Sangah Han
Kyung Hee University · 医学
研究室紹介
Professor Sangah Han's research lab focuses on molecular oncology and cancer genetics, with a primary emphasis on the regulation of tumor suppressor proteins and oncogenes in human cancers. The lab investigates post-translational modifications, such as ubiquitination, that control key regulators like pVHL and SKP2, and explores their roles in tumorigenesis, metastasis, and therapy response. Additionally, the lab examines genetic susceptibility and risk prediction in hereditary cancers, particularly BRCA1/BRCA2-related breast and ovarian cancers, as well as molecular markers in thyroid cancer, including BRAF mutations and FOSB gene polymorphisms. Their work integrates molecular biology, pathology, and clinical epidemiology to identify novel therapeutic targets and biomarkers.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The von Hippel-Lindau tumor suppressor pVHL is an E3 ligase that targets hypoxia-inducible factors (HIFs). Mutation of VHL results in HIF up-regulation and contributes to processes related to tumor progression such as invasion, metastasis, and angiogenesis. However, very little is known with regard to post-transcriptional regulation of pVHL. Here we show that WD repeat and SOCS box-containing protein 1 (WSB1) is a negative regulator of pVHL through WSB1's E3 ligase activity. Mechanistically, WSB
Atherosclerotic carotid stenosis (ACS) is a major cause of ischemic stroke. Screening for asymptomatic ACS is important to identify the patients who require longitudinal surveillance, medication, or endovascular surgery. The aim of this study was to assess the prevalence and risk factors for ACS and carotid plaque (CP) in Korea using a population-based screening study.We recruited participants during visits to several community welfare centers in Korea. The baseline characteristics of the study
ABSTRACT: An overexpression of S-phase kinase-associated protein 2 (SKP2) is frequently observed in human cancer progression and metastasis, and evidence suggests that SKP2 plays a proto-oncogenic role both in vitro and in vivo. However, the function of SKP2 in gastric adenocarcinoma remains largely obscure. We investigated SKP2 expression in human gastric carcinomas.Tissue samples were acquired from 182 cases of gastric adenocarcinoma that were surgically resected from 2006 to 2012. Immunohisto
trance) of breast and ovarian cancers among female family members with BRCA1 and BRCA2 mutation. Methods: Among the 61 BRCA1 mutation carriers in the 42 families and 47 BRCA2 mutation carriers in 31 families identified at 5 academic breast clinics, the probands were excluded to estimate the cumulative risk till each age of breast cancer in the Korean BRCA1 and BRCA2 carriers. Using Kaplan-Meier analyses, cumulative cancer risk estimates were determined. Results: By the age 70, the female breast