MyoungLae Cho
Kyung Hee University · 農学・生物学
研究室紹介
Professor MyoungLae Cho's research lab specializes in natural product chemistry and bioactive compound discovery, with a primary focus on marine algae and plant-derived compounds. The lab investigates the antioxidant, anti-diabetic, and neuroprotective activities of polysaccharides (e.g., fucoidan), phenolics, and flavonoids, emphasizing structure-activity relationships and functional properties. Key research directions include the isolation and characterization of bioactive molecules from seaweeds and medicinal plants, and their applications in food science and nutraceuticals.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The antioxidant activities of the ethanol (EtOH) extracts from the green seaweeds Enteromorpha compressa, Capsosiphon fulvescens, Chaetomorpha moniligera, and Ulva pertusa, as well as their solvent-partitioned fractions, were investigated, and their antioxidant activities were correlated with total phenolic and flavonoid contents. The EtOH extracts and their solvent-partitioned fractions showed 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl (OH•) radical scavenging activities with strong redu
The effect of fucoidan and its oversulfated derivative on starch digestibility was investigated by determining the enzymatic reaction kinetics and their inhibitory activity against α-amylase and amyloglucosidase. After the α-amylase hydrolysis, the produced reducing sugars of the buckwheat starch (BW, 2.0–3.0 g/100 mL) and those of the blends of BW with low levels of native fucoidan (NF, 0.5–1.0 g/100 mL) and oversulfated fucoidan (OSF, 0.5–1.0 g/100 mL) were in the range of 440–450 mg/g starch.
Eight compounds were isolated from the roots of Glycyrrhiza uralensis and tested for cholinesterase (ChE) and monoamine oxidase (MAO) inhibitory activities. The coumarin glycyrol (GC) effectively inhibited butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) with IC50 values of 7.22 and 14.77 µM, respectively, and also moderately inhibited MAO-B (29.48 µM). Six of the other seven compounds only weakly inhibited AChE and BChE, whereas liquiritin apioside moderately inhibited AChE (IC50 =
Abstract Rheological properties of fucoidan (F) and buckwheat starch (B) mixtures (3% or 6%) at different blending ratios of fucoidans (0, 0.1, 0.2, 0.5 and 1.0%) were investigated in steady and dynamic shear. Steady shear viscosity measurement revealed that aqueous pastes of the BF blends (3%, w/v) had a pseudoplastic and shear‐thinning behavior with flow behavior index ( n ) values of 0.61–0.68. The substitution of starch with fucoidan polymers significantly lowered the apparent viscosities co
This study investigated the influence of extraction conditions on antioxidant activities and catechin content from bark of Ulmus pumila. The U. pumila was extracted using various concentrations of ethanol (30, 50, 80, and 99 %) and different extraction times (1, 2, and 3 h) at 60 °C. The ethanol extracts were evaluated for their antioxidant activities [1,1-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activities and reducing power], total p
The EtOH extracts of red seaweeds (Symphyocladia latiuscula, Chondrus ocellatus and Carpopeltis affinis) and solvent partitioned fractions were investigated for their 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effects and the total phenolic contents were correlated with ABTS and DPPH radical scavenging activities. The EtOH extracts and their solvent partitioned fractions exhibited strong ABTS and DPPH radical scaveng