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Lee Sang-hyub

Kyung Hee University · 医学

研究室紹介

Professor Lee Sang-hyub's research lab specializes in medicinal chemistry and translational oncology, focusing on the development of novel anticancer agents with improved pharmacological profiles. The lab investigates semisynthetic analogues of clinically relevant drugs such as mitomycin C and porfiromycin, aiming to enhance efficacy and reduce toxicity through strategic structural modifications. A key research direction involves designing prodrugs with redox-active functional groups—such as disulfide linkages—that enable targeted activation in tumor microenvironments. The lab also contributes to urological oncology research, particularly in optimizing surgical outcomes and understanding postoperative complications in renal and urothelial cancers.

anticancer drugsprodrug designmitomycin C analoguesrenal cancersurgical outcomes

Research Overview

Papers
99
Total Citations
1,774
Papers (5y)
16
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
16total
2022
2023
2024
2025
2026
Citations per year (5y)
65total
20222023202420252026

Selected Papers

15
1
Article|105 citations·2005
A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide
K. C. Nicolaou, Anthony A. Estrada, Mark Zak, Sang Hyub Lee, Brian S. Safina
Angewandte Chemie

Mild, selektiv und effizient: Eine neue Methode mit Trimethylzinnhydroxid zur Hydrolyse bestimmter Esterfunktionen vermeidet ungewollte Eliminierungen und Epimerisierungen. Beispielsweise wird der Ester 1 unter milden Bedingungen in die Carbonsäure 2 umgewandelt, wobei die stereochemische Integrität annähernd gewahrt wird. 1,2-DCE=1,2-Dichlorethan.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|58 citations·2015
Covered Metallic Stents With an Anti-Migration Design vs. Uncovered Stents for the Palliation of Malignant Gastric Outlet Obstruction: A Multicenter, Randomized Trial
Hyuk Lee, Byung‐Hoon Min, Jeong Hoon Lee, Cheol Min Shin, Younjoo Kim, Hyunsoo Chung, Sang Hyub Lee
SJR Q1The American Journal of Gastroenterology

WCS group showed comparable migration rate and significantly more durable long-term stent patency compared with UCS group for the palliation of GOO in patients with inoperable gastric cancer.

SurgeryMedicine
3
Article|46 citations·2014
3-Dimensionally disordered mesoporous silica (DMS)-containing mixed matrix membranes for CO2 and non-CO2 greenhouse gas separations
Sunghwan Park, Joona Bang, Jungkyu Choi, Sang Hyub Lee, Jung‐Hyun Lee, Jong Suk Lee
SJR Q1Separation and Purification Technology
Mechanical EngineeringEngineering
4
Article|23 citations·2004
Cyclic Disulfide C(8) Iminoporfiromycin: Nucleophilic Activation of a Porfiromycin
Sang Hyub Lee, Harold Kohn
SJR Q1Journal of the American Chemical Society

The clinical success of mitomycin C (1) and its associated toxicities and resistance have led to efforts to prepare semisynthetic analogues (i.e., KW-2149 (3), BMS-181174 (4)) that have improved pharmacological profiles. In this study, we report the preparation and evaluation of the novel 7-N-(1'-amino-4',5'-dithian-2'-yl)porfiromycin C(8) cyclized imine (6) and its reference compound, 7-N-(1'-aminocyclohex-2'-yl)porfiromycin C(8) cyclized imine (13). Porfiromycin 6 contains a disulfide unit tha

Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
Article|18 citations·2020
Differences between Risk Factors for Sepsis and Septic Shock in Obstructive Urolithiasis
Sang Hyub Lee, Taesoo Choi, Jeonghyouk Choi, Koo Han Yoo
SJR Q2Journal of Korean Medical ScienceOA

BACKGROUND: Complicated acute pyelonephritis (APN) is a life-threatening condition that requires immediate intervention. This study examined the characteristics of APN occurring as a complication of ureteral stone. METHODS: We retrospectively reviewed 85 patients diagnosed with APN complicated by ureteral stone between December 2006 and July 2017 at our institution. Patients with concomitant renal stone, multiple ureteral stones, ureteral strictures, ureteral cancer, and urogenital anomalies, in

Pulmonary and Respiratory MedicineMedicine
6
Article|17 citations·2021
Risk factors of febrile urinary tract infections following retrograde intrarenal surgery for renal stones
Dong Soo Kim, Koo Han Yoo, Seung Hyun Jeon, Sang Hyub Lee
SJR Q3MedicineOA

ABSTRACT: We aimed to evaluate the risk factors of febrile urinary tract infection (UTI) following retrograde intrarenal surgery (RIRS) for treating renal stones.We retrospectively reviewed the data of patients with 10 - 30 mm kidney stones who underwent RIRS from January 2014 to July 2017. Evaluation included age, gender, body mass index, stone size, stone location, and operative time. All surgeries were performed by a single surgeon and ureteral stenting was not done prior surgery. The risk fa

Pulmonary and Respiratory MedicineMedicine
7
Article|15 citations·2015
Comparison of postoperative estimated glomerular filtration rate between kidney donors and radical nephrectomy patients, and risk factors for postoperative chronic kidney disease
Sang Hyub Lee, Dong Soo Kim, Seok Cho, Sang Jin Kim, Seok Ho Kang, Jinsung Park, Sung Yul Park, Sung‐Goo Chang, Seung Hyun Jeon
SJR Q2International Journal of Urology

OBJECTIVES: To compare post-nephrectomy renal function between kidney donors and renal cell carcinoma patients, to evaluate trends in recovery, and to identify factors relevant to renal failure. METHODS: Patients who had radical or donor nephrectomy from four different institutions between 2003 and 2012 were reviewed. Propensity score matching was carried out and 79 patients were selected for each group. The estimated glomerular filtration rate was calculated using the Modification of Diet in Re

Pulmonary and Respiratory MedicineMedicine
8
Article|13 citations·2015
Robot-assisted laparoscopic retroperitoneal lymph node dissection for stage IIIb mixed germ cell testicular cancer after chemotherapy
Sang Hyub Lee, Dong Soo Kim, Sung‐Goo Chang, Seung Hyun Jeon
Korean journal of urologyOA

Laparoscopic retroperitoneal lymph node dissection, especially when performed with the da Vinci Surgical System (Intuitive Surgical), has shown excellent cosmetic results with similar oncologic outcomes to those of open surgery. In this study, we present a case of robot-assisted retroperitoneal lymph node dissection performed in an 18-year-old man who was diagnosed with a stage IIIb mixed germ cell tumor and who was initially treated with radical orchiectomy, followed by chemotherapy. This case

SurgeryMedicine
9
letter|11 citations·2016
Acute Idiopathic Scrotal Edema Caused by Epstein–Barr Virus
Sang Hyub Lee, Dong‐Gi Lee, Koo Han Yoo, Seung-Kwon Choi, Gyeong Eun Min, Hyung-Lae Lee
SJR Q1The Pediatric Infectious Disease Journal

To the Editor: Qvist1 first reported acute idiopathic scrotal edema (AISE) in 1956. No specific cause has been identified. Here, we discuss 2 cases of AISE caused by acute Epstein–Barr viral (EBV) infection. A 13-year-old male and a 6-year-old boy visited our hospital because of penile, scrotal and perineal swelling. Both of them reported no trauma to the perineal area and had never experienced an allergic reaction to any medications. Laboratory tests including urinalysis were normal. Penile and

RheumatologyMedicine
10
Article|11 citations·2013
Incontinence Pad Usage in Medical Welfare Facilities in Korea
Sang Hyub Lee, Ji-Soon Kang, Jeong-Wha Kim, Sun-Ju Lee
SJR Q2International Neurourology JournalOA

The prevalence of urinary incontinence in medical welfare facilities in Korea was about 65.3%. However, the management of urinary incontinence was insufficient. Urologists should make further efforts for the proper management of urinary incontinence in elders in these facilities.

RheumatologyMedicine
11
Article|10 citations·2014
Which Patients Should We Follow up beyond 5 Years after Definitive Therapy for Localized Renal Cell Carcinoma?
Sang Hyub Lee, Hee Seo Son, Seok Cho, Sang Jin Kim, Dae Seon Yoo, Seok Ho Kang, Sung Yul Park, Jinsung Park, Sung‐Goo Chang, Seung Hyun Jeon
SJR Q1Cancer Research and TreatmentOA

Patient age greater than 60 years, Fuhrman grade ≥ 3, and tumor stage ≥ pT2 are independent risk factors of recurrence more than 5 years after surgery in patients with RCC. Therefore, close lifelong follow-up is recommended for patients with these risk factors.

Pulmonary and Respiratory MedicineMedicine
12
Article|10 citations·2013
Incontinence Pad Usage in Medical Welfare Facilities in Korea
이상협, 강지순, 김정화, 이선주

Purpose: The prevalence of urinary incontinence and the usage of incontinence pads by elderly residents in Korean medical welfare facilities were investigated. Methods: From a total of 1,832 facilities, 33 medical welfare facilities in the capital area were randomly selected; all nursing homes were excluded. All data were collected by questionnaires to investigate the residents’ age and sex, the presence or absence of urinary incontinence, incontinence pad usage per month, and management methods

13
Article|7 citations·2017
Trends in Testicular Injury in Korea, 1986–2015
Sang Hyub Lee, Dong‐Gi Lee, Seung-Kwon Choi, Taesoo Choi, Koo Han Yoo
SJR Q2Journal of Korean Medical ScienceOA

The objectives of this study were to investigate patients treated for scrotal trauma at our institute for the last three decades to describe our experience with an emphasis on the etiologies and ultrasonographic findings in these patients. We reviewed medical records of patients who underwent scrotal ultrasonography for evaluation of testicular trauma at our institutes from 1986 to 2015. Trends regarding the etiology of scrotal trauma were evaluated during each decade. The echo pattern and conto

SurgeryMedicine
14
Article|5 citations·1998
Corticosteroid-induced Cataract
Sang Hyub Lee
SJR Q4Journal of the Korean Medical Association
Molecular BiologyBiochemistry, Genetics and Molecular Biology
15
editorial|5 citations·2021
Lasers for the treatment of urinary stone disease
Sang Hyub Lee, Seung Hyun Jeon
SJR Q1Investigative and Clinical UrologyOA
Pulmonary and Respiratory MedicineMedicine

Research Areas

Pulmonary and Respiratory MedicineSurgeryMolecular BiologyUrologyEpidemiologyOncology

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