Yoo Jin Jang
Korea University · 医学
研究室紹介
Professor Yoo Jin Jang's research lab focuses on regenerative medicine and stem cell biology, with a strong emphasis on understanding and harnessing the potential of pluripotent and mesenchymal stem cells for tissue repair and disease modeling. The lab develops advanced in vitro differentiation protocols to generate highly functional, homogeneous hepatocyte-like cells and trophoblast stem-like cells, aiming to improve disease modeling and drug toxicity screening. Additionally, the lab investigates the paracrine mechanisms of mesenchymal stem cells, particularly their secretome, in treating fibrotic diseases such as liver fibrosis. The lab also explores psychosocial factors in adolescent mental health, examining the interplay between grit, attention problems, aggression, and smartphone dependency through large-scale survey data analysis.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The placenta is a transient but important multifunctional organ crucial for healthy pregnancy for both mother and fetus. Nevertheless, limited access to human placenta samples and the paucity of a proper in vitro model system have hampered our understanding of the mechanisms underlying early human placental development and placenta-associated pregnancy complications. To overcome these constraints, we established a simple procedure with a short-term treatment of bone morphogenetic protein 4 (BMP4
본 연구는 청소년의 그릿, 주의집중 문제, 공격성, 휴대전화 의존도의 구조적 관계를 알아보고자 하였다. 이를 위해 한국아동청소년패널조사2018(KCYPS 2018) 중1패널 2차년도 자료(2,203명)를 활용하여, 매개, 조절, 조절된 매개효과를 순차적으로 분석하였다. 분석 결과, 첫째, 그릿은 주의집중 문제와 공격성에 부적으로 유의미한 영향을 미치고 주의집중 문제는 공격성에 정적으로 유의미한 영향을 미치는 것으로 나타났다. 둘째, 그릿이 주의집중 문제를 매개하여 공격성에 미치는 매개효과가 유의하게 나타나 그릿이 높을수록 주의집중 문제를 감소시켰으며 이는 공격성 감소로 이어졌다. 셋째, 휴대전화 의존도는 그릿이 공격성에 미치는 영향과 주의집중 문제가 공격성에 미치는 영향을 각각 유의하게 조절하였다. 넷째, 그릿이 주의집중 문제를 매개하여 공격성에 영향을 미치는 관계에서 휴대전화 의존도의 조절된 매개효과가 유의함을 확인하였다. 이를 통해 휴대전화 의존도의 공격성에 대한 부정적 영향을
Highly homogeneous and functional stem cell-derived hepatocyte-like cells (HLCs) are considered a promising option in the cell-based therapy of liver disease and the development of effective in vitro toxicity screening tools. However, the purity of cells and expression and/or activity of drug metabolizing enzymes in stem cell-derived HLCs are usually too low to be useful for clinical or in vitro applications. Here, we describe a highly optimized hepatic differentiation protocol, which produces >
원예치료 연구논문의 원예치료 효과 분석을 위하여 1985년부터 2009년 2월까지 총 377편의 국내･외 원예치료 관련 연구 논문(국내 학위논문 196, 국내 학술지 논문 113, 국외 학위논문 5, 국외 학술지 논문 63) 중 메타분석이 가능한 108편의 논문을 대상으로 메타분석을 수행한 결과, 전체적인 원예치료의 효과크기(Effect size)는 0.71로 나타나 효과가 큼을 알 수 있었다. 대상자의 유형과 연령, 인원수 간의 효과분석 결과, 아동을 대상으로 실시한 연구에 있어서 가장 효과가 컸으며 대상자의 유형에 있어서는 일반인에 비하여 정신지체아동, 치매 노인에 있어서 효과가 높음을 알 수 있었다. 연구대상자수에 있어서는 5명 이하로 구성된 소그룹에서 효과가 컸으며 연구자의 전공영역에 있어서는 원예관련학과에서 수행한 원예치료 프로그램의 효과가 타전공 영역에서 보다 큰 것을 알 수 있었다. 원예치료 프로그램 관련 변인에 있어서의 효과분석에서는, 화훼장식을 이용한 프로그램이 효과
The beneficial paracrine roles of mesenchymal stem cells (MSCs) in tissue repair have potential in therapeutic strategies against various diseases. However, the key therapeutic factors secreted from MSCs and their exact molecular mechanisms of action remain unclear. In this study, the cell-free secretome of umbilical cord-derived MSCs showed significant anti-fibrotic activity in the mouse models of liver fibrosis. The involved action mechanism was the regulation of hepatic stellate cell activati
BACKGROUND: Poststernotomy mediastinitis is a rare, but life-threatening complication, thus early diagnosis and proper management is essential for poststernotomy mediastinitis. The main treatment for mediastinitis is aggressive debridement. Several options exist for reconstruction of defects after debridement. The efficacy of immediate debridement and reconstruction with a pectoralis major muscle flap designed for the defect immediately after the diagnosis of poststernotomy mediastinitis is demo
Our findings suggest that both PC-PTSD-K and SIPS-K have good psychometric properties with high validity and reliability for detecting PTSD symptoms in elderly Korean veterans. However, further research will be necessary to increase our understanding of PTSD characteristics in diverse groups with different types of trauma.
BACKGROUND: This study aimed to investigate the difference between ultrasonographic findings of normal skin and those of re-epithelialized skin after partial-thickness burns and to evaluate the relationship between these findings and clinical outcomes. METHODS: This study retrospectively analysed the ultrasound images of re-epithelialized skin after partial-thickness burns and contralateral normal skin from January 2016 to December 2016. A total of 155 lesions from 148 patients were analysed wit
The beneficial paracrine roles of mesenchymal stem cells (MSCs) in tissue repair have potential in therapeutic strategies against various diseases. However, the key therapeutic factors secreted from MSCs and their exact molecular mechanisms of action remain unclear. In this study, the cell-free secretome of umbilical cord-derived MSCs showed significant anti-fibrotic activity in the mouse models of liver fibrosis. The involved action mechanism was the regulation of hepatic stellate cell activati
ABSTRACT The placenta is a transient but important multifunctional organ crucial for healthy pregnancy for both mother and fetus. Nevertheless, limited access to human placenta samples and the paucity of a proper in vitro model system has hampered our understanding of the mechanisms underlying early human placental development and placenta-associated pregnancy complications. To overcome these constraints, we established a simple procedure with a short-term treatment of bone morphogenetic protein
본 연구는 여자 대학생의 이미지 기반 SNS 이용과 이상섭식행동의 관계를 살펴보고, 이미지 기반 SNS 이용과 이상섭식행동의 관계에서 사회지향성의 조절효과를 확인하고자 하였다. 이를 위해 이미지 기반 SNS(인스타그램)를 이용하는 여자 대학생 223명을 대상으로 한국판 섭식태도검사-26, SNS 몰입 척도, SNS 자기체시 척도, 성격 양식 질문지(PSI-Ⅱ)척도를 사용하여 온라인 설문을 실시하였다. 수집된 자료는 SPSS 통계 프로그램을 사용하여 분석하였다. 본 연구의 결과는 다음과 같다. 첫째. 이미지 기반 SNS의 이용은 이상섭식행동에 정적으로 유의한 영향을 미치는 것으로 나타났다. 둘째. 이미지 기반 SNS와 이상섭식행동의 관계에서 사회지향성의 조절효과를 살펴본 결과. 상호작용 효과가 유의하게 확인되었다. 즉, 여자대학생의 사회지향성 수준이 높을수록 이미지 기반 SNS 이용이 이상섭식행동에 미치는 영향력이 증가하였다. 마지막으로, 본 연구 결과의 시사점, 한계점 및 후속연구에
This study was conducted to investigate the effects and influences of horticultural activities program which has the educational element of creativity and personality applied to the primary school aged children. To confirm the effects of the Horticultural Activities Program (HAP), 31 children aged 8-10 years from J child community center in S city was set to test. 16 children were chosen for the experimental group, and 15 children who were not participated for the HAP were selected as the contro
In this study, 10 students who participated in the horticultural therapy program and 10 students of control group were selected and surveyed in the alternative school before and after the program. The study period was 2013.9.2~2013.11.26 and the horticultural therapy program was carried out once a week. The SPSS WIN 18.0 program was employed to analyze the collected data, and Wilcoxon singed rank test was utilized to compare their pre and post test collective averages. Before the horticultural t