Vanessa Lim
Seoul National University · 生化学・遺伝学・分子生物学
研究室紹介
Professor Vanessa Lim’s research lab specializes in the intersection of molecular stereochemistry and rhetorical theory, exploring the physical principles underlying protein folding and the role of water shells in molecular recognition. The lab also investigates the rhetorical structures in early modern literature, particularly Shakespeare’s use of commonplaces and classical rhetorical traditions in plays like *Hamlet*. Through stereochemical modeling and textual analysis, the lab bridges biophysical mechanisms with humanistic inquiry, emphasizing the selectivity of molecular interactions and the intellectual culture of the Renaissance. Current work examines how structural constraints in biomolecules and rhetorical devices in literature both shape complex systems through underlying rules of organization and recognition.
Research Overview
Research Output Trend
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Selected Papers
15The authors analyze the physical prerequisites on which the proposed stereochemical theory of the three-dimensional structure of globular proteins is based. The theory represents a stereochemical modelling of the mechanism of protein self-organization suggested earlier by one of the authors. According to this mechanism, a highly helical intermediate structure(s) is formed at first and then it passes into the native one. In the highly-helical intermediate structure the arrangement of the polypept
It is shown within the framework of stereochemical modeling that disruption of water shells of proteins and nucleic acids is confronted by significant kinetic barriers caused by the breaking of hydrogen bonds. The structure of the water shells is dictated by the surface of proteins and nucleic acids, therefore the kinetic barriers due to disruption of the water shell are strongly distinct from each other on different parts of the shell. This, in turn, means that the probability of participation
Abstract Hamlet’s ‘To be or not to be’ speech has long been the subject of intense scholarly attention. By situating the speech against the backdrop of classical and Renaissance rhetorical theory, this essay demonstrates that there is still much more to be said about it. The speech ostensibly examines a quaestio infinita or a thesis, and follows the rhetorical rule that the right way to do so is by the invocation of commonplaces. This reading of Hamlet’s speech is not only consistent with Shakes