Kyung Jun Jeong
Yonsei University · 生化学・遺伝学・分子生物学
研究室紹介
Professor Kyung Jun Jeong's research lab focuses on the genetic and molecular mechanisms underlying pediatric endocrine disorders, particularly Prader-Willi syndrome and growth hormone deficiency. The lab investigates the role of growth hormone therapy in modulating fat distribution and gene expression in adipose tissue, with a special emphasis on GH receptor regulation. Additionally, the lab explores the impact of environmental factors, such as fine particulate matter (PM2.5), on airway inflammation and respiratory health, using non-invasive biomarkers like fractional exhaled nitric oxide (FeNO). The integration of clinical genetics, molecular biology, and environmental health reflects the lab’s translational approach to understanding complex pediatric diseases.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
3Purpose : To detect microdeletion of 15q11-13 region, high resolution cytogenetic analysis or FISH with probe at Prader-Willi syndrome region can be used. We tried to evaluate whether FISH with SNRPN is a more effective method than G-banding microscope in the diagnosis of Prader-Willi syndrome. Methods : Peripheral blood sampling was done on five patients who we suspected of Prader-Willi syndrome clinically and lymphocytes from peripheral blood sampling were cultured. G-banding microscope was us
Exposure to fine particle (PM2.5, particles with an aerodynamic diameter≤2.5 μm) has been demonstrated to be associated with adverse health effects, including local and systemic inflammation in the body, lung function decline and increases in mortality and morbidity of cardiopulmonary diseases. Fractional exhaled nitrogen oxide (FeNO) is a non-invasive surrogate marker of airway inflammation and chronic airway inflammation is a key characteristic in the pathogenesis of asthma. Existing fine part
Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We in- vestigated the changes in fat tissue and GH receptor mRNA in adipose tissue with GH therapy. Methods : Eight children with growth hormone deficiency(GHD) and 9 children with Prader-Willi syndrome(PWS) were studied. The
Research Areas
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