Sung-Ha Park
Sungkyunkwan University · 物理学・天文学
研究室紹介
Professor Sung-Ha Park's research lab specializes in nanobiotechnology, focusing on the design, fabrication, and application of DNA-based nanostructures and hybrid nanomaterials. The lab explores DNA self-assembly for creating functional 1D and 2D nanostructures, such as open tubes and lattices, which are integrated with nanomaterials like carbon nanotubes and hydroxyapatite for sensing and biomedical applications. A key direction involves developing highly sensitive biosensors, including fiber-optic reflectance sensors using DNA thin films, for detecting bio-aerosols and biomolecules. The lab also investigates the integration of biopolymers and inorganic materials to create stable, functional coatings and composite films for advanced technological applications.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Polyvinyl alcohol (PVA) coated hydroxyapatite was deposited onto a 316L stainless steel substrate by electrophoretic deposition. Deposition was carried out in a methanol suspension at pH 5.5 using a graphite rod as an anode. Parameters such as PVA concentration, deposition voltage and time were optimized to achieve a homogeneous, crack-free adhesive coating. Techniques such as X-ray diffraction and Fourier transform infrared spectroscopy were used to study the phase composition of the coated mat
Although the intrinsic characteristics of DNA molecules and carbon nanotubes (CNT) are well known, fabrication methods and physical characteristics of CNT-embedded DNA thin films are rarely investigated. We report the construction and characterization of carboxyl (–COOH) group-modified multi-walled carbon nanotube (MWCNT–COOH)-embedded DNA and cetyltrimethyl-ammonium chloride-modified DNA (DNA–CTMA) composite thin films. Here, we examine the structural, compositional, chemical, spectroscopic, an
We present a simple but highly sensitive biotinylated DNA double crossover thin film coated fiber optic reflectance biosensor (DTF FORS) for the detection of streptavidin aerosols as a building block towards sensing bio-aerosols. The DNA double crossover lattice with biotin was dropped on the polymer optical fiber end face to prepare DNA Thin Film. The streptavidin aerosols were prepared using conventional aerosol technology. The DTF FORS response to streptavidin aerosol was few seconds and the
In the field of structural DNA nanotechnology, researchers create artificial DNA sequences to self-assemble into target molecular superstructures and nanostructures. The well-understood Watson–Crick base-pairing rules are used to encode assembly instructions directly into the DNA molecules. A wide variety of complex nanostructures has been created using this method. DNA directed self-assembly is now being adapted for use in the nanofabrication of functional structures for use in electronics, pho
Nanotechnology is one of the most important emerging fields of science in this century. It deals with designing, construction, investigation, and utilization of systems at the nanoscale. Another interesting research discipline of current day is biotechnology, which gives us a way to understand biological system and to utilize our knowledge for industrial manufacturing. Nanobiotechnology lies at the interface of these two research fields. It exploits nanotechnology and biotechnology to analyze an
DNA is one of the most promising molecules for use in nanotechnology because it has a nanoscale size and also has the ability for self-assembly. In this paper, we discuss the use of free-solution growth for a 1D DNA open tube (OT) and substrate-assisted growth for a 2D open lattice (OL), which can both achieve similar design schemes.We introduced biotinylated OT and OL, which can be bound with streptavidin for visualization, to verify via atomic force microscopy that dimensional structures have
We report the structural and functional stabilities of artificially synthesized DNA ultra-thin films. Fully covered DNA ultra-thin films on a silica substrate were fabricated by the silica-assisted growth method and those samples were then incubated in various chemicals and physical conditions. The DNA ultra-thin films showed high maintainability under those harsh conditions and these results would aid to facilitate the use of artificial DNA ultra-thin films in advanced research areas such as bi
This article reports the electrical characteristics of pristine, polycrystalline and single crystalline nickel (Ni) layer capped zinc oxide (ZnO) nanowires. Core/shell ZnO/Ni nanostructures were developed using chemical vapor deposition and e-beam evaporation, and the structures were annealed at different temperatures. Field effect transistor (FET) devices were fabricated using photolithography and investigated their characteristics at room temperature. All FET devices exhibited depletion-mode c
本文通过对现代汉语情态助动词“要”能否与主语同现的分析来考察“要”的语法特征。首先根据‘要’的情态意义来进行类型分类。其中,动力情态分为“意志”和“意图”;道义情态分为“强义务”和“弱义务”,“强义务”又分为“自然道理”和“环境要求”,“弱义务”又分为“劝告”,“命令”和“规范”;认识情态分为“常识”,“可能”,“推断”和“预测(复合预测,单纯预测)”。通过对以上各类的分析发现,动力情态不能与第二人称和非生命主语同现,道义情态中强义务与主语同现使用时所受到的制约比弱义务更多。而认识情态与动力情态及道义情态相比,所受到的制约相对较少。
The main aim of doping DNA lattices with lanthanide ions (Ln-DNA complex) is to change the physical functionalities for specific target applications such as electronics and biophotonics. LneDNA complexes based on a double-crossover DNA building block were fabricated on glass using a substrate-assisted growth method. We demonstrated the structural stability of LneDNA complexes as a function of Ln ion concentration by the atomic force microscopy. The Ln ion doping in DNA lattices was examined usin
A novel method of Surface Enhanced Raman Scattering (SERS) based molecular detection was developed using self-assembled DNA nanostructures. Molecule detection using rigid, shape-controllable DNA nanostructures provides significant advantages such as accurate control of the particle distance and geometrical programmability of the DNA nanostructure.We successfully detected the Cy3 dye, a Ramanactive molecule, at 1461, 1590, and 1619 cm-1 using a Ag-enhanced Au-DNA nanostructure. Consequently, DNA-
We present the photon induced conductivity of 2D DNA lattices with and without graphene and demonstrate the switching current responses controlled by light irradiation. The conductivity in the DNA lattices with protein streptavidin controlled by blue and white lights shows significant enhancement with the addition of graphene. An optical pulse response of a graphene immobilized DNA lattice is encouraging and may lead to various bio-sensing applications such as immunological assays, DNA forensics
In this study, we simultaneously grew different DNA nanostructures, including 5 helix ribbon (5HR), double-crossover (DX), and double-crossover with single hairpin (DX-SH) lattices, on a mica substrate, and we analyzed the concentration-dependent coverage percentages of 5HR at a fixed concentration of DX ([DX]), DX at a fixed [5HR], and DX-SH with both fixed [5HR] and [DX]. The structural features of the various nanostructures formed through mica-assisted growth annealing were confirmed via atom
本文通过对现代汉语"就要"、"快要"能否与其他语法成分共现的分析来考察"就要"、"快要"的语法特征的区别。首先根据"就要"、"快要"的情态意义来进行类型分析。其中,"就要"拥有动力情态、道义情态、认识情态,可是"快要"只有认识情态。这就是说明"就要"、"快要"的内部结构不一样,因此它们的语法特征也不一样。其次根据"就要"、"快要"的共现副词及时间词 来进行分析发现,"就要"注重事情的关连性和主观性,"快要"注重事情的时间性。最后根据"就要"、"快要"的共现助词"了"来进行分析发现,"快要"与"就要"相比,所受到的制约相对较少。通过对以上共现情况的分析发现,这些"快要"与"就要"共现情况的不同反映了它们的语法特征的不同。
This paper presents a strategy for the signal enhancement of surface plasmon resonance biosensors using colloidal gold nanoparticles and a silica layer. We describe the method for the deposition of a silica-stabilized gold nanoparticle layer on a gold film, namely an enhanced surface plasmon resonance chip. This chip shows significant changes in its surface plasmon resonance signals when biomolecules are attached to its surface as compared to a normal gold surface. These characteristics are clos