Kyungmin Choi

Deuterium has been recognized as an irreplaceable element in industrial and scientific research. However, hydrogen isotope separation still remains a huge challenge due to the identical physicochemical properties of the isotopes. In this paper, a partially fluorinated metal–organic framework (MOF) with copper, a so-called FMOFCu, was investigated to determine the separation efficiency and capacity of the framework for deuterium extraction from a hydrogen isotope mixture. The unique structure of

The conversion of aryl halides to primary arylamines with a convenient and inexpensive source of ammonia has been a long-standing synthetic challenge. Aqueous ammonia would be the most convenient and least expensive form of ammonia, but such a palladium-catalyzed amination reaction with a high concentration of water faces challenges concerning catalyst stability and competing hydroxylation, and palladium-catalyzed reactions with this practical reagent are rare. Further, most reactions with ammon

Abstract Diaryl difluoromethanes are valuable targets for medicinal chemistry because they are bioisosteres of diaryl ethers and can function as replacements for diaryl methane, ketone, and sulfone groups. However, methods to prepare diaryl difluoromethanes are scarce, especially methods starting from abundant aryl halides. We report the Pd‐catalyzed aryldifluoromethylation of aryl halides with aryldifluoromethyl trimethylsilanes (TMSCF 2 Ar). The reaction occurs when the catalyst contains a sim

Transition metal-mediated catalysis routinely enables substrates of multiple π-systems to be efficiently coupled with various carbon nucleophiles along with simultaneous ring formation. This transformation, however, remains unexplored in connection with pericyclic processes. Reported here is a protocol for cycloalkene synthesis based on the merger of rhodium catalysis and a retro-ene reaction. The approach allows alkyne-tethered hydrazones and organoboronic acids to undergo a cascade of addition

Salmonella enterica serovar Typhimurium is one of the most important bacterial pathogens causing diarrhea.The resistance of S. typhimurium to antimicrobial agents, which has recently been isolated from patients, is causing serious problems.We investigated the effects of salicylic acid (Sal) and acetyl salicylate (AcSal) on the susceptibility of S. typhimurium to cephalosporin antibiotics, which are known to increase resistance to cephalosporin and quinolone antibiotics.The MIC of cephalosporin a

Abstract Metal–organic frameworks (MOFs) are widely used as substrates for creating single‐atom catalysts due to their abundance of ligands, facilitating enzyme‐like activity for biomedical applications. However, the high‐temperature calcination process for single‐atom catalysts limits economical, efficient, and large‐scale synthesis. Here, a simple room‐temperature synthesis of MOF‐based single‐atom and metal cluster catalysts is presented for tumor therapy. Fe/MOF is obtained through a coordin

목 적 : 폐구균은 소아에서 지역사회 획득 폐렴 및 침습성 세균 감염 질환의 가장 흔한 원인 균주이다. 현재까지 90개의 혈청형이 알려져 있는데, 시대와 지역에 따라 혈청형 분포의 차이를 보인다. 현재 7가 폐구균 단백 결합 백신이 사용 중인데, 그 효용성을 정확히 판단하기 위해서는 각 지역의 폐구균 혈청형 분포에 대한 연구가 필수적이다. 재료 및 방법 : 2001년 9월부터 2005년 7월까지 신촌세브란스 병원에 내원하여 배양 검사 상 폐구균 감염이 확진된 308명의 환자로부터 분리된 폐구균의 혈청형 분석과 항생제 감수성 조사를 시행하였다. 결 과 : 폐구균은 객담(62.3%)에서 분리된 경우가 가장 많았고, 혈액(13.0%), 이루(11.0%), 인두(3.9%) 등의 순이었다. 265주에서 혈청형 분석이 가능하였는데, 19F (16.2 %), 19A (12.8%), 23F (8.7%), 6B (7.9%), 6A (7.2%) 및 3(6.0%)의 순으로 나타났다. 15세 이하 소아에

Helicobacter pylori vacuolating toxin (VacA) appears to be unusually stable, not only against extreme pH conditions or high temperatures, but also against common organic solvents or detergents. Under acidic conditions, its activity was markedly increased in the manner of temperature-independent, suggesting a spontaneous activation. A similar finding was also observed under alkaline conditions, however, it should have an appropriate temperature. From these observations, the mechanisms of VacA act

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Primary sinonasal B cell lymphoma is usually presenting with unilateral nasal mass. Mainly its pathologic subtypes by WHO classification are NK/T cell and diffuse large B-cell type in order of frequency. A-65-year-old-male came to emergency room, complaining with loss of visual acuity and ocular pain for one month. PNS CT showed right unilateral nasal mass involving the orbit, skull bass and the sphenoid sinus. We performed the endoscopic sinus surgery, final pathologic diagnosis was diffuse lar

Abstract Mosquito saliva contains a number of immunogenic molecules that can induce allergic reactions in host animals. The oriental tiger mosquito, Aedes togoi (Theobald), feeds on both humans and animals and is also a vector of various pathogenic viruses. However, information on immunogenic antigens in the saliva of this mosquito species is scarce. In this study, we used immunohistochemical staining and confocal microscopy to determine the fine structure of the acini lobes of salivary glands o