Seseon Kim
Korea University · 医学
研究室紹介
Professor Seseon Kim's research lab specializes in the development of advanced nanomaterials and bioimaging probes for biomedical applications, with a focus on designing smart, responsive nanosystems for real-time disease detection and therapeutic monitoring. The lab integrates synthetic chemistry, materials science, and molecular biology to create functional nanoparticles—such as conjugated polymer and chemiluminescent nanoprobes—that enable sensitive, in vivo imaging of biological processes like lymphatic mapping and endogenous hydrogen peroxide signaling. A key research direction involves understanding cellular responses to stress, such as hypoxia, through proteomic analysis, revealing critical regulatory mechanisms in endothelial and glial cells. The lab also investigates drug stability and pharmacokinetics, contributing to translational drug development.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Conjugated polymer nanoparticles, produced by in situ colloidal Knoevenagel polymerization, show advantageous properties (bright emission, colloidal/chemical stability and mesoscopic size range) that allow the successful in vivo application to real-time sentinel lymph node mapping in a mouse model.
Abstract Water‐dispersed all‐in‐one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near‐infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose l
Cytokines and growth factors are important regulatory proteins controlling the growth and differentiation of normal and malignant glial cells. In this study, we investigated the expression and origin of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta 1 (TGF-beta 1) in the subacute brain injury after a single high-dose irradiation using 60 Sprague-Dawley rats. The right cerebral hemispheres of rats were exposed to a single 10 Gy dose of gamma rays using Ir-192. The rad
In an oxygen-depleted environment, endothelial cells initiate an adaptive pattern of synthesis, which may enable them to survive hypoxic crises. Using high-resolution two-dimensional gel electrophoresis in conjunction with mass spectroscopy, we obtained a 24 differential display of proteins in the pancreatic endothelial cell line, MS-1, at four time points following induction of hypoxia. The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels. The phosphorylation of
In hybrid protocol, the Charité disc provided a relatively better restoration of ROM, than in the load control protocol, reproducing clinical observations in terms of motion following surgery.
The stability of DA-1131 after incubation in various pH solutions, human plasma, human urine, human gastric juice, rat liver homogenates and rat whole blood, the disappearance of DA-1131 after incubation in the 9000g supernatant fraction of various rat tissue homogenates in the presence of NADPH, the tissue distribution of DA-1131 after intravenous (i.v.) administration of DA-1131, 50 mg/kg, to rats, and the blood partition of DA-1131 between plasma and blood cells from rabbit blood were studied
Abstract Water‐dispersed all‐in‐one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near‐infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose l
Objective: To compare two testing protocols for evaluating range of motion (ROM) changes in the preloaded cadaveric spines implanted with a mobile core type Charité™ lumbar artificial disc. Methods: Using five human cadaveric lumbosacral spines (L2-S2), baseline ROMs were measured with a bending moment of 8 Nm for all motion modes (flexion/extension, lateral bending, and axial rotation) in intact spine. The ROM was tracked using a video-based motion-capturing system. After the Charité™ disc was
최근 코로나 이후 대한민국 온라인 쇼핑의 규모는 급격하게 성장 중이며, 이에 최초 해당 사이트의 마케팅 성격으로 시작된 멤버십이 이제는 고객과 회사 모두에게 중요한 영역이 되었지만, 이에 대한 실제적인 경험에 기초한 소비자의 지각된 자치와 이를 통한 재사용의도에 미치는 영향에 대한 연구는 부족한 상황이었다. 이에 본 연구는 유료 멤버십의 지각된 가치를 도출하고자 유료 멤버십 이용 경험이 있는 고객을 연구 대상자으로 총 500부의 설문지를 회수하여 실증분석을 수행하여, 지각된 가치 즉, 감정적 가치(Emotional Value), 경제적 가치(Economic Value), 브랜드 가치(Brand Value), 사회적 가치(Social Value), 편의적 가치(Convenience Value)가 고객 만족도에 미치는 영향을 검증해 보고 쇼핑몰의 만족도에 따라 유료 멤버십 서비스의 재사용 의도에 미치는 영향을 확인하였다. 연구의 결과로는 지각된 가치 중 경제적 가치, 편의적 가치, 브랜