Yong-Seok Lee
Seoul National University · 医学
研究室紹介
Professor Yong-Seok Lee's research lab specializes in innate immunity and signal transduction mechanisms in invertebrates and prokaryotes, with a focus on protease cascades, pattern recognition, and receptor activation. The lab investigates molecular mechanisms underlying immune responses, particularly the regulation of phenoloxidase activation in insects and the structural basis of signal transduction in response regulators and TLR2 ligands. Key research directions include the structural and functional characterization of key immune enzymes and receptors, such as Spätzle-processing enzymes, CheY-like receiver domains, and bacterial lipoproteins.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between the TyG index and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS). We included consecutive patients diagnosed with AIS between 2010 and 2016. ERILs were defined as new diffusion-weighted imaging lesions outside the initial symptomatic lesion area. The TyG index was calculated using the following f
BACKGROUND: Aspirin is a proven antiplatelet agent in acute ischemic stroke, and there are no current guidelines for other antiplatelet treatments. We aimed to compare the efficacy and safety of cilostazol with aspirin in acute stroke. METHODS: Patients with measurable neurological deficits (NIHSS score ≤15) within 48 h of onset were randomly assigned to cilostazol (200 mg/day) or aspirin (300 mg/day) for 90 days. The primary endpoint was a modified Rankin Scale (mRS) score of 0-2 at 90 days. Ca
Immediate and optimal management seems to modify the risk of recurrent stroke after TIA. Cerebral microbleeds may be novel predictors of stroke recurrence, which needs further validation.
BACKGROUND: Stroke-associated pneumonia (SAP) is common in patients with acute ischemic stroke, and several risk factors have been reported. However, the relationship between underlying leukoaraiosis (LA) and SAP has not been addressed. METHODS: We collected consecutive patients with acute ischemic stroke within 24 h of symptom onset. SAP was defined as the lower respiratory tract infection within the first 7 days after stroke onset, according to the modified Centers for Disease Control and Prev
BACKGROUND: Initial D-dimer level is a well-known prognostic parameter in patients with acute ischemic stroke (AIS). However, there have been no studies on the clinical significance of follow-up D-dimer levels. In this study, we evaluated the association between initial and follow-up D-dimer levels and early neurological deterioration (END) in patients with AIS. METHODS: We included consecutive patients with AIS who had a positive initial D-dimer test (> 0.55 mg/L) between March 2021 and Novembe
Ipsilateral PI is closely associated with cSVD in patients with lacunar stroke. Furthermore, this association is different between subtypes of cSVD, which is suggestive of underlying pathophysiological differences.
Reduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but the underlying mechanism was not elucidated. We investigated the association among OSA, cerebrovascular compliance, and SVD parameters. This study retrospectively included individuals ≥ 50 years of age, underwent overnight polysomnographic (PSG) for the evaluation of OSA, and performed MRI and transcranial Doppler (TCD) within 12 month
본 연구에서는 한국교육개발원의 한국교육종단연구 7, 8차년도 데이터를 사용하여 대학교 영어 전공강의가 학생들 의 학업 자기효능감 및 영어 의사소통 자아개념에 미치는 효과를 분석하였다. 우선, 영어전공강의의 선택에 영향을 미치는 요인을 분석하였고, 이를 토대로 경향점수매칭(Propensity Score Matching) 방식을 적용하였다. 추가로, Rosenbaum Bounds와 Mantel-Haenszel Bounds 같은 민감도 분석(Sensitivity Analysis)을 실시하여 비관측 외부요인의 영향력을 확인하였다. 분석 결 과, 영어 전공강의 선택에 있어 전년도 영어강의 수강학점 및 수능 외국어영역 점수, 학업자아개념이 중요한 요인으로 작용 하였으며, 선택편의 조정 이후, 영어 전공강의가 관심 종속변수에 갖는 처치효과의 유의성은 상실되었다. 민감도 분석 결과, 영어 전공강의의 효과는 관찰되지 않은 외부변인의 영향력으로부터 강건하다고 나타났다. 일련의 결과를 바탕으로 대학에서
Objective: To translate the English Qualiveen questionnaire which was developed to measure the specific impact of urinary problems on the quality of life of patients with neurogenic bladder into Korean and validate it. Method: First, we made the Korean version Qualiveen questionnaire through translation and cross-cultural adaptation followed by the international guideline. This process consisted of 6 steps including translation, reconciliation, back translation into English and debriefing. And t