Seung-ju Yoon
Korea University · 医学
研究室紹介
Professor Seung-ju Yoon's research lab specializes in anesthesiology and critical care medicine, focusing on the hemodynamic and metabolic responses during general anesthesia. The lab investigates anesthetic depth monitoring using advanced neuromonitoring tools such as the bispectral index (BIS) and entropy, aiming to optimize patient safety during surgery. Key research directions include the management of complications like malignant hyperthermia, propofol-induced lactic acidosis, and pain associated with intravenous anesthetic administration. The lab also explores hemodynamic stability during airway management using agents like remifentanil and esmolol, particularly in the context of rapid-sequence induction and critical care support.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Objective : Propofol and volatile anesthesia have been associated with metabolic acidosis induced by increased lactate. This study was designed to evaluate changes in pH, base excess (BE), and lactate in response to different anesthetic agents and to characterize propofol infusion-associated lactic acidosis. Methods : The medical records of patients undergoing neurosurgical anesthesia between January 2005 and September 2012 were examined. Patients were divided into 2 groups : those who received
Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants. MH is a rare and a potentially lethal disease, which can lead to cardiac arrest. We report a case of severe MH, in which the rapidly evolving signs of hypermetabolism eventually resulted in cardiac arrest. Despite conventional treatments following cardiopulmonary resuscitation, the patient’s v
Bispectral index (BIS) . Fourier (bispectral) (isoelectric EEG) 0, 100 . 1,2) BIS 40-65, (sedation) BIS 65-85 . 3) BIS . 1971 BIS 4) BIS . 1-7 sevoflurane
Background: We designed this double-blind, placebo-controlled study to compare the efficacy of remifentanil in reducing the pain of both propofol and rocuronium injection during rapid-sequence induction. Methods: Ninety-five patients, scheduled for elective surgery under general anesthesia, were divided into 3 groups:saline (Group S, n = 31), remifentanil 1 μg/kg (Group R, n = 32), and lidocaine 1.5 mg/kg (Group L, n = 32) were administered after tourniquet application. The occlusion was release
Background: Incorrect positioning of central venous catheter leads to serious complications. To prevent these complications, catheter tip should be at the superior vena cava and right atrial junction.
Background:The bispectral index (BIS) and entropy (response entropy, state entropy; RE, SE) have been used to monitor the anesthetic depth, and the difference between RE and SE (RE-SE difference) may represent the nociceptive stimuli during general anesthesia. This study was designed to determine whether BIS or entropy (RE, SE, and RE-SE difference) represent the response to tracheal intubation with iv bolus of remifentanil or esmolol for stable hemodynamic control during propofol anesthesia. Me
Psychological factors play a significant role in the pain mechanism, and psychological approaches may be useful complements to traditional medical and surgical treatments in pain management. The authors report a case of recurrent severe posterior auricular pain caused by trigger points in the right sternocleidomastoid muscle and influenced by stressful psychological situations (e.g., family affairs, job loss) in a 50-year-old man.
선천성심질환의 진단과 치료의 발전으로 선천성심질환을 가진 환자들 중 사춘기 및 성인에 이르기까지 생존하는 비 율이 증가하고 있다. 1) 최초의 수술로 심장 기형을 완전히 교정 받은 환자는 증상 없이 정상적인 심혈관계 소견을 보 이나 고식적수술이나 부분적교정술을 시행
Background : Sometimes hypoxemia occurs in the postoperative recovery room because of post- operative residual curarization (PORC). Some reports show that postoperative residual curarization is common. FORC occurs after the use of the long-acting muscle relaxants. It has been recommended to use intermediate-acting muscle relaxants and a TOF monitor to decrease PORC. The purpose of this study was to examine whether the use of the TOF monitor during propofol anesthesia affects the incidence of pos
Fever (body temperature above 38°C) is relatively common during the first few days after general anesthesia. Postoperative fever is usually caused by the inflammation induced by surgery and resolves spontaneously; however, it can be a manifestation of a serious complication such as malignant hyperthermia. We report a case of postoperative hyperthermia (body temperature > 40°C) that was refractory to conventional anti-pyretic measures and finally resolved with dantrolene administration.
Background: Pneumoperitoneum with an intra-abdominal pressure (IAP) of 14 mmHg is known to decrease renal function. Robotic-assisted radical prostatectomy (RARP) requires an IAP of more than 15 mmHg for operation. Therefore, we retrospectively investigated whether patients who underwent RARP experienced renal insufficiency during the postoperative period (at postoperative days 7 and 30). Methods: One hundred patients who underwent RARP were enrolled in this study. Preoperative serum blood urea n
This paper aims to examine the factors that affect the amount of official development assistance (ODA) a developing country receives for healthcare by the Korean government. We empirically tested to what extent the amount of Korea’s ODA in health care services, infrastructure,HIV/AIDS, and tuberculosis are affected by the relevant demand factors in the recipient countries. To do so, we carried out country-level multivariate regression analyses by setting the amount of ODA for four health care se
The occurrence of a pneumothorax during laparoscopy-assisted distal gastrectomy (LADG) is rare. A pneumothorax was developed during a LADG under general anesthesia in a 67-year-old woman with gastric cancer. About 140 minutes after CO2 insufflation, sudden hemodynamic collapse occurred. A defect was noted in the diaphragm. After immediate repair under laparoscopy, hemodynamic stability was achieved within several minutes. In the anesthetic management of a LADG, the anesthesia provider should be