Man Bock Gu
Korea University · 生化学・遺伝学・分子生物学
研究室紹介
Professor Man Bock Gu's research lab specializes in the development of advanced biosensors and nanomaterial-based platforms for biomedical and environmental applications. The lab focuses on aptamer discovery using innovative techniques like graphene oxide-based SELEX, enabling high-throughput, label-free detection of biomarkers and small molecules. Key research directions include the design of sensitive biosensors for disease diagnostics—such as those targeting RBP4 in type 2 diabetes—and the application of nanomaterials like silver and gold nanoparticles for probing cellular toxicity and ion homeostasis. The lab also explores enzyme immobilization strategies for sustainable biocatalysis and green energy production.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Every cell has a silver lining! The toxicity of Ag nanoparticles is investigated using a panel of recombinant bioluminescent bacteria. The presence of the nanoparticles leads to the production of a superoxide radical (see figure). Furthermore, the Ag nanoparticles damage the cellular membranes, causing a disruption in the ion efflux system. Thus, the cells cannot effectively extrude the Ag ions and, hence, Ag nanoparticles cause more damage than do Ag ions. Supporting information for this articl
Immobilization is a key technology for successful realization of enzyme‐based industrial processes, particularly for production of green and sustainable energy or chemicals from biomass‐derived catalytic conversion. Different methods to immobilize enzymes are critically reviewed. In principle, enzymes are immobilized via three major routes (i) binding to a support, (ii) encapsulation or entrapment, or (iii) cross‐linking (carrier free). As a result, immobilizing enzymes on certain supports can e
Graphene oxide (GO) has the ability to separate free short ssDNA in heterogeneous solution. This feature is applied as a label free platform for screening of aptamers that bind to their target with high affinity and specificity. Herein, we report an aptamer selection strategy for Nampt protein based on GO.
Retinol binding protein 4 (RBP4) is a useful biomarker in the diagnosis of type 2 diabetes since its level in the serum is higher in insulin-resistant states. Accurate measurement of the serum RBP4 levels is hampered by conventional immunologic methods, such as enzyme-linked immunosorbent assay (ELISA). In this study, therefore, we have developed an aptamer-based surface plasmon resonance (SPR) biosensor that can be used to sense for RBP4 in serum samples. A single-stranded DNA (ssDNA) aptamer t