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Sangchul Park

Kyung Hee University · 生化学・遺伝学・分子生物学

研究室紹介

Professor Sangchul Park's research lab focuses on host-microbe interactions, particularly the role of the human microbiome and microbial extracellular vesicles in metabolic diseases such as type 2 diabetes. The lab also investigates microbial pathogenesis in honeybees, especially foulbrood diseases caused by *Paenibacillus larvae* and *Melissococcus plutonius*, with an emphasis on discovering novel antimicrobial agents. Using integrative 'omics' and bioinformatic approaches—including phylogenetic tree-based microbiome association tests and genomic prediction models—the lab advances precision medicine and sustainable apiculture solutions.

microbiomeextracellular vesiclesantimicrobial discoverygenomic predictionbee health

Research Overview

Papers
31
Total Citations
230
Papers (5y)
8
Primary Field
生化学・遺伝学・分子生物学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
8total
2020
2021
2022
2024
2025
Citations per year (5y)
60total
20202021202220242025

Selected Papers

15
1
Article|43 citations·2022
Role of an unclassified Lachnospiraceae in the pathogenesis of type 2 diabetes: a longitudinal study of the urine microbiome and metabolites
Kangjin Kim, Sanghun Lee, Sang-Chul Park, Nam-Eun Kim, Chol Shin, Seung Ku Lee, Youngae Jung, Dankyu Yoon, Hyeon-Jeong Kim, Sang‐Hyun Kim, Geum‐Sook Hwang, Sungho Won
SJR Q1Experimental & Molecular MedicineOA

Recent investigations have revealed that the human microbiome plays an essential role in the occurrence of type 2 diabetes (T2D). However, despite the importance of understanding the involvement of the microbiota throughout the body in T2D, most studies have focused specifically on the intestinal microbiota. Extracellular vesicles (EVs) have been recently found to provide important evidence regarding the mechanisms of T2D pathogenesis, as they act as key messengers between intestinal microorgani

Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|28 citations·2001
Immunobead RT-PCR versus regular RT-PCR amplification of CEA mRNA in peripheral blood
Seung‐Yoon Park, Byunghun Lee, Ik-Jung Kim, Inhak Choi, Kwan-Hee Hong, Yunsick Ryu, Jung-Hyo Rhim, Juhyun Shin, Sang-Chul Park, Hong-Keun Chung, Junho Chung
SJR Q1Journal of Cancer Research and Clinical OncologyOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
Article|27 citations·1982
Antimutagenic Activity of Chlorophyll to Direct- and Indirect-acting Mutagens and Its Contents in the Vegetables
Seung-Won Kimm, Bum-Suk Tchai, Sang-Chul Park, Surk-Ji Kang
SJR Q1Experimental & Molecular Medicine
General Agricultural and Biological SciencesAgricultural and Biological Sciences
4
Article|26 citations·2017
Immunomodulatory effects of soluble factors secreted by feline adipose tissue-derived mesenchymal stem cells
Hyung‐Kyu Chae, Woo‐Jin Song, Jin‐Ok Ahn, Qiang Li, Bo‐Yeon Lee, Kyeong Kweon, Sang-Chul Park, Hwa‐Young Youn
SJR Q2Veterinary Immunology and Immunopathology
GeneticsMedicine
5
Article|20 citations·2010
고용형태별 여행사종사원의 직무특성이 조직몰입에 미치는 영향 - 직무몰입의 매개변수 역할검증을 중심으로 -
김우진, 박상철, 이기종

본 연구는 고용형태별 여행사종사원의 조직몰입에 영향을 미칠 수 있는 여러 잠재적 요인들 가운데 연구의 초점을 그들의 직무몰입 수준에 맞추고 있다. 직무몰입은 그 자체가 선행변수로서 여행사종사원의 조직몰입에 직접적인 영향을 미칠 수도 있지만, 기술다양성, 과업정체성, 과업중요성, 직무자율성, 피드백경로 등 직무특성과 조직몰입 간의 인과관계에서 매개적인 역할을 나타낼 가능성도 있기 때문이다. 만약 여행사종사원들의 객관적인 직무특성 요인들 이외에 직무에 대한 몰입수준이 그들의 조직몰입에 직접적 혹은 간접적 영향을 미친다면, 여행사관리자들은 이들 종사원의 직무몰입 수준을 고려한 관리적 차원의 정책을 수행해야 할 것이다. 분석 결과를 요약하면 다음과 같다. 첫째, 직무특성적인 요인들 중에서 과업정체성과 과업중요성 그리고 피드백경로가 여행사종사원의 조직몰입을 결정하는데 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 직무특성적인 요인들 중에서 과업정체성, 과업중요성과 여행사종사원의 조직몰입 간

6
Article|19 citations·2019
Phylogenetic tree-based microbiome association test
Kangjin Kim, Jaehyun Park, Sang-Chul Park, Sungho Won
SJR Q1BioinformaticsOA

MOTIVATION: Ecological patterns of the human microbiota exhibit high inter-subject variation, with few operational taxonomic units (OTUs) shared across individuals. To overcome these issues, non-parametric approaches, such as the Mann-Whitney U-test and Wilcoxon rank-sum test, have often been used to identify OTUs associated with host diseases. However, these approaches only use the ranks of observed relative abundances, leading to information loss, and are associated with high false-negative ra

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|12 citations·2018
In vitro antibacterial activity of macelignan and corosolic acid against the bacterial bee pathogens Paenibacillus larvae and Melissococcus plutonius
Jaegoo Kim, Sang-Chul Park, Yu‐Kyong Shin, Hee Kyoung Kang, Ki‐Young Kim
SJR Q3Acta Veterinaria BrnoOA

Foulbrood disease, which is caused by Paenibacillus larvae (American foulbrood) or Melissococcus plutonius (European foulbrood disease), is a major threat to honeybees ( Apis mellifera ) worldwide. Tetracycline derivatives have been used to control these bacteria, but resistant strains have evolved, and the antibiotic derivatives can adversely affect bee health. When foulbrood disease is discovered, beekeepers usually burn the bee hives and equipment. The aim of this study was to investigate the

Insect ScienceAgricultural and Biological Sciences
8
Article|9 citations·1986
Promoter Modifies Carcinogenesis Process
Sang-Chul Park, Eung‐Gook Kim, Chong-Young Park, In-Hoo Kim, Jungho Han, Kye‐Yong Song, Bum-Suk Tchai, Seung-Won Kimm
SJR Q1Experimental & Molecular Medicine
EpidemiologyMedicine
9
Article|9 citations·2000
Reiterative transcription initiation from galP2 promoter of Escherichia coli
Nils Rostoks, Sang-Chul Park, Hyon E. Choy
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
GeneticsBiochemistry, Genetics and Molecular Biology
10
Article|8 citations·2024
Enhancing Genomic Prediction Accuracy for Body Conformation Traits in Korean Holstein Cattle
Jungjae Lee, Hyosik Mun, Yang Mo Koo, Sang-Chul Park, Junsoo Kim, Seongpil Yu, Jiseob Shin, Jae-Gu Lee, Jihyun Son, Chanhyuk Park, SeokHyun Lee, Hyungjun Song
SJR Q1AnimalsOA

The Holstein breed is the mainstay of dairy production in Korea. In this study, we evaluated the genomic prediction accuracy for body conformation traits in Korean Holstein cattle, using a range of π levels (0.75, 0.90, 0.99, and 0.995) in Bayesian methods (BayesB and BayesC). Focusing on 24 traits, we analyzed the impact of different π levels on prediction accuracy. We observed a general increase in accuracy at higher levels for specific traits, with variations depending on the Bayesian method

GeneticsBiochemistry, Genetics and Molecular Biology
11
Article|6 citations·2020
Antimicrobial activity of 4-hydroxyderricin, sophoraflavanone G, acetylshikonin, and kurarinone against the bee pathogenic bacteria Paenibacillus larvae and Melissococcus plutonius
Sang-Chul Park, Jaegoo Kim, Yu‐Kyong Shin, Ki‐Young Kim
SJR Q2Journal of Apicultural Research

The global number of bees has recently declined. One reason is pathogenic microorganisms including Paenibacillus larvae, which causes American foulbrood disease, and Melissococcus plutonius, which causes European foulbrood disease. The aim of this study was to identify new antimicrobial agents against foulbrood disease. Broth-microdilution assays with 20 natural compounds were used to detect the in vitro antimicrobial activity against foulbrood disease, and MTT assays were performed to determine

Insect ScienceAgricultural and Biological Sciences
12
Article|5 citations·1992
Purification of Sulfhydryl Oxidase from Human Foreskin Tissue and Immunohistochemical Localization
Sang-Chul Park, Hyemyung Seo, Sang-Gyu Lee, Woo Ho Kim, Kye‐Yong Song, Hee‐Chul Eun
Seoul National University Open Repository (Seoul National University)

Human sulfhydryl oxidase, catalyzing the conversion of either free or
\nbound thiol to disulfide compound, was isolated from human skin tissue to apparent
\nhomogeneity through multiple steps of ammonium sulfate salting-out, DEAE-cellulose
\nchromatography, CM-cellulose chromatography and ACA54 gel filtration. The enzyme
\nwas shown to have a molecular weight of 65 kDa and a specific activity of 8.39 x 103
\nUfmg protein. The specific polyclonal antibody was raised, with whic

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
Article|5 citations·2004
Correlation and Combining Ability of Plant Growth and Flowering in F_1 Hybrids by Diallel Cross in Lilium formolongi and L. formosanum
Cheon-Young Song, Sang-Chul Park, Jong-Suk Lee, Young‐A Kim, Jong-Hwa Kim
SJR Q3Horticultural Science and Technology

The correlation and combining abilities about growth and flowering characters were studied in the F_1s of 8 crosses from the partial four-parent diallel cross in Lilium formolongi and Lilium formosanum which were pure lines (S_6). The plant height showed highly positive correlation with stem diameter or internode length, and negative correlation with flower height. The flower diameter showed highly positive correlation with number of leaves, and negative correlation with internode length or flow

Plant ScienceAgricultural and Biological Sciences
14
Article|4 citations·1984
Purification of α-Fetoprotein from Human Cord Serum
Seung-Won Kimm, Bum-Suk Tchai, Hong-Keun Chung, Sang-Chul Park, Joo-Bae Park, Pann‐Ghill Suh, In‐Gyu Kim, Yong‐Sung Juhnn, Hyung‐Lae Kim
SJR Q1Experimental & Molecular Medicine
Molecular BiologyBiochemistry, Genetics and Molecular Biology
15
Article|3 citations·2016
Two-step Purification Method for Aging Pigments A2E and Iso-A2E Using Medium Pressure Liquid Chromatography
박상일, 박상철, 김소라, 장영표
http://onlinelibrary.wiley.com/doi/10.1002/bkcs.10903/abstract

Research Areas

Molecular BiologyGeneticsPlant ScienceInsect ScienceEpidemiologyFood Science

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