Sung Ho Hwang
Korea University · 医学
研究室紹介
Professor Sung Ho Hwang's research lab specializes in biomedical imaging and molecular oncology, focusing on the role of key regulatory proteins such as SIRT1 in cancer progression, particularly in lymphomas. The lab integrates molecular pathology with advanced medical imaging techniques—especially cardiac and pulmonary magnetic resonance imaging—to investigate disease mechanisms and improve diagnostic accuracy. Research also extends to the development of computational methods for verifying finite-state machine designs in biomedical systems, highlighting a multidisciplinary approach combining biology, medicine, and computer science. The lab emphasizes translational research, aiming to bridge molecular insights with clinical applications in oncology and cardiology.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma. Therefore, we investigated the prevalence and the prognostic impact of SIRT1 expression in diffuse large B-cell lymphoma (DLBCL). Immunohistochemical expression of SIRT1, p53, bcl2, CD10, bcl6, and multiple myeloma-1 (MUM1) were evaluated by using a 2 mm core from 104 DLBCL patients for tissue microarr
Because of the low positive predictive value of non-wedge-shaped, centrally located, early enhancing lesions in the diagnosis of HCC, the serial follow-up for examining lesion growth is essential to the correct diagnosis of small arterial hypervascular lesions in cirrhotic liver.
The correctness-checking problem of a finite-state machine is considered. The concept of machine cover is revived and used as the basis of the formulation of the verification problem of the design correctness of finite-state machines. The concept of machine cover enables the verifier to efficiently check the sufficiency. The verifier checks to see if the implementation is correct with respect to its specification, which is given as a form of finite-state machine. Since in general the state encod
Regardless of pulmonary disease pattern, TLC(CT) was smaller than pTLC, and it was more apparent in restrictive lung disease. Therefore, we should consider the difference between TLC(CT) and pTLC, as well as lung disease patterns of candidates, in lung size matching for LTx.
Magnetic resonance as an imaging modality provides an excellent soft tissue differentiation, which is an ideal choice for cardiac imaging. Cardiac magnetic resonance (CMR) allows myocardial tissue characterization, as well as comprehensive evaluation of the structures. Although late gadolinium enhancement after injection of the gadolinium extracellular contrast agent has further extended our ability to characterize the myocardial tissue, it also has limitations in the quantification of enhanced
Purpose To investigate the relationship between left atrial appendage (LAA) blood flow determined with cardiac magnetic resonance (MR) imaging and left atrial pressure (LAP) estimated from invasive catheter measurements in patients with atrial fibrillation (AF). Materials and Methods This retrospective study was approved by the institutional review board, and patients provided written informed consent. Seventy-seven patients with AF (mean age, 57.8 years ± 9.8; range, 31–76 years) underwent card
OBJECTIVE: We wanted to validate the additional merit of the thinner coronal reformation images from multidetector CT (MDCT) for making the diagnosis of hepatic cysts. MATERIALS AND METHODS: For the 90 benign hepatic cysts confirmed on MRI, the transverse (5-mm thickness) and additional coronal (2-mm thickness) reformation images from MDCT were compared with each other in terms of the Hounsfield units (HUs) and the size of each hepatic cyst. RESULTS: THE ATTENUATIONS (MEAN: 17.2 HUs, standard de