Jong Ho Lee
Seoul National University · 医学
研究室紹介
Professor Jong Ho Lee's research lab specializes in biomedical engineering and regenerative medicine, with a focus on developing advanced biomaterials and drug delivery systems for clinical applications. Key research directions include the design of functional hydrogel-nanoparticle complexes for controlled release of growth factors like rhBMP-2 in bone regeneration, and investigating implant-biofilm interactions to prevent complications such as capsular contracture in breast implants. The lab also explores the interplay between inflammation, bacterial biofilms, and implant materials, as well as the impact of early-life environmental factors on neurobehavioral outcomes. Additionally, the lab contributes to surgical innovation, particularly in combined oncoplastic breast reconstruction and prophylactic antibiotic strategies in oral surgery.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15BACKGROUND/AIM: The mechanisms underlying capsular contracture remain unclear. Emerging evidence supports the inflammation hypothesis, according to which bacteria from an adherent biofilm cause chronic inflammation and collagen deposition on the implant and trigger capsular contracture. Our goal was to evaluate the effect of different types of breast implants on the growth of Staphylococcus aureus, S. epidermidis, and Pseudomonas aeruginosa, which are commonly found in biofilms in infection. MAT
Background. A combination of the reduction mammoplasty technique and breast reconstruction allows surgeons to lift ptotic breasts through local flaps and skin reduction during surgery for breast cancer. This study presents a reliable course for the combination of partial and skin or nipple-sparing mastectomy with reduction-reconstruction surgery. Methods. Fifty-seven patients underwent a partial mastectomy before reduction mammoplasty of both breasts during the same time period between 2014 and
As an efficient controlled release system of rhBMP-2, a functional nanoparticle-130 KDa 5% Hyaluronic Acid (HA) based hydrogel-Nanoparticle(NP) complex was developed and used as a bone transplant. In vivo bone formation was evaluated by soft x-ray, histology, alkaline phosphatase (ALP)/Osteocalcin activity and mineral contents analysis, based on the rat calvarial critical size defect (8 mm in diameter) model. Significantly, effective bone regeneration was achieved with the rhBMP-2 loaded HA base
This study analyzes not only the direct impact of R&D investment on corporate growth for 578 private firms in 2007-2016, but also whether corporate innovation activities play a role as a mediating parameter between R&D investment and corporate growth. For this purpose, we classify companies into IT and non-IT companies and measure the mediating effect by dividing innovation activities into the number of registered patents, applied patents, and sum of them. In addition, this study is based on bot
Background: This study was conducted to examine the effects of ad libitum consumption of highly palatable food (HPF) during adolescence on the adverse behavioral outcome of neonatal maternal separation. Methods: Male Sprague-Dawley pups were separated from dam for 3 hours daily during the first 2 weeks of birth (maternal separation, MS) or left undisturbed (nonhandled, NH). Half of MS pups received free access to chocolate cookies in addition to ad libitum chow from postnatal day 28 (MS+HPF). Pu
논문은 시장과 기술의 급속한 변화에 직면한 한국 대기업의 R&D 공간의 변화 과정과 메커니즘을 학습과 적응의 맥락에서 고찰한 것이다. 사례연구는 한국의 대표적인 전자업체인 LG전자를 대상으로 한 심층적 인터뷰 결과와 문헌조사를 토대로 하였다. 본 연구에서는 대기업 조직의 R&D 공간의 변화는 조직의 공간 형태, 지식과 학습의 공간적 및 조직적 원천, 관계적 근접성에 기초한 학습의 역할 등과도 밀접한 관계를 가지고 있음을 밝힌다. 사례기업의 최근 국내 R&D 공간의 변화는 구상과 실행의 공간적 통합보다는 핵심 연구개발 기능들의 서울중심 집적 강화 경향이 점진적으로 나타나고 있다. 그러나, 본 논문에서는 이러한 R&D 공간의 변화가 학습과 혁신의 선형적 모델로의 회귀를 의미한다고 보기 보다는, 조직적 근접성과 상호작용적 학습 양식을 통해 공간적으로 분산된 조직 역량 및 학습 능력을 유지강화하고자 하는 기업의 전략적 노력과 조직적 프로세스를 반영하고 있다는 점을 강조한다.
※본 연구는 보건복지부 보건의료기술진흥사업의 지원에 의하여 이루어진 것임.(과제고유번호 : 01-PJ5-PG3-20507-003 3)
Objectives: This study was conducted in order to assess the efficacy of 1st generation cephalosporin as use as a single-dose preoperative prophylactic antibiotic for surgical wound infections resulting from intra-oral bone grafting procedures. Materials and Methods: A total of 23 patients who were to undergo intra-oral bone graft procedures participated in this study. After randomization, 2 grams of 1st generation cephalosporin was orally administered to both the experimental and placebo groups
The flap considered at first for the reconstruction large of maxillary defect, especially mid face defect, is scapular free flap, because it provides ample composite tissue which can be designed 3-dimensionally for orbital, facial and oral reconstruction. However, in case of maxillary defect involving hard palate, this flap shows some limitations. First, its bulk prevents oral function and physio-anatomic reconstruction of nasal and oral cavity. Second, mobility and thickness of cutaneous paddle
Three species belonging to genera Acaphylla Keifer and Calacarus Keifer (Prostigmata: Eriophyidae) that cause damage to Camellia (Theaceae) plants, have been newly recorded in Korea. The three species, Acaphylla theae (Watt), Acaphylla theavagrans Kadono, and Calacarus carinatus (Green), have been redescribed and illustrated. Keys to Korean species of the genus Acaphylla; their distribution; and biological information, such as host plants and damage symptoms, are also presented.