Sang Ho Yu

To design artificial proteases that cleave peptide backbones of a wide range of proteins at selected sites, artificial active sites comprising the Cu(II) complex of cyclen (Cu(II)Cyc) and aldehyde group were synthesized on a cross-linked polystyrene. The aldehyde group was employed as the binding site in view of its ability of reversible formation of imine bonds with epsilon-amino groups of Lys residues exposed on the surface of proteins and Cu(II)Cyc as the catalytic group for peptide hydrolysi

Pork loin and belly cuts were pumped to 110% of their original weight with solutions containing 5% of various ingredients (sodium ascorbate, garlic, and onion powder), and evaluated the physicochemical properties, and antioxidant and antimicrobial activities during refrigerated storage at 8 degrees C. The addition of garlic and onion powder tended to increase redness (a) and yellowness (b) in both the belly lean and loin with the exception of a few cases. Free fatty acid values in both pork bell

Lipid oxidation and oxidative volatiles as affected by pork meat cut and packaging method during frozen storage at -10 degrees C were evaluated. Pork belly cut had higher thiobarbituric acid reactive substance (TBARS) and pH values than did the loin, whereas the loin had higher free fatty acid (FFA) values than that of the belly cut. Peroxide values increased with increased storage time, but were not affected by pork meat cut and packaging method. Volatiles with carbon numbers less than 10 in th

Lipid oxidation and oxidative products as affected by pork meat cut, packaging method, and storage time were evaluated during refrigerated storage. Pork belly had higher pH and thiobarbituric acid reactive substance (TBARS) values than pork loin, and aerobic-packaged belly had higher TBARS than vacuum-packaged counterparts. Loin had higher free fatty acid (FFA) values than belly, and increased FFA values were observed with increased storage time. Peroxide values increased up to 7 d and decreased

Antibiotic resistance in Escherichia coli is a global health concern. We studied all possible routes of cross contamination of broiler meat with resistant E. coli from broiler feces at poultry shops. Various sample categories namely poultry feces, meat (n=225 for each), slaughterer hands, consumer hands, slaughterer knife, canister, tap water, carcass, feed and drinking water (n=50 for each) were collected from local poultry processing market. Samples were screened for prevalence of E. coli, res

Although the guidelines may require a more detailed discussion after future advances in neuroscience and technology or changes in socio-cultural milieu, the development of the Korea Neuroethics Guidelines is a milestone for the scientific community and society in general for the ongoing development in neuroscience and neurotechnology.

오가자, 오디, 복분자 및 녹차로부터 폴리페놀 및 라디칼 소거능의 고효율 추출을 위한 추출조건을 반응표면분석법을 사용하여 최적화하였다. 중심합성계획에 따라 추출공정 조작변수인 에탄올 농도 및 추출온도를 독립변수로, 총 폴리페놀 함량, DPPH 및 ABTS 라디칼 소거능을 종속변수로 설정하여 이들의 종속변수의 값을 최대로 하는 공통의 조건을 최적조건으로 선정하였다. 추출물의 총 폴리페놀 함량과 라디칼 소거능에 미치는 용매의 에탄올 농도 및 온도는 유의적이었으며, 오가자 및 녹차의 모든 종속변수에 대한 반응표면모형은 유의적이었고, 오디의 라디칼 소거능에 대한 반응표면모형 또한 유의적이었다. 오디의 총 폴리페놀 함량 및 복분자의 총 폴리페놀 함량과 라디칼 소거능에 대한 반응표면모형은 적합하지 않았으며, 추출온도에 의한 일차적인 영향을 받는 것으로 나타났다. 최적조건에서 제조한 추출액의 총폴리페놀 함량 및 라디칼 소거능의 예측값과 실측값은 매우 유사한 값을 나타내어 본 연구에서 확립한 회귀

BACKGROUND: As large language models (LLMs) evolve, assessing their competence in ethically sensitive domains such as medical ethics has become increasingly important. Since medical ethics is a universal component of medical education, disparities in AI performance across languages may result in unequal benefits for learners. Therefore, it is essential to examine performances in non-English contexts. While previous studies have evaluated performance of Chat Generative Pre-trained Transformer(Cha

This qualitative study explored the role and limitations of families as mediators of medical communication among cancer patients in South Korea. Semi-structured interviews were conducted with 46 participants including patients, family members, doctors, and nurses. This study examined how families alleviate communication burdens and navigate power dynamics between patients and physicians. The findings revealed that families gather, interpret, and translate medical information, often acting as int

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In this paper, ethical principles and practice guidelines concerning the usage of public database for medical researches were developed and proposed. Although there are several personal health databases with comprehensive information of each individual, researches aiming at public good are often hindered because of legal, managerial and technical barriers to the usage of public databases. Ethical principles and guidelines are indispensible to promote medical research that will benefit society wh