Joo-Won Jeong
Yonsei University · 医学
研究室紹介
Professor Joo-Won Jeong's research lab specializes in identifying and characterizing natural compounds with anti-angiogenic, anti-cancer, and neuroprotective properties. The lab focuses on elucidating the molecular mechanisms underlying the therapeutic effects of bioactive phytochemicals such as melatonin, p-coumaric acid, glycyrrhizic acid, cinnamaldehyde, and zingerone in cancer and neurodegenerative diseases. Key research directions include tumor angiogenesis inhibition, regulation of hypoxia-inducible factor-1α (HIF-1α), modulation of signaling pathways (e.g., AKT, ERK, JNK), and induction of autophagy in neurodegenerative models. The lab integrates in vitro cell culture studies with in vivo animal models to validate the translational potential of natural compounds in disease therapy.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Endoscopic findings and instability of vital signs were associated with the disease course of ischemic colitis. A novel scoring model based on presence of tachycardia, shock within 24 hours after admission, and endoscopic evidence of ulceration provides a method of assessing patient prognosis and should be further validated.
Most lesions with low or indeterminate risk did not changed in size during follow-up period, but one fifth of high-risk lesions were identified as borderline or malignant after surgery. Surgical resection should be performed in patients with high-risk cysts considering their clinical condition, and radiological follow-up of nonsurgically managed cysts should be continued for more than 6 years.
Endoscopic papillary balloon dilation (EPBD) is an alternative method of endoscopic sphincterotomy (EST). Although concerns regarding post-procedure pancreatitis have been expressed, EPBD has come to be recognized as an effective and safe method for stone removal in specific cases. To analyze the proper indications, ideal methods, complications, and long-term follow-up results for EPBD, we reviewed articles about EPBD located through a search of the PubMed data base. We analyzed the ballooning m
Risk prediction requires comprehensive integration of clinical information and concurrent radiological findings. We present an upgraded chest radiograph (CXR) explainable artificial intelligence (xAI) model, which was trained on 241,723 well-annotated CXRs obtained prior to the onset of the COVID-19 pandemic. Mean area under the receiver operating characteristic curve (AUROC) for detection of 20 radiographic features was 0.955 (95% CI 0.938-0.955) on PA view and 0.909 (95% CI 0.890-0.925) on AP
We found that acute pancreatitis after cardiac valve surgery requires longer hospitalization and increases the in-hospital mortality rate. Clinicians should be aware that patients could develop pancreatitis after cardiac valve surgery, especially in patients with hypertension and chronic kidney disease treated with norepinephrine.
BACKGROUND/AIMS: This phase II study assessed the efficacy and safety of FOLFOX4 as a rescue therapy in patients with gemcitabine-refractory pancreatic cancer. METHODOLOGY: The study included patients with advanced pancreatic cancer who had failed gemcitabine-based chemotherapy. FOLFOX4 was administered biweekly as follows: oxaliplatin, 85 mg/m² as a 2-hour infusion (day 1); leucovorin, 200 mg/m²/day as a 2-hour infusion (days 1 and 2); 5-fluorouracil, bolus 400 mg/m²/day and 600 mg/m²/day as a
The risk of a second primary PC was higher in patients with CRC. Further studies are needed to identify the risk factors and generate a screening strategy for cancer survivors.
The first step in reading a capsule endoscopy (CE) is determining the gastrointestinal (GI) organ. Because CE produces too many inappropriate and repetitive images, automatic organ classification cannot be directly applied to CE videos. In this study, we developed a deep learning algorithm to classify GI organs (the esophagus, stomach, small bowel, and colon) using a no-code platform, applied it to CE videos, and proposed a novel method to visualize the transitional area of each GI organ. We use
본 연구에서는 만 4세 유아의 마음이론과 도덕적 판단의 발달 수준에 대해 살펴보고 마음이론과 도덕적 판단의 관계에 대해 알아보고자 하였다. 이를 위해 만 4세 유아 117명을 대상으로 내용교체 과제와 위치이동 과제를 실시하였고, 과실, 거짓말, 훔치기 항목에 대한 도덕적 판단을 근거로 한 의도성 판단 지수를 사용하여 유아의 도덕적 판단 능력을 측정하였다. 본 연구의 결과를 요약하면 다음과 같다. 첫째, 과반수의 만 4세 유아들이 마음이론 두 과제의 개념을 이해하는 것으로 나타났다. 만 4세 유아는 자신의 틀린 믿음에 대한 표상을 타인의 틀린 믿음에 대한 표상보다 잘 하는 것으로 나타났으며, 타인의 틀린 믿음에 대한 표상을 타인의 후속행동에 대한 예측보다 잘 하는 것으로 나타났다. 둘째, 만 4세 유아들은 도덕적 판단을 할 때 의도와 결과를 같은 비중으로 중요하게 고려하는 것으로 나타났다. 셋째, 유아의 마음이론과 도덕적 판단은 정적 상관이 있었다. 즉, 틀린 믿음 표상능력이 높을수록
GI cancer patients tended to have a first relative with a history of concordant GI cancer. Personal factors (old age and male) and lifestyle (smoking) contribute to the development of GI cancer, independently. Individuals with high risk for GI cancers may be advised to undergo screening at an earlier age.
Background/Aims: We aimed to investigate the incidence of second primary pancreatic cancer (PC) after colorectal cancer (CRC) and to identify risk factors associated with subsequent PC. Methods: The observed incidence of a subsequent PC in patients with CRC was standardized using a population with CRC from the Korean Central Cancer Registry (KCCR). The expected incidence rate of PC was obtained by assuming that the select group experienced the same cancer incidence as the corresponding general p
Behcets disease is a multisystemic inflammatory disease characterized with recurrent oral ulcer, genital ulcer, and multiple organ involvement. Aplastic anemia is one of the rarest complications of Behcets disease. There were only several reports about Behcets disease associated myelodysplatic syndrome worldwide. Moreover, aplastic anemia in intestinal Behcets disease was rarely reported. Here, we present a case of aplastic anemia with trisomy 8 and trisomy 9 in intestinal Behcets disease and a
Abstract Clinical risk prediction requires comprehensive integration of clinical information and concurrent radiological findings. We present an upgraded chest radiograph (CXR) explainable artificial intelligence (xAI) model, which was trained on 241,723 well-annotated CXRs obtained prior to the onset of the COVID-19 pandemic. Mean area under the receiver operating characteristic curve (AUROC) for detection of 20 radiographic features was 0.955 (95% CI 0.938-0.955) on PA view and 0.909 (95% CI 0
Brunner's gland hyperplasia is a rare tumor of the duodenum and might also be an unusual cause of gastrointestinal bleeding. In symptomatic patients, treatment requires either surgical resection or endoscopic polypectomy. We report a case of upper gastrointestinal bleeding from a pedunculated Brunner's gland hyperplasia in the duodenal bulb. Endoscopic resection using the detachable snare and hemoclipping was instituted to remove a large pedunculated polyp. The pathologic diagnosis was Brunner's