Seo-Ra Kim
Yonsei University · 医学
研究室紹介
Professor Seo-Ra Kim's research lab focuses on neuroprotective mechanisms in neurological disorders, particularly investigating natural compounds like ginsenosides in mitigating glutamate-induced neurodegeneration. The lab also explores clinical interventions in oncology, including desensitization protocols for chemotherapy-induced toxicity and surgical outcomes in cervical cancer. Additionally, the lab examines physiological responses to stressors such as hypovolemia and hyperoxia, with a focus on cardiovascular and autonomic regulation. A recurring theme is improving patient safety and treatment tolerance through mechanistic and translational research.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Kim YC, Kim SR, Markelonis GJ, Oh TH (1998): Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res 53:426–432. On page 427 of the article referenced above, under the heading Assessment of Neurotoxicity in the Materials and Methods section, the formula given for the assessment of percentage cell viability was printed incorrectly. The formula is correctly stated in a footnote to Table 1 on page 429. The correct formula appears below:
Many patients who experience oxaliplatin-induced IHSRs are required to stop first-line oxaliplatin-based chemotherapy or to continue without desensitization, with the associated risks. Our new desensitization protocol is practical and easy to use in clinical practice.
We tested the effect of 100% oxygen on heart rate (HR), arterial blood pressure (ABP), cardiac output (CO), stroke volume (SV), total peripheral resistance (TPR), HR variability (HRV), systolic blood pressure variability (SBPV) and baroreflex sensitivity (BRS) in 20 healthy volunteers during simulated haemorrhage induced by -40 mmHg lower body negative pressure (LBNP). HRV in the high frequency region (HRV HF), BRS, ABP and TPR were significantly increased, SBPV in the low frequency region (SBPV
Hand hygiene is the single most important intervention to combat infections in diverse health care settings. However, adherence to hand hygiene practice remains low among health care workers, especially in doctors.
<h3>Introduction/Background</h3> Mismatch repair deficiency (MMRd) is observed in 25–30% of all endometrial cancers. This can be detected by the absence of MMR protein staining on immunohistochemistry (IHC). Only 10% of women with MMRd have Lynch syndrome, but MMRd may still have prognostic significance. The objective of this study was to compare clinical outcomes between MMR deficient and proficient low-risk endometrioid endometrial cancers (stage IA, grade 1/2). <h3>Methodology</h3> This was a
Acanthopanax species are indigenous medicinal plant and the fruits of Acanthopanax species have been used as a remedy for “wipe out evil wind” in traditional medicine. Although there have been a few phytochemical studies on Acanthopanax fruits, no study on the comparison of anthocyanin contents and types between Acanthopanax species distributed in Korea was performed. In order to provide the phytochemical information about two major Acanthopanax species in Korea, Acanthopanax senticosus and Acan
Swarna (MTU7029), an Indian mega-variety of rice, is cultivated on an estimated 8Mha of land. There is a pressing need to address yield stagnation and wider adaptability to irrigated lowland and rainfed ecologies as a result of the negative consequences of climate change and population growth. The present study was aimed at improving Swarna for two yield-related traits through marker-assisted backcross breeding strategy by introgression of OsSPL14 (panicle branching) and SCM2 (stronger culm). Fo
On page 427 of the article referenced above, under the heading Assessment of Neurotoxicity in the Materials and Methods section, the formula given for the assessment of percentage cell viability was printed incorrectly.The formula is correctly stated in a footnote to Table 1 on page 429.The correct formula appears below: 100 (OD of glutamate ginsenoside-treated OD of glutamate-treated)/(OD of control OD of glutamate-treated).
<h3>Objectives</h3> The adverse effect of laparoscopic/robotic surgery in cervical cancer has been established, however the exact patient population that this applies to has not been fully elucidated. Our objective was to characterize the impact of surgical approach on outcomes in cases of no residual cervical cancer on hysterectomy specimen. <h3>Methods</h3> Retrospective cohort study of cases of surgically treated cervical cancer at 10 Canadian institutions from 2007–2019. Cases with no residu
Hye In Woo,1 Suk Ran Kim,2 Wooseong Huh,3,4 Jae-Wook Ko,4 Soo-Youn Lee4,5 1Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea; 2Clinical Research and Development, Hanmi Pharm. Co., Ltd., Seoul, Korea; 3Department of Medicine, 4Department of Clinical Pharmacology and Therapeutics, 5Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Background: Statin
Dong Woo Yeom,1 Ye Seul Song,1 Sung Rae Kim,1 Sang Gon Lee,1 Min Hyung Kang,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, Republic of Korea Abstract: In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were per