Sang-Hee Shim
Korea University · 材料科学
研究室紹介
Professor Sang-Hee Shim's research lab specializes in developing advanced optical and spectroscopic tools to visualize and understand the three-dimensional architecture of the genome and dynamic molecular processes in living cells. The lab focuses on super-resolution fluorescence microscopy, vibrational spectroscopy, and multimodal imaging techniques to study chromatin organization, gene regulation, and biomolecular interactions at nanoscale resolution. By integrating novel labeling strategies with cutting-edge optical methods, the lab aims to bridge molecular structure with cellular function in intact biological systems. Their work emphasizes innovation in label-free and multiplexed imaging to minimize sample perturbation and enhance specificity.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
2Recent advancements in sequencing and imaging technologies are providing new perspectives in solving the mystery of three-dimensional folding of genome in a nucleus. Chromosome conformation capture sequencing has discovered new chromatin structures such as topologically associated domains and loops in hundreds of kilobases. Super-resolution fluorescence microscopy with nanometer resolutions, in particular multiplexed approaches with sequence-specificity, has visualized chromatin structures from
Vibrational spectroscopy is a powerful tool for spectral imaging of biological samples, thanks to its narrow bandwidth (10 cm⁻¹) compared to fluorescence. Single-molecule vibrational spectroscopy has been demonstrated with near-field amplification as in surface-enhanced Raman spectroscopy or fluorescence detection as in stimulated Raman excited fluorescence and bond-selective fluorescence-detected infrared-excited spectro-microscopy. However, these methods often require elaborate sample preparat