Jung Jin Lee
Sungkyunkwan University · 医学
研究室紹介
Professor Jung Jin Lee's research lab focuses on translational neuroscience and clinical immunology, with key research directions in anesthetic preconditioning and neuroprotection, particularly the role of isoflurane in modulating ischemic brain injury. The lab also investigates sleep-related breathing disorders, especially in patients with end-stage renal disease and those undergoing surgical interventions like UPPP, linking respiratory physiology with clinical outcomes. Additionally, the lab explores mucosal vaccine delivery systems using Salmonella-based platforms, with a focus on enhancing immune responses through fusion antigens like TetC-Sh28GST. These diverse research areas reflect a strong emphasis on improving patient outcomes through mechanistic insights into anesthesia, sleep disorders, and vaccine immunology.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15BACKGROUND: Preexposure of brain to isoflurane, a commonly used anesthetic, induces ischemic tolerance. This phenomenon is called isoflurane preconditioning. However, it is not known whether isoflurane application after ischemia provides neuroprotection. METHODS: Corticostriatal slices (400 microm) freshly prepared from adult male Sprague-Dawley rats were subjected to a 15-min oxygen-glucose deprivation (OGD; to simulate ischemia in vitro). Isoflurane was applied after OGD. Brain slices were har
This study shows that immediate postoperative complications and oxygen saturation are associated with OSAS severity and the level of obstruction, inducing apnea in those who have undergone UPPP for OSAS.
Lee JJ, Kim GS, Kim JA, Kim S-J, Kang JG, Kim GH, Jung HH. Improvement of sleep-related breathing disorder in patients with end-stage renal disease after kidney transplantation. Clin Transplant 2011: 25: 126–130. © 2009 John Wiley & Sons A/S. Abstract: Sleep-related breathing disorder (SRBD) is a common symptom of end-stage renal disease (ESRD). The aim of this study was to determine whether kidney transplantation improves SRBD. Twenty-four patients with ESRD, who were admitted for kidney transp
Tetanus toxoid has been used widely as an adjuvant. The atoxic fragment C from tetanus toxin (TetC) is potently immunogenic when expressed in Salmonella vaccine strains and has been used as a fusion partner for antigens (Ag). However, there has been no formal comparison of the immunomodulatory impact of TetC on its fusion partners. In this study, we have addressed this important issue. The protective 28-kDa glutathione S-transferase (GST) from Schistosoma haematobium (Sh28GST) was expressed eith
The objective of this study is to investigate the degree of serum sodium changes and its association with patient outcomes in pediatrics undergoing heart surgery with cardiopulmonary bypass (CPB). We reviewed the medical records of 275 pediatric patients who underwent heart surgery with CPB. Prior to CPB, hyponatremia (≤135 mmol/L) was observed in 21 of 275 patients. After initiation of CPB, serum sodium decreased significantly and severe hyponatermia (≤130 mmol/L) subsequently developed in 32 p