Yong-Sup Lee
Kyung Hee University · 医学
研究室紹介
Professor Yong-Sup Lee's research lab specializes in natural product chemistry and medicinal chemistry, with a focus on the isolation, structural elucidation, and synthesis of bioactive natural compounds—particularly lignans and kojic acid derivatives—targeting cancer chemotherapy, antioxidant, antimicrobial, and anti-inflammatory activities. The lab also investigates enzyme inhibitors, such as tyrosinase and COX-2, through rational drug design and synthetic methodology development, including asymmetric synthesis and reactive intermediates like N-acyliminium ions. Their work bridges organic synthesis with biological evaluation to develop novel therapeutic agents with improved selectivity and reduced side effects.
Research Overview
Research Output Trend
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Selected Papers
15Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C6-C3) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammat
Kojic acid derivative 2 was synthesized by joining two pyrone rings through an ethylene linkage by Horner-Emmons reaction of phosphonate 6 with aldehyde 7. The intermediates 6 and 7 were derived from kojic acid. The tyrosinase inhibitory activity of 2 was about 8 times more potent (IC(50) = 3.63 microM) than that of kojic acid (IC(50) = 30.61 microM). Compound 2 also exhibited potent melanin synthesis inhibitory activity (19.53% inhibition at 5 mug) indicating that the connection of two pyrone r
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric Synthesis of Both Enantiomers of Pyrrolidinoisoquinoline Derivatives from L-Malic Acid and L-Tartaric AcidYong Sup Lee, Dong Wook Kang, Sook Ja Lee, and Hokoon ParkCite this: J. Org. Chem. 1995, 60, 22, 7149–7152Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/jo00127a019https://doi.org/10.1021/jo00127a019research-articleACS PublicationsRe
The traditional nonsteroidal anti-inflammatory drugs (NSAIDs) exert their effect by inhibition of cyclooxygenase-1 (COX-1) as well as COX-2 enzymes. As COX-1 is responsible for maintaining normal biological functions, the nonselective inhibition of these enzymes caused side effects including gastrointestinal (GI) problems. Recently developed selective COX-2 inhibitors could reduce these adverse effects, but the evidence of cardiovascular side effects including an increased risk of myocardial inf
N-acyliminium ions are reactive intermediates that can act as electron-deficient electrophiles toward weak or soft nucleophiles, thereby providing useful methods for both intermolecular- and intramolecular carbon-carbon and carbon-heteroatom bond formation. Nucleophilic additions to N-acyliminium ions constitute an important method for providing α-functionalized amino compounds and many other biologically active nitrogen-containing heterocycles. The development of efficient catalytic asymmetric