Min-Jae Kim

Background/Aims: We explored the mechanisms underlying the improvement of postoperative ileus (POI) following probiotic pretreatment. We assessed intestinal permeability, inflammation, tight junction (TJ) protein expression in the gut epithelium, and plasma interleukin (IL)-17 levels in a guinea pig model of POI. Methods: Guinea pigs were divided into control, POI, and probiotic groups. The POI and probiotic groups underwent surgery, but the probiotic group received probiotics before the procedu

The purpose of this study is to examine the sleep environment, sleep quality and to reveal the relationship between sleep environment and obstructive sleep apnea hypopnea syndrome. The subjects of this study are twenty four women who live in an apartment in Seoul. We conducted pre-sleep questionnaire and post-sleep questionnaire. We measured equivalent noise level, illumination, air temperature, relative humidity, MRT, CO2 concentration, and AHI of each subject in their bedrooms. In case of both

BACKGROUND: Helicobacter pylori infection is a significant contributing factor of gastric cancer. Metachronous neoplasms also pose a risk. The mechanism underlying the impact of H. pylori eradication on preventing metachronous gastric cancer is unclear. This study aimed to investigate immunity changes in gastric mucosa after H. pylori eradication and to identify mechanisms preventing metachronous recurrence. MATERIALS AND METHODS: Patients diagnosed with gastric neoplasm and H. pylori infection,

The purpose of this study was to evaluate the association between type of physical activity(PA), sedentary time(ST) and lower back pain(LBP). Additionally, the association between lifestyle, demographic factors and lower back pain was investigated. A total of 1,781 subjects above 50 years of age who had participated in the Korean National Health and Nutrition Examination Survey(KNHANES) of 2014 were included for the analysis in this study. Chi-square test and univariable logistic regression were

Purpose We investigated the clinicopathologic information of patients with gastric cancer with multiple primary cancers (GC-MPC) of three or more sites. Materials and Methods Between 1995 and 2009, 105,908 patients were diagnosed with malignancy at Severance Hospital, Yonsei University Health System. Of these, 113 (0.1%) patients with MPC of three or more sites were registered, and 41 (36.3%) of these were GC-MPC. We retrospectively reviewed the clinical data and overall survival using the medic

As power demands increase, development of the superconducting fault current limiter (SFCL) is being watched with interest. Many types of SFCLs using various superconducting materials have been developed. Especially, the FCL using coated conductor (CC) has been investigated actively at present. CCs have many advantages for the FCL application. YBCO materials used in CCs have a high n-value, and it is relatively easy to choose a matrix of the CC for high resistivity. If the CC has high resistivity

Large critical current is one of the prerequisites for the design of superconducting electrical equipments with large power capacity. To enlarge the critical current, multiple parallel connection is inevitable. In multiple parallel superconducting coils, the difference in normal resistance of each shunt leads to unequal current distribution, which may yield burnout. Therefore, uniform current distribution is required for a stable operation of multiple parallel superconducting coils. In this pape

Background: Immune-mediated inflammatory diseases (IMIDs) are associated with chronic inflammation that may increase fracture risk; however, their impact within specific populations, such as those with type 2 diabetes mellitus (T2DM), remains unclear. This study aimed to evaluate the association between IMIDs and fracture risk, leveraging a large, high-quality population-based cohort of patients with T2DM. Methods: A total of 2,120,900 patients with T2DM without a previous history of fractures w

Postoperative ileus (POI) is a delay in gastrointestinal transit following surgery that leads to various complications. There is limited understanding of its effective treatment options. CKD-495 and eupacidin are natural products licensed for treating mucosal lesions in acute and chronic gastritis; however, little is known about their effects on intestinal permeability. This study evaluated the effects of CKD-495, eupacidin, and its components (eupatilin and cinnamic acid) on intestinal per-meab

Background/Aims: Achalasia is an esophageal motility disorder characterized by dysphagia and noncardiac chest pain. Impairment of vagal function has been reported in achalasia. This study evaluated autonomic nervous system (ANS) dysfunctions in patients with achalasia to establish a correlation between an ANS dysfunction and the clinical symptoms of achalasia. Methods: Nineteen patients with achalasia (six males/13 females; mean age, 47.1±16.3 years) and 10 healthy controls (four males/six femal

Coated conductor (CC) is recently inactively progress for the research and development, and its can be used various stabilizer for the specific superconducting applicat ions, coated conductor applied to superconducting fault current limiters(SFCLs) bypasses fault current to its stabilizer, where the surge is abruptly reduced; thus, stainless stel, which has large resistivity, can be a suitable stabilizer for SFCLs. Despite high n-value of the YBCO, CC stabilized with stainless steel did not effe

원자층 증착법(ALD: atomic layer deposition)으로 150oC에서 성장된 zinc oxide (ZnO) 초박막의 두께 변화에따른 구조적, 전기적, 광학적 특성을 조사하였다. ZnO 박막을 증착하기 위해 금속 전구체와 반응물로 각각 diethylzinc와deionized water를 사용하였다. ALD 사이클 당 성장률은 150 oC에서 약 0.21 nm/cycle로 일정 하였으며, 50 사이클 이하의 샘플들은 초기 ALD 성장 단계에서 상대적으로 얇은 두께로 인하여 비정질 성질을 갖는 것으로 보였다. 100 사이클에서 200 사이클로 두께가 증가함에 따라 ZnO 박막의 결정성이 증가하였고 hexagonal wurtzite 구조를 보였다. 또한, ZnO 박막의 입자 크기가 ALD 사이클의 수의 증가에 따라 증가되었다. 전기적 특성 분석 결과 박막 두께의 증가에 따라서 비저항 값이 감소하였으며, 이는 박막 두께 증가에 따른 입자 크기 증가 및 결정성 개선으로 더 두꺼

Colonoscopy-related adverse events in older adults were linked to frailty and medication use and were not dependent on age. This novel risk score supports personalized decision-making when performing colonoscopies in older adults.

본 논문은 모델 기반 강화학습(model-based reinforcement learning, MBRL)중 하나인 model-based policy optimization(MBPO)을 적용하여 one-hole one-ball(OHOB) patience 큐브 태스크를 해결하는 방법을 제안한다. OHOB patience 큐브 태스크는 하나의 작은 공을 큐브 내의 평면 위의 구멍에 넣는 문제로, 강화학습으로 푼다고 가정할 때 상태(state) 및 행동(action) 공간이 크고 정교한 정책(policy)이 요구되는 문제이다. 이에 따라, model-free RL(MFRL)로 이를 해결하기 위해서는 환경과 직접적으로 상호작용해서 얻어야 하는 샘플의 수가 매우 커지는 문제점이 있다. 대조적으로, MBRL은 학습을 통해 추정된 dynamics model을 활용하여 가상의 샘플 데이터를 생성함으로써, 환경과의 실제 상호작용 없이 샘플을 얻을 수 있게 되어 샘플링 효율을 크게 향상시킬 수 있다.