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Won-ji Yoo

Yonsei University · 医学

研究室紹介

Professor Won-ji Yoo's research lab specializes in translational biomedical research, focusing on neuromuscular rehabilitation, neurodegenerative disease prevention, and molecular diagnostics in chronic inflammatory and neurological conditions. The lab investigates innovative biofeedback technologies—particularly EMG-virtual reality integration—for improving motor control in children with cerebral palsy, while also exploring biomarkers like NPTX2 hypermethylation for early pancreatic cancer detection. Additionally, the lab examines the long-term health impacts of chronic diseases such as systemic lupus erythematosus, particularly the role of medications like hydroxychloroquine in modulating cardiovascular and metabolic risks. Their work bridges clinical neurology, rehabilitation engineering, and molecular diagnostics to develop non-invasive, personalized interventions.

neuromuscular rehabilitationbiofeedback systemspancreatic cancer biomarkersdementia risk factorssystemic lupus erythematosus

Research Overview

Papers
189
Total Citations
2,173
Papers (5y)
46
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
46total
2022
2023
2024
2025
2026
Citations per year (5y)
136total
20222023202420252026

Selected Papers

15
1
Review|63 citations·2018
Association between residual teeth number in later life and incidence of dementia: A systematic review and meta-analysis
Bumjo Oh, Dong‐Hun Han, Kyu‐Tae Han, Xibei Liu, Johnson Ukken, Carina Chang, Kiki Dounis, Ji Won Yoo
SJR Q1BMC GeriatricsOA

Despite limited scientific strength, the current meta-analysis reported that a higher number of residual teeth was associated with having a lower risk of dementia occurrence in later life.

PeriodonticsDentistry
2
Article|62 citations·2014
Effects of innovative virtual reality game and EMG biofeedback on neuromotor control in cerebral palsy
Ji Won Yoo, Dong Ryul Lee, Yon Ju Sim, Joshua H. You, Cheol J. Kim
SJR Q3Bio-Medical Materials and EngineeringOA

Sensorimotor control dysfunction or dyskinesia is a hallmark of neuromuscular impairment in children with cerebral palsy (CP), and is often implicated in reaching and grasping deficiencies due to a neuromuscular imbalance between the triceps and biceps. To mitigate such muscle imbalances, an innovative electromyography (EMG)-virtual reality (VR) biofeedback system were designed to provide accurate information about muscle activation and motivation. However, the clinical efficacy of this approach

Psychiatry and Mental healthMedicine
3
Review|55 citations·2017
Favorable effects of hydroxychloroquine on serum low density lipid in patients with systemic lupus erythematosus: A systematic review and meta‐analysis
Hamayon Babary, Xibei Liu, Yosef Ayatollahi, Xin P. Chen, Loomee Doo, Lakshmi K. Uppaluru, Myoung Kwan Kwak, Catherine Kulaga, Dodji Modjinou, Ewa Olech, Ji Won Yoo
SJR Q3International Journal of Rheumatic DiseasesOA

Abstract Aims Hydroxychloroquine ( HCQ ) has shown to have significant immunomodulatory effects in the treatment of systemic lupus erythematosus ( SLE ). Current studies show favorable effects of HCQ on traditional cardiac risk factors in patients with SLE . This review examined the effects of HCQ on serum low‐density lipoprotein ( LDL ) level in patients with SLE . Methods A systematic search of seven major literature search databases from their inception until 3 April, 2017 identified nine stu

RheumatologyMedicine
4
Article|51 citations·2008
Preventive Effects of Ulinastatin on Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in High-Risk Patients
Ji Won Yoo, Ji Kon Ryu, Sang Hyub Lee, Sang Myung Woo, Joo Kyung Park, Won Jae Yoon, Jun Kyu Lee, Kwang Hyuck Lee, Jin‐Hyeok Hwang, Yong‐Tae Kim, Yong Bum Yoon
SJR Q2Pancreas

Low-dose prophylactic treatment with ulinastatin immediately after ERCP did not show a beneficial influence on the incidence of post-ERCP pancreatitis and hyperamylasemia in high-risk patients.

Pulmonary and Respiratory MedicineMedicine
5
Article|47 citations·2017
Augmented effects of EMG biofeedback interfaced with virtual reality on neuromuscular control and movement coordination during reaching in children with cerebral palsy
Ji Won Yoo, Dong Ryul Lee, Young Su Joo, Sung Hyun You
SJR Q2Neurorehabilitation

BACKGROUND: The purpose of the present study was to compare therapeutic effects of an electromyography (EMG) biofeedback augmented by virtual reality (VR) and EMG biofeedback alone on the triceps and biceps (T:B) muscle activity imbalance and elbow joint movement coordination during a reaching motor taskOBJECTIVE: To compare therapeutic effects of an electromyography (EMG) biofeedback augmented by virtual reality (VR) and EMG biofeedback alone on the triceps and biceps muscle activity imbalance

Psychiatry and Mental healthMedicine
6
Article|39 citations·2007
Quantitative Analysis of NPTX2 Hypermethylation Is a Promising Molecular Diagnostic Marker for Pancreatic Cancer
Joo Kyung Park, Ji Kon Ryu, Kwang Hyuk Lee, Jun Kyu Lee, Won Jae Yoon, Sang Hyub Lee, Ji Won Yoo, Sang Myung Woo, Gyung Yub Lee, Cheol‐Ho Lee, Yong‐Tae Kim, Yong Bum Yoon
SJR Q2Pancreas

The quantitative analysis of NPTX2 hypermethylation may play a role in making highly sensitive and less invasive diagnosis of pancreatic cancer. Therefore, NPTX2 hypermethylation could be a promising molecular diagnostic marker.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Review|37 citations·2017
Effects of hospital palliative care on health, length of stay, and in-hospital mortality across intensive and non-intensive-care units: A systematic review and metaanalysis
Xibei Liu, Yaser Dawod, Alex Wonnaparhown, Amaan Shafi, Loomee Doo, Ji Won Yoo, Eunjeong Ko, Youn Seon Choi
SJR Q2Palliative & Supportive Care

OBJECTIVE: Hospital palliative care has been shown to improve quality of life and optimize hospital utilization for seriously ill patients who need intensive care. The present review examined whether hospital palliative care in intensive care (ICU) and non-ICU settings will influence hospital length of stay and in-hospital mortality. METHOD: A systematic search of CINAHL/EBSCO, the Cochrane Library, Google Scholar, MEDLINE/Ovid, PubMed, and the Web of Science through 12 October 2016 identified 1

Public Health, Environmental and Occupational HealthMedicine
8
Article|33 citations·2013
The Association Between Quality of Care and Quality of Life in Long-Stay Nursing Home Residents With Preserved Cognition
Sun Jung Kim, Eun‐Cheol Park, Sulgi Kim, Shunichi Nakagawa, John Lung, Jong Bum Choi, Woo Sang Ryu, Too Jae Min, Hyun Phil Shin, Kyudam Kim, Ji Won Yoo
SJR Q1Journal of the American Medical Directors AssociationOA
General Health ProfessionsHealth Professions
9
Article|30 citations·2019
Dissociation between the growing opioid demands and drug policy directions among the U.S. older adults with degenerative joint diseases
Pearl Kim, Takashi Yamashita, Jay J. Shen, Seong-Min Park, Sung‐Youn Chun, Sun Jung Kim, Jinwook Hwang, Se Won Lee, Georgia Dounis, Hee‐Taik Kang, Yong‐Jae Lee, Dong‐Hun Han
SJR Q3MedicineOA

We aim to examine temporal trends of orthopedic operations and opioid-related hospital stays among seniors in the nation and states of Oregon and Washington where marijuana legalization was accepted earlier than any others.As aging society advances in the United States (U.S.), orthopedic operations and opioid-related hospital stays among seniors increase in the nation.A serial cross-sectional cohort study using the healthcare cost and utilization project fast stats from 2006 through 2015 measure

Public Health, Environmental and Occupational HealthMedicine
10
Article|23 citations·2017
Effects of the 2009 Medical Cannabinoid Legalization Policy on Hospital Use for Cannabinoid Dependency and Persistent Vomiting
Mustafa Al-Shammari, Karina Herrera, Xibei Liu, Brandon Gisi, Takashi Yamashita, Kyu‐Tae Han, Mohamed Azab, Harmeet S. Mashiana, Muthena Maklad, Muhammad T. Farooqui, Ranjit Makar, Ji Won Yoo
SJR Q1Clinical Gastroenterology and HepatologyOA
PharmacologyMedicine
11
Review|22 citations·2015
Hospital Readmission of Skilled Nursing Facility Residents: A Systematic Review
Ji Won Yoo, Sanjeeda Jabeen, Tanvir Bajwa, Sun Jung Kim, David Leander, Laila Hasan, Jodi Punke, Soryal Soryal, Ariba Khan
SJR Q2Research in Gerontological Nursing

Hospital readmission of patients discharged to skilled nursing facilities (SNFs) is common and costly with increasing public attention over the past decade, particularly in light of the new health care environment surrounding the advent of the Affordable Care Act. The purpose of the current systematic review is to critically examine prevalence, predictors, and costs of hospital readmission of SNF residents found in the medical literature. Individual resident, facility, and intervention factors p

General Health ProfessionsHealth Professions
12
Article|20 citations·2020
Regional variation in states’ naloxone accessibility laws in association with opioid overdose death rates-Observational study (STROBE compliant)
Hyo‐Sun You, Jane Ha, Cyra-Y. Kang, Leeseul Kim, Jinah Kim, Jay J. Shen, Seong-Min Park, Sung‐Youn Chun, Jinwook Hwang, Takashi Yamashita, Se Won Lee, Georgia Dounis
SJR Q3MedicineOA

Though overall death from opioid overdose are increasing in the United States, the death rate in some states and population groups is stabilizing or even decreasing. Several states have enacted a Naloxone Accessibility Laws to increase naloxone availability as an opioid antidote. The extent to which these laws permit layperson distribution and possession varies. The aim of this study is to investigate differences in provisions of Naloxone Accessibility Laws by states mainly in the Northeast and

Public Health, Environmental and Occupational HealthMedicine
13
Article|18 citations·2013
Effects of hospitalist‐directed interdisciplinary medicine floor service on hospital outcomes for seniors with acute medical illness
Ji Won Yoo, Haesun Seol, Sun Jung Kim, Janet Yang, Woo Sang Ryu, Too Dae Min, Jong Bum Choi, Minkyung Kwon, Sulgi Kim
SJR Q2Geriatrics and gerontology international/Geriatrics & gerontology internationalOA

AIM: To examine whether a hospitalist-directed interdisciplinary (ITD) team in an internal medicine residency program enhances the hospital and clinical outcomes for seniors with acute medical illness. METHODS: Seniors admitted to a USA teaching hospital medical floor-teaching services were allocated to the ITD (n = 379) and usual care teams (n = 383). Compared with the usual care team, the ITD team physicians carried out daily "geriatric" assessment and management, and led ITD team meetings. RE

Emergency MedicineMedicine
14
Article|18 citations·2012
Integrative Palliative Care, Advance Directives, and Hospital Outcomes of Critically Ill Older Adults
Ji Won Yoo, Shunichi Nakagawa, Sulgi Kim
SJR Q2American Journal of Hospice and Palliative Medicine®

OBJECTIVE: To examine the associations between palliative care types and hospital outcomes for patients who have or do not have advance directives. METHOD: Using administrative claims and clinical data for critically ill older adults (n = 1291), multivariable regressions examined the associations between palliative care types and hospital outcomes by advance directive status. RESULTS: Integrative palliative care was associated with lower hospital costs, lower adjusted probability of in-hospital

Public Health, Environmental and Occupational HealthMedicine
15
Article|16 citations·2012
Delirium and transition to a nursing home of hospitalized older adults: A controlled trial of assessing the interdisciplinary team‐based “geriatric” care and care coordination by non‐geriatrics specialist physicians
Ji Won Yoo, Shunichi Nakagawa, Sulgi Kim
SJR Q2Geriatrics and gerontology international/Geriatrics & gerontology international

AIM: To examine whether a team-based inpatient "geriatric" care model provided by non-geriatrics specialist physicians was associated with changes in the occurrence of delirium and transition to a nursing home. METHODS: We carried out an intervention (interdisciplinary; ITD group) control (usual care group) study comparing the outcomes of hospitalized older adults cared for by non-geriatrics specialist physicians. Compared with the usual care group, the ITD intervention group provided additional

Critical Care and Intensive Care MedicineMedicine

Research Areas

Public Health, Environmental and Occupational HealthGeneral Health ProfessionsPulmonary and Respiratory MedicinePharmacologyHepatologyOncology

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