Soo Hyun Lee
Korea University · 医学
研究室紹介
Professor Soo Hyun Lee's research lab specializes in the development of smart biomaterials and targeted drug delivery systems for cancer therapy, with a focus on stimuli-responsive peptides, RNA-based nanocarriers, and hemostatic hydrogels. The lab explores innovative strategies such as enzyme-activated cell-penetrating peptides and functionalized chitosan derivatives to enhance drug specificity and reduce immune responses. A key research direction involves leveraging biological triggers—like bacterial azoreductase or endogenous enzymes—to enable precise spatiotemporal delivery of nucleic acid therapeutics to tumor sites. The lab also investigates the immunomodulatory tumor microenvironment, particularly regulatory T cells in aggressive cancers like triple-negative breast cancer.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The use of stimuli-responsive bioactive molecules is an attractive strategy to circumvent selectivity issues in vivo. Here, we report an activatable cell penetrating peptide (CPP) strategy ultimately aimed at delivering nucleic acid drugs to the colon mucosa using bacterial azoreductase as the local reconversion trigger. Through screening of a panel of CPPs, we identified a sequence (M918) capable of carrying a nucleic acid analogue payload. A modified M918 peptide conjugated to a peptide nuclei
BACKGROUND: Forkhead Box Protein 3 (FOXP3) is a marker for immunosuppressive CD4+CD25+ regulatory T cells (Tregs). We investigated whether there were significant numbers of FOXP3-positive Tregs in triple-negative breast cancer (TNBC) using immunohistochemistry, and whether the presence of FOXP3-positive Tregs was associated with other prognostic factors, such as stage or histologic grade. We investigated the number of tumor-infiltrating FOXP3-positive Tregs in formalin-fixed TNBC specimens obtai
BACKGROUND: The use of chemotherapy in advanced cancer patients has increased with the development of novel, high-efficacy anticancer therapeutic agents. In the current study, we analyzed the 10-year trends in patients receiving chemotherapy at the end of life. METHOD: We retrospectively reviewed mortality data for advanced cancer patients who died in 2000, 2005, and 2010 at a single institution. The trends of receiving palliative chemotherapy at the end of life were assessed for each year. In a
Chitosan-catechol, inspired from mussel-adhesive-proteins, is characterized by the formation of an adhesive membrane complex through instant bonding with serum proteins not found in chitosan. Using this intrinsic property, chitosan-catechol is widely applied for hemostatic needles, general hemostatic materials, nanoparticle composites, and 3D printing. Despite its versatility, the practical use of chitosan-catechol in the clinic is limited due to its undesired immune responses. Herein, a catecho
Because of RNA's ability to encode structure and functional information, researchers have fabricated diverse geometric structures from this polymer at the micro- and nanoscale. With their tunable structures, rigidity, and biocompatibility, novel two-dimensional and three-dimensional RNA structures can serve as a fundamental platform for biomedical applications, including engineered tissues, biosensors, and drug delivery vehicles. The discovery of the potential of small-interfering RNA (siRNA) ha
This nonequivalent control group pre-/posttest study investigated the effectiveness of a mindfulness-based stress reduction program at improving both the physical status and psychological status of 18 patients with metastatic breast cancer. The mindfulness-based stress reduction program had a mild effect of improving average pain and alleviating distress.