Sun-Young Lee

BACKGROUND AND OBJECTIVES: There have been considerable disagreements regarding the influence of MDR1 (ABCB1) polymorphisms on the disposition of P-glycoprotein (P-gp) substrates. We speculated that the unknown function of the A allele of exon 21 G2677T/A (Ala893Ser/Thr) provides one of the reasons for the contradictory results. This study was performed to clarify the effects of major MDR1 gene polymorphisms, including a variant A allele in exon 21, on fexofenadine pharmacokinetics. METHODS: We

Cholecystectomy alters the bile flow into the intestine and the enterohepatic circulation of the bile acids; this may affect the gut microbiota. We assessed the gut microbiota composition of patients who had undergone cholecystectomy and compared with those who had not. From a cohort of 1463 adult participants who underwent comprehensive health screening examinations, 27 subjects who had undergone cholecystectomy (cholecystectomy group) and 81 age- and sex-matched subjects who had not (control g

The prevalence of GX is 7% and it may be an increasing entity in Korea. Moreover, dyslipidemia and atrophic gastritis are found to be related to GX, but H pylori infection is not.

BACKGROUND: There are a few reports regarding the long-term results of endoscopic sphincterotomy (EST). However, little data is available on the recurrence of biliary symptoms after EST for choledocholithiasis, in patients with gall bladder stones. METHODS: All patients had gall bladder and common bile duct stones (n = 60; age 32-84 years, median age 55 years), and had received an EST. One group of these patients had a laparoscopic or open cholecystectomy (n = 39; group A), while the other group

The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC.

Clinical severity of scrub typhus ranges from mild to fatal. Acute pancreatitis with abscess formation is a rare complication among patients with scrub typhus. This paper reports a case of scrub typhus in a 75 years old man with acute pancreatitis with abscess formation and multiorgan failure. Abdominal computed tomography showed multiple infected pancreatic pseudocysts with peri-pancreatic infiltration. Multiorgan failure was successfully treated with doxycycline, ceftriaxone, and supportive ma

Abstract Colonoscopy is a safe and effective procedure to diagnose and treat the large bowel with the help of the flexible endoscope. This paper presents a new colonoscopy training simulator to help trainees practice and acquire the necessary skills and experiences with no risk to the patients and possibly less cost. The simulator includes a specialized haptic interface to transfer force feedback through a long and flexible tube, and graphics algorithms to display the virtual colon realistically

BACKGROUND AND AIMS: Midazolam is currently the most used sedative agent in endoscopy. The present study was designed to examine the appropriate dose of midazolam, time of initiation of endoscopy after midazolam infusion, and to prove the necessity of flumazenil as an antidote. METHODS: One hundred and eighty patients undergoing diagnostic gastroscopy were assigned three different amounts of intravenous midazolam in prospective, single-blinded and randomized setting as follows: (i) group I 0.03

The objective of this study is to determine whether targeted colonoscopy skills are acquired through simulation-based training using the KAIST-Ewha Colonoscopy Simulator II, and the acquired skills can be transferred to colonoscopy to actual patients. Eleven subjects consisting of six fellows and five residents participated in the study. The fellows and residents were divided into two groups, simulation-trained group and control group. Simulation-based training included practicing the targeted s

We report a case of microcystic (glycogen-rich) adenoma of the whole pancreas with coexistent pancreatic low-grade malignant islet cell tumor in a 29-year-old woman. She complained of nausea, vomiting, and growing abdominal mass. Abdominal computed tomography showed multiple cysts in the whole pancreas and a calcified solid mass in the pancreatic head. A Whipple's operation and total pancreatectomy with splenectomy was performed to treat pancreatic cystic neoplasm. The pancreas was entirely repl

본 연구는 인구통계학적 특성과 에너지교육 경험유무에 따른 에너지소비에 관한 소비자의 지식, 태도, 기능을 측정함으로써 현재 우리나라 소비자들의 에너지역량을 알아보는데 목적이 있다. 이를 위해 본 연구에서는 5점 척도의 자기기입식 설문지를 작성하여 전국의 20대-50대 남녀 소비자를 대상으로 데이터를 수집하였고, 수집된 데이터는 SPSS 14.0K for Windows 프로그램의 독립표본 T검증과 일원배치 분산분석(one-way ANOVA)을 이용하여 통계처리 하였다. 본 연구의 주요 결과는 다음과 같다. 에너지지식의 평균점수는 4.21이고, 에너지태도의 평균점수는 4.19이며, 에너지기능의 평균점수는 3.42이다. 이를 총합한 소비자의 에너지역량은 3.93으로 산출되었다. 인구통계학적 변수 중에서 에너지역량에 유의미한 차이를 보이는 요인은 연령, 결혼여부, 직업이었다. 연령이 높을수록 기혼일수록 에너지역량이 높았고, 학생이 가장 낮은 에너지역량을 보였다. 에너지교육경험 변수에 따른

The goal of this study is to validate the KAIST-Ewha Colonoscopy Simulation II as a training tool by examining the sectional learning curve of the trainees' performance on the simulation. Nine subjects including three fellows and six residents in the internal medicine participated in this study. All the subjects practiced the colonoscopy on the simulation until their performance surpasses the criteria preset by colonoscopy experts. Performance of the subjects during all the trials was measured i

BACKGROUND/OBJECTIVES: The traditional Korean diet is plant-based and rich in antioxidants. Previous studies have investigatedthe potential health benefits of individual nutrients of Korean foods. However, the cumulative effects of a Korean diet oninflammation remain poorly understood. Therefore, the aim of this study was to investigate the anti-inflammatory effects ofa plant-based Korean diet. MATERIALS/METHODS: Using data from the Fifth Korean National Health and Nutrition Examination Survey,

The gas disaster is the main minatory factor in coal mine. At present,the gas monitoring principally relies on the wire monitoring system which is hard to wire,easy to damage and high in cost. Therefore,an emergency wireless gas concentration acquisition system is proposed in this paper. It can be used for remote collection of underground gas concentration and other environmental parameters. This system includes acquisition front-end and receiving equipment. In actual application,the acquisition