarins and psoralens with subsequent ultraviolet exposure. Phytophotodermatitis typically presents as sharply defined erythematous patches with occasional blistering, sometimes accompanied with pain or itching sensation. In some cases, however, sudden appearance of asymptomatic hyperpigmentation can be the only clinical finding of phytophotodermatitis. Here, we present two patients
The purpose of this study was to assess the influence of scapular alignment on the electromyographic (EMG) activity of the trapezius in people with a short pectoralis minor muscle. For the study, we recruited 15 volunteers who had positive results for short on a pectoralis minor muscle length test. We measured the EMG activity of the upper, middle and lower trapezius muscles. The participants lifted their dominant arm to ear level with the thumb up toward the ceiling in the prone position on a t