Sok-Geun Choi
Kyung Hee University · 医学
研究室紹介
Professor Sok-Geun Choi's research lab focuses on neuroprotective mechanisms and innovative biomedical applications, particularly in the context of neurological disorders and neurodegenerative diseases. The lab investigates bioactive compounds like astaxanthin for their anti-inflammatory and antioxidant effects in neural cells, explores pharmacological interventions such as nimodipine in cerebral ischemia models, and develops advanced imaging and surgical techniques for neurological conditions. Additionally, the lab contributes to environmental and biomedical technology integration, including UAV-based vegetation monitoring and minimally invasive neurosurgical methods.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Astaxanthin has shown antioxidant, antitumor, and antiinflammatory activities; however, its molecular action and mechanism in the nervous system have yet to be elucidated. We examined the in vitro effects of astaxanthin on the production of nitric oxide (NO), as well as the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Astaxanthin inhibited the expression or formation of nitric oxide (NO), iNOS and COX-2 in li
This study investigated an efficient method for the extraction of astaxanthin from the red yeast Xanthophyllomyces dendrorhous. The extraction process comprised three steps: (1) cultivating the yeast; (2) treating the yeast culture suspension with microwaves to destroy the cell walls and microbodies; and (3) drying the yeast and extracting the astaxanthin pigment using ethanol, methanol, acetone, or a mixture of the three as the extraction solvent. Ultimately, various treatment tests were perfor
OBJECTIVE: Glutamate is a key excitatory neurotransmitter in the brain, and its excessive release plays a key role in the development of neuronal injury. In order to define the effect of nimodipine on glutamate release, we monitored extracellular glutamate release in real-time in a global ischemia rat model with eleven vessel occlusion. METHODS: TWELVE RATS WERE RANDOMLY DIVIDED INTO TWO GROUPS: the ischemia group and the nimodipine treatment group. The changes of extracellular glutamate level w
Since the use of UAV (Unmanned Aerial Vehicle) is convenient for the acquisition of data on broad or inaccessible regions, it is nowadays used to establish spatial information for various fields, such as the environment, ecosystem, forest, or for military purposes. In this study, the process of estimating FVC (Fractional Vegetation Cover), based on multi-spectral UAV, to overcome the limitations of conventional methods is suggested. Hence, we propose that the FVC map is generated by using multi-
Hemifacial spasm (HFS) is almost always induced by vascular compression but in some cases the cause of HFS are tumors at cerebellopontine angle (CPA) or vascular malformations. We present a rare case of hemifacial spasm caused by epidermoid tumors and the possible pathogenesis of HFS is discussed. A 36-year-old female patient presented with a 27-month history of progressive involuntary facial twitching and had been treated with acupuncture and herb medication. On imaging study, a mass lesion was