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Yongseok Sim

Sungkyunkwan University · 医学

研究室紹介

Professor Yongseok Sim's research lab specializes in artificial intelligence applications in medical imaging and clinical decision support, with a focus on deep learning, radiomics, and generative models for diagnostic enhancement. The lab develops AI-driven tools to improve the detection of diseases such as lung cancer, breast cancer, and Alzheimer’s disease through advanced image analysis and synthetic data generation. Key research directions include interpretable AI, including reasoning-aware frameworks using large language models, and the integration of AI with clinical workflows to address data scarcity and improve diagnostic accuracy.

medical imagingdeep learningradiomicsgenerative modelsclinical decision support

Research Overview

Papers
34
Total Citations
474
Papers (5y)
29
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
29total
2022
2023
2024
2025
2026
Citations per year (5y)
189total
20222023202420252026

Selected Papers

15
1
Article|241 citations·2019
Deep Convolutional Neural Network–based Software Improves Radiologist Detection of Malignant Lung Nodules on Chest Radiographs
Yongsik Sim, Myung Jin Chung, Elmar Kotter, Sehyo Yune, Myeongchan Kim, Synho Do, Kyunghwa Han, Hanmyoung Kim, Seungwook Yang, Dong-Jae Lee, Byoung Wook Choi
SJR Q1RadiologyOA

Background Multicenter studies are required to validate the added benefit of using deep convolutional neural network (DCNN) software for detecting malignant pulmonary nodules on chest radiographs. Purpose To compare the performance of radiologists in detecting malignant pulmonary nodules on chest radiographs when assisted by deep learning-based DCNN software with that of radiologists or DCNN software alone in a multicenter setting. Materials and Methods Investigators at four medical centers retr

Pulmonary and Respiratory MedicineMedicine
2
Article|39 citations·2024
Large Language Models Are Clinical Reasoners: Reasoning-Aware Diagnosis Framework with Prompt-Generated Rationales
Taeyoon Kwon, Kai Tzu-iunn Ong, Dong-Jin Kang, Seungjun Moon, Jeong Ryong Lee, Dosik Hwang, Beomseok Sohn, Yongsik Sim, Dong Ha Lee, Jinyoung Yeo
Proceedings of the AAAI Conference on Artificial IntelligenceOA

Machine reasoning has made great progress in recent years owing to large language models (LLMs). In the clinical domain, however, most NLP-driven projects mainly focus on clinical classification or reading comprehension, and under-explore clinical reasoning for disease diagnosis due to the expensive rationale annotation with clinicians. In this work, we present a "reasoning-aware" diagnosis framework that rationalizes the diagnostic process via prompt-based learning in a time- and labor-efficien

Artificial IntelligenceComputer Science
3
Article|28 citations·2024
Radiomics using non-contrast CT to predict hemorrhagic transformation risk in stroke patients undergoing revascularization
JoonNyung Heo, Yongsik Sim, Byung Moon Kim, Dong Joon Kim, Young Dae Kim, Hyo Suk Nam, Yoon Seong Choi, Seung‐Koo Lee, Eung Yeop Kim, Beomseok Sohn
SJR Q1European Radiology
Radiology, Nuclear Medicine and ImagingMedicine
4
Article|25 citations·2020
Predictive performance of ultrasonography-based radiomics for axillary lymph node metastasis in the preoperative evaluation of breast cancer
Si Eun Lee, Yongsik Sim, Sung‐Won Kim, Eun‐Kyung Kim
SJR Q1ULTRASONOGRAPHYOA

A radiomics model based on the US features of primary breast cancers showed additional value when combined with a clinicopathologic model to predict axillary lymph node metastasis.

Radiology, Nuclear Medicine and ImagingMedicine
5
Article|17 citations·2024
Latent diffusion model-based MRI superresolution enhances mild cognitive impairment prognostication and Alzheimer's disease classification
Dan Yoon, Youho Myong, Young Gyun Kim, Yongsik Sim, Minwoo Cho, Byung‐Mo Oh, Sungwan Kim
SJR Q1NeuroImageOA

The diffusion model-based MRI SR enhances the resolution of brain MR images, significantly improving diagnostic and prognostic accuracy for AD and MCI. Superresolved 3T* images closely matched actual 3T MRIs in quality and volumetric accuracy, and notably improved the prediction performance of conversion from MCI to AD.

Radiology, Nuclear Medicine and ImagingMedicine
6
Article|17 citations·2020
A Radiomics Approach for the Classification of Fibroepithelial Lesions on Breast Ultrasonography
Yongsik Sim, Si Eun Lee, Eun‐Kyung Kim, Sung‐Won Kim
SJR Q1Ultrasound in Medicine & BiologyOA
Radiology, Nuclear Medicine and ImagingMedicine
7
Article|16 citations·2023
Evaluating diagnostic content of AI-generated chest radiography: A multi-center visual Turing test
Youho Myong, Dan Yoon, Byeong Soo Kim, Young Gyun Kim, Yongsik Sim, Suji Lee, Jiyoung Yoon, Minwoo Cho, Sungwan Kim
SJR Q1PLoS ONEOA

BACKGROUND: Accurate interpretation of chest radiographs requires years of medical training, and many countries face a shortage of medical professionals to meet such requirements. Recent advancements in artificial intelligence (AI) have aided diagnoses; however, their performance is often limited due to data imbalance. The aim of this study was to augment imbalanced medical data using generative adversarial networks (GANs) and evaluate the clinical quality of the generated images via a multi-cen

Radiology, Nuclear Medicine and ImagingMedicine
8
Article|13 citations·2022
A deep learning algorithm to quantify AVF stenosis and predict 6-month primary patency: a pilot study
Jae Hyon Park, Jongjin Yoon, Insun Park, Yongsik Sim, Soo‐Jin Kim, Jong Yun Won, Kichang Han
SJR Q1Clinical Kidney JournalOA

Background: A deep convolutional neural network (DCNN) model that predicts the degree of arteriovenous fistula (AVF) stenosis and 6-month primary patency (PP) based on AVF shunt sounds was developed, and was compared with various machine learning (ML) models trained on patients' clinical data. Methods: Forty dysfunctional AVF patients were recruited prospectively, and AVF shunt sounds were recorded before and after percutaneous transluminal angioplasty using a wireless stethoscope. The audio fil

Emergency Medical ServicesHealth Professions
9
Article|12 citations·2022
Feasibility of Deep Learning-Based Analysis of Auscultation for Screening Significant Stenosis of Native Arteriovenous Fistula for Hemodialysis Requiring Angioplasty
Jae Hyon Park, Insun Park, Kichang Han, Jongjin Yoon, Yongsik Sim, Soo Jin Kim, Jong Yun Won, Shina Lee, Joon Ho Kwon, Sungmo Moon, Gyoung Min Kim, Man Deuk Kim
SJR Q1Korean Journal of RadiologyOA

Mel spectrogram-based DCNN models, particularly ResNet50, successfully predicted the presence of significant AVF stenosis requiring PTA in this feasibility study and may potentially be used in AVF surveillance.

Pulmonary and Respiratory MedicineMedicine
10
Article|9 citations·2023
Multiparametric MRI–based radiomics model for predicting human papillomavirus status in oropharyngeal squamous cell carcinoma: optimization using oversampling and machine learning techniques
Yongsik Sim, Minjae Kim, Jinna Kim, Seung‐Koo Lee, Kyunghwa Han, Beomseok Sohn
SJR Q1European Radiology
Radiology, Nuclear Medicine and ImagingMedicine
11
Article|9 citations·2023
MRI‐Based Radiomics Approach for Differentiating Juvenile Myoclonic Epilepsy from Epilepsy with Generalized Tonic–Clonic Seizures Alone
Yongsik Sim, Seung‐Koo Lee, Min Kyung Chu, Won‐Joo Kim, Kyoung Heo, Kyung Min Kim, Beomseok Sohn
SJR Q1Journal of Magnetic Resonance ImagingOA

BACKGROUND: The clinical presentation of juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures alone (GTCA) is similar, and MRI scans are often perceptually normal in both conditions making them challenging to differentiate. PURPOSE: To develop and validate an MRI-based radiomics model to accurately diagnose JME and GTCA, as well as to classify prognostic groups. STUDY TYPE: Retrospective. POPULATION: 164 patients (127 with JME and 37 with GTCA) patients (age 24.0

Psychiatry and Mental healthMedicine
12
Article|8 citations·2024
Revisiting gliomatosis cerebri in adult-type diffuse gliomas: a comprehensive imaging, genomic and clinical analysis
Ilah Shin, Yae Won Park, Yongsik Sim, Seo Hee Choi, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung‐Koo Lee, Rajan Jain
SJR Q1Acta Neuropathologica CommunicationsOA

Although gliomatosis cerebri (GC) has been removed as an independent tumor type from the WHO classification, its extensive infiltrative pattern may harbor a unique biological behavior. However, the clinical implication of GC in the context of the 2021 WHO classification is yet to be unveiled. This study investigated the incidence, clinicopathologic and imaging correlations, and prognostic implications of GC in adult-type diffuse glioma patients. Retrospective chart and imaging review of 1,211 ad

GeneticsMedicine
13
Article|7 citations·2024
Revisiting prognostic factors of gliomatosis cerebri in adult-type diffuse gliomas
Ilah Shin, Yongsik Sim, Seo Hee Choi, Yae Won Park, Narae Lee, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung‐Koo Lee
SJR Q1Journal of Neuro-Oncology
GeneticsMedicine
14
Article|6 citations·2024
Clinical, qualitative imaging biomarkers, and tumor oxygenation imaging biomarkers for differentiation of midline-located IDH wild-type glioblastomas and H3 K27-altered diffuse midline gliomas in adults
Yongsik Sim, Seo Hee Choi, Narae Lee, Yae Won Park, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung‐Koo Lee
SJR Q1European Journal of Radiology
GeneticsMedicine
15
Preprint|5 citations·2023
Large Language Models are Clinical Reasoners: Reasoning-Aware Diagnosis Framework with Prompt-Generated Rationales
Taeyoon Kwon, Kai Tzu-iunn Ong, Dong-Jin Kang, Seungjun Moon, Jeong Ryong Lee, Dosik Hwang, Yongsik Sim, Beomseok Sohn, Dong Ha Lee, Jinyoung Yeo
arXiv (Cornell University)OA

Machine reasoning has made great progress in recent years owing to large language models (LLMs). In the clinical domain, however, most NLP-driven projects mainly focus on clinical classification or reading comprehension, and under-explore clinical reasoning for disease diagnosis due to the expensive rationale annotation with clinicians. In this work, we present a "reasoning-aware" diagnosis framework that rationalizes the diagnostic process via prompt-based learning in a time- and labor-efficien

Artificial IntelligenceComputer Science

Research Areas

Radiology, Nuclear Medicine and ImagingGeneticsArtificial IntelligencePulmonary and Respiratory MedicinePsychiatry and Mental healthNeurology

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