Tae-Sup Lim
Yonsei University · 医学
研究室紹介
Professor Tae-Sup Lim's research lab specializes in hepatology and gastroenterology, with a strong focus on liver disease management, particularly in chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC). The lab investigates diagnostic accuracy using tumor markers, non-invasive assessment of liver fibrosis and cirrhosis through elastography and ultrasonography, and long-term treatment outcomes, including renal safety of antiviral therapy. They also explore the links between muscle strength, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular risk, emphasizing real-world clinical applications and prognostic biomarkers.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Diagnostic accuracy improved upon combining the AFP, PIVKA-II, and AFP-L3 tumor markers compared to each marker alone in detecting HCC and early HCC in cirrhotic patients.
A higher DNI at the time of SBP diagnosis is an independent predictor of 30-day mortality in patients with SBP.
See the Original "Clinical application of ultrasonography-guided percutaneous liver biopsy and its safety over 18 years" on page 318.
Abstract In patients with chronic hepatitis B (CHB), long‐term effects of tenofovir disoproxil fumarate (TDF) on renal function have been controversial. This study aimed to analyse the real‐world long‐term effects of TDF on renal function in Korean patients with CHB. We analysed a cohort of 640 treatment‐naïve patients with CHB who were treated with TDF between May 2012 and December 2015 at Severance Hospital, Seoul, Republic of Korea. The mean age was 48.3 years old, and 59.5% were male. The pr
BACKGROUND: This study aimed to investigate the association between handgrip strength (HGS) and cardiovascular disease (CVD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) using data from the UK Biobank cohort. METHODS: A total of 201 563 participants were enrolled in this study. The HGS was measured using a Jamar J00105 hydraulic hand dynamometer. MASLD was defined as the presence of hepatic steatosis accompanied by one or more cardiometabolic criteria. Hep
Cirrhosis has prognostic value. We investigated whether the combined use of ultrasonography (US) and transient elastography (TE) to diagnose cirrhosis is beneficial for the risk assessment of hepatocellular carcinoma (HCC) and liver-related events in patients with chronic hepatitis B (CHB). A total of 9300 patients with CHB who underwent US and TE in two institutions between 2006 and 2018 were enrolled. TE value ≥13 kPa was set to indicate cirrhosis. Patients were divided into four groups: US(+)
Fibrotic burden in the liver differs across MAFLD subtypes. Optimized surveillance strategies and therapeutic options might be needed for different MAFLD subtypes.
Abstract The risk of developing hepatocellular carcinoma (HCC) after hepatitis B e antigen seroclearance (ESC) remains unclear. We established and validated a new risk prediction model for HCC development after ESC in patients with chronic hepatitis B (CHB) receiving antiviral therapy (AVT). Between 2006 and 2016, 769 patients (training cohort) and 1,061 patients (validation cohort) with CHB who experienced ESC during AVT using entecavir (ETV) or tenofovir disoproxil fumarate (TDF) were recruite
See the Original "Efficacy and safety of sofosbuvir-based regimens for treatment in chronic hepatitis C genotype 1 patients with moderately impaired renal function" on page 316.
, [1]. Vibrio cholerae, V. parahaemolyticus 5% [2]. V
A normal/underweight BMI and the presence of MASLD synergistically increased the risk of AD. The lean MASLD group had a higher risk of developing AD than the overweight/obese MASLD group, suggesting that the clinical relevance of MASLD for incident AD differs based on the BMI.
본 연구는 한국형 아파트 건물의 채광성능을 평가한 논문으로 우리나라에 대표적인 주거형태에 대한 채광성능을 공간별, 방위별, 천공조건에 변화에 의한 특성을 분석하는 것이 본 연구의 목적이다. 공간의 특성은 거실을 중심으로 침실1, 침실2, 주방이 위쪽에 위치하고 있고 안방이 거실의 개구부 방향과 동일하게 위치되어 있다. 침실2에는 발코니 공간이 있고 침실1에는 발코니가 없어 침실1과 침실2를 비교했을 때 발코니 유무에 따른 채광성능을 비교할 수 있다. 침실2와 주방은 모두 발코니가 있지만 개구부의 크기가 주방이 상대적으로 작다. 안방과 거실의 경우도 거실에는 발코니가 있지만 안방의 경우 전실공간이 없고 거실에 있는 발코니는 창문이 없는 것이 특징이다. 북쪽을 기준으로 거실의 방향을 0°～180°로 30°간격으로 변화하여 표준 담천공, 부분 담천공, 청천공 조건에서 채광성능을 비교, 분석하였다. 채광성능을 분석하는 연구툴로 Desktop RADIANCE 프로그램을 이용하여 조도와 균제도
Current Architectural Facade Designs have been trending to increased glass areas resulting in increasing impact on interior lighting and daylighting. In regards to indoor environmental quality, the increase in window space has a large impact on the daylighting received which ultimately impacts the liveability of a space. Especially when considering seasons, in the summer, excessive daylighting can result in glare as well as put an increased load in conditioning the air space further reducing ene