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Kyung‐Yeol Lee

Yonsei University · 医学

研究室紹介

Professor Kyung-Yeol Lee's research lab specializes in cerebrovascular diseases, with a focus on acute ischemic stroke mechanisms, imaging biomarkers such as hyperintense vessels on MRI, and hemodynamic alterations in conditions like diabetes mellitus. The lab investigates thrombolytic therapies—including IV and intra-arterial approaches—and evaluates the impact of medications like statins on glucose metabolism. A significant portion of the work also explores environmental and occupational allergens, particularly buckwheat flour-related hypersensitivity in children. The lab integrates clinical imaging, vascular physiology, and allergy diagnostics to improve stroke outcomes and patient management.

acute ischemic strokecerebral hemodynamicsthrombolysisstatin-induced hyperglycemiafood allergy

Research Overview

Papers
436
Total Citations
8,246
Papers (5y)
57
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
57total
2021
2022
2023
2024
2025
Citations per year (5y)
509total
20212022202320242025

Selected Papers

15
1
Article|221 citations·2009
Distal hyperintense vessels on FLAIR
Kyung‐Yul Lee, Lawrence L. Latour, Marie Luby, Amie W. Hsia, José G. Merino, Steven Warach
SJR Q1NeurologyOA

BACKGROUND: Hyperintense vessels (HV) on fluid-attenuated inversion recovery imaging are frequently observed in acute ischemic stroke patients. However, the exact mechanism and clinical implications of this sign have not yet been clearly defined. The features of HV and its relevance to other imaging factors are presented here. METHODS: Prominence and location of HV were documented in 52 consecutive patients with middle cerebral artery (MCA) territory infarction, before treatment with IV recombin

EpidemiologyMedicine
2
Article|167 citations·2006
Early Recanalization After Intravenous Administration of Recombinant Tissue Plasminogen Activator as Assessed by Pre- and Post-Thrombolytic Angiography in Acute Ischemic Stroke Patients
Kyung‐Yul Lee, Sang Won Han, Seo Hyun Kim, Hyo Suk Nam, Sung Whan Ahn, Dong Joon Kim, Sang Hyun Seo, Dong Ik Kim, Ji Hoe Heo
SJR Q1StrokeOA

BACKGROUND AND PURPOSE: Recanalization rates after the intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment have been poorly studied in acute stroke. METHODS: CT angiography was performed before IV rt-PA in all patients and digital subtraction angiography was undertaken for intra-arterial thrombolysis in cases of no improvement after rt-PA infusion. RESULTS: Forty-five patients were treated with IV rt-PA. Initial CT angiography showed relevant arterial occlusions in 35 pat

EpidemiologyMedicine
3
Article|161 citations·2000
Arterial Pulsatility as an Index of Cerebral Microangiopathy in Diabetes
Kyung‐Yul Lee, Young H. Sohn, Jong Sam Baik, Gyung Whan Kim, Jin Soo Kim
SJR Q1StrokeOA

BACKGROUND AND PURPOSE: This study was designed to evaluate cerebral hemodynamic changes related to diabetes mellitus (DM) with transcranial Doppler ultrasonography (TCD). METHODS: We measured the flow velocities and the Gosling pulsatility index (PI) of the middle cerebral artery (MCA), extracranial internal carotid artery (ICA), and basilar artery (BA) in 56 stroke-free, normotensive patients with type 2 DM and 70 age- and gender-matched healthy volunteers. Patients were divided into 2 groups

Pulmonary and Respiratory MedicineMedicine
4
Article|85 citations·2004
Sequential combination of intravenous recombinant tissue plasminogen activator and intra-arterial urokinase in acute ischemic stroke.
Kyung‐Yul Lee, Dong Ik Kim, Seo Hyun Kim, Seung Ik Lee, Hae Woong Chung, Yong Woon Shim, Seung Min Kim, Ji Hoe Heo
PubMedOA

BACKGROUND AND PURPOSE: Combined intravenous (IV) and intra-arterial (IA) thrombolytic therapy may be faster and easier to initiate than monotherapy, and its recanalization rate may be better as well. The sequential combination of recombinant tissue plasminogen activator (rTPA) and urokinase (UK) has synergistic and complementary effects on clot lysis. We prospectively evaluated the effectiveness and safety of sequential combination of IV rTPA and IA UK in acute ischemic stroke. METHODS: IV rTPA

EpidemiologyMedicine
5
Article|59 citations·2018
Effect of statins on fasting glucose in non-diabetic individuals: nationwide population-based health examination in Korea
Jinkwon Kim, Hye Sun Lee, Kyung‐Yul Lee
SJR Q1Cardiovascular DiabetologyOA

More adherent and intensive use of statins was significantly associated with an increase in fasting glucose of non-diabetic individuals. In subgroup analysis of individual statins, use of atorvastatin, rosuvastatin, pitavastatin and simvastatin had significant association with increase in fasting glucose. Pravastatin, lovastatin, and fluvastatin had non-significant trend toward an increased fasting glucose. Our findings suggest the medication class effect of statins inducing hyperglycemia.

SurgeryMedicine
6
Article|56 citations·2018
Predictors of electronic word-of-mouth behavior on social networking sites in the United States and Korea: Cultural and social relationship variables
Kyung‐Yul Lee, Hojoon Choi
SJR Q1Computers in Human Behavior
Sociology and Political ScienceSocial Sciences
7
Article|52 citations·2004
Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis
Kyung‐Yul Lee, Eun Hee Kim, Won Seok Yang, Hyunjeong Ryu, Sang-Nae Cho, Byung In Lee, Ji Hoe Heo
SJR Q1Journal of the Neurological SciencesOA
OncologyMedicine
8
Article|46 citations·2001
Three cases of childhood nocturnal asthma due to buckwheat allergy
S. Y. Lee, K. S. Lee, C. H. Hong, Kyung‐Yul Lee
SJR Q1Allergy

BACKGROUND: Buckwheat flour (BF) is known as a potent food allergen. Sensitization to it usually occurs by ingestion but also by inhalation in occupational or domestic exposure. Buckwheat chaff-stuffed pillows (BCP) can be contaminated with BF during the process of pilling, and many Korean children and adults use BCP for health reasons. METHODS AND RESULTS: We here present three cases of BF allergy in children using BCP, who had been treated as nonatopic asthmatics after undergoing the routine a

Food ScienceAgricultural and Biological Sciences
9
Article|46 citations·2015
A High-Fat Diet Containing Lard Accelerates Prostate Cancer Progression and Reduces Survival Rate in Mice: Possible Contribution of Adipose Tissue-Derived Cytokines
Han Cho, Gyoo Taik Kwon, Heesook Park, Hyerim Song, Kyung‐Yul Lee, Jung-In Kim, Jung Han Yoon Park
SJR Q1NutrientsOA

To examine the effects of high-fat diet (HFD) containing lard on prostate cancer development and progression and its underlying mechanisms, transgenic adenocarcinoma mouse prostate (TRAMP) and TRAMP-C2 allograft models, as well as in vitro culture models, were employed. In TRAMP mice, HFD feeding increased the incidence of poorly differentiated carcinoma and decreased that of prostatic intraepithelial neoplasia in the dorsolateral lobes of the prostate, which was accompanied by increased express

Cancer ResearchBiochemistry, Genetics and Molecular Biology
10
Article|42 citations·2001
Rescue treatment with abciximab in acute ischemic stroke
Kyung‐Yul Lee, Ji Hoe Heo, Seung Ik Lee, Pyeong Ho Yoon
SJR Q1NeurologyOA

In acute ischemic stroke, reocclusion after an initially successful thrombolysis treatment can occur and is associated with increased morbidity and mortality. The authors present the successful use of abciximab, a platelet glycoprotein IIb/IIIa receptor inhibitor, in a patient with a thrombotic occlusion of the proximal middle cerebral artery, which was refractory to combined IV and intra-arterial thrombolysis and percutaneous intracranial balloon angioplasty.

EpidemiologyMedicine
11
Article|33 citations·2013
Acculturation Stress and Mental Health Among the Marriage Migrant Women in Busan, South Korea
Hyuk Im, Kyung‐Yul Lee, Hyo Young Lee
SJR Q1Community Mental Health Journal
Sociology and Political ScienceSocial Sciences
12
Article|33 citations·2013
Therapeutic Strategies for Well-differentiated Papillary Mesothelioma of the Peritoneum
Kyung‐Yul Lee, Hyun Jung Jun, Ji Hae Nahm, Tae Seop Lim, Ji Soo Park, Joong Bae Ahn, Sun Young Rha, Hyun Cheol Chung, Hwa Eun Oh, Jong Suk Song, Woo Ick Yang, Hyo Song Kim
SJR Q2Japanese Journal of Clinical OncologyOA

OBJECTIVE: Well-differentiated papillary mesothelioma is an uncommon subtype of mesothelioma with a frequently indolent course, although it occasionally manifests in a more aggressive form. To establish a treatment strategy for this rare disease, we report the clinical characteristics and outcomes of 15 patients with well-differentiated papillary mesothelioma. METHODS: All pathologically diagnosed well-differentiated papillary mesothelioma cases were reviewed between 1998 and 2012. RESULTS: Of t

Pulmonary and Respiratory MedicineMedicine
13
Article|32 citations·2000
Basilar artery vasospasm in postpartum cerebral angiopathy
Kyung‐Yul Lee, Young H. Sohn, Seo Hee Kim, Il‐Nam Sunwoo
SJR Q1NeurologyOA

The reason cerebral edema in postpartum cerebral angiopathy (PPCA) occurs preferentially in the posterior brain is poorly understood. The authors present two patients with PPCA who showed vasospasm occurring earlier and more severely in the basilar artery than in the middle cerebral artery. Our patients demonstrate the difference in vascular change between the anterior and posterior cerebral vessels, explaining the susceptibility of the posterior brain to PPCA.

NeurologyMedicine
14
Article|29 citations·2009
Inhibition of copper corrosion by modifying cysteine self‐assembled film with alkylamine/alkylacid compounds
Daquan Zhang, Liuling Gao, Qi-Rui Cai, Kyung‐Yul Lee
SJR Q2Materials and Corrosion

Abstract Complex self‐assembled monolayers (SAMs) were prepared by modifying the adsorption of cysteine with dodecylacid (DAC) and with dodecylamine (DAM) on copper surfaces. Their protective effects against copper corrosion were investigated by potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) in 0.5 M HCl aqueous solution. Results show that SAMs suppress cathodic current densities and shift the corrosion potential toward more negative values. Two types of com

Electrical and Electronic EngineeringEngineering
15
Article|25 citations·2018
Transanal Endoscopic and Transabdominal Robotic Total Mesorectal Excision for Mid-to-Low Rectal Cancer: Comparison of Short-term Postoperative and Oncologic Outcomes by Using a Case-Matched Analysis
Kyung‐Yul Lee, Jung Kyoung Shin, Yoon Ah Park, Seong Hyeon Yun, Jung Wook Huh, Yong Beom Cho, Hee Cheol Kim, Woo Yong Lee
SJR Q2Annals of ColoproctologyOA

Transanal endoscopic and transabdominal robotic TME showed similar histopathologic and postoperative outcomes with the exception of the estimated blood loss and the proximal resection margin for a select group of patients.

OncologyMedicine

Research Areas

EpidemiologyPulmonary and Respiratory MedicineCardiology and Cardiovascular MedicineNeurologySurgeryEndocrinology, Diabetes and Metabolism

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