Young-ho Kim

Tuberculosis (TB) is a still prevalent and important disease entity in Korea. TB can involve any part of the gastrointestinal tract, and intestinal TB is an important disease of extra-pulmonary TB. The diagnosis of intestinal TB remains a challenge because the signs and symptoms are nonspecific. It should be differentiated from the inflammatory bowel diseases and malignancies, especially Crohn’s disease. The diagnosis of intestinal TB should be based on careful clinical evaluation, such as extra

이 논문은 위계선형모형(Hierarchical Linear Model, HLM)을 적용해 서 조직의 구조적 특성이 공무원의 직무만족에 미치는 영향을 분석한 것이다. 그동안 직무만족을 포함한 개인의 태도나 행태를 설명하기 위한 가장 일반화된 접근방법은 회귀방정식이나 구조방정식(Structural Equation Model)을 이용하는 것이었다. 이 경우 가장 문제가 되는 것은 분석의 차원이 다른 경우 이것을 모델에 담지 못한다는 점이다. 그런데 조직에서 개인의 태도나 행태는 개인 수준의 특성뿐만 아니라 그보다 상위 차원의 부서나 조직 차원에 의해서도 영향을 받는다. 이런 사례 중의 하나가 조직차원의 구조적 특성이 개인의 직무만족에 영향을 미치는 경우라 할 수 있으며 이런 경우 HLM이 기존의 방법론적 한계를 극복할 수 있음을 제시하고자 한다. 분석결과 조직의 구조적 특성 중에서 공식성만이 직무만족에 양(+)의 영향관계를 보여주었다. 이 결과는 집단차원의 회귀분석과 구조방정식을 이용한

Panton-Valentine leukocidin (PVL)-positive USA300 clone has been the most successful community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clone spreading in North America. In contrast, PVL-negative ST72-CA-MRSA has been predominant in Korea, and there has been no report of infections by the USA300 strain except only one case report of perianal infection. Here, we describe the first case of pneumonia caused by the USA300 strain following pandemic influenza A (H1N1) in Korea.

Purpose: The present study was aimed to determine whether endoscopist specialty is associated with high-quality endoscopy. Materials and Methods: We prospectively collected endoscopy quality related data based on the Endoscopy Quality Rating Scale (EQRS) of 277 endoscopy units in a hospital setting from the National Cancer Screening Program of Korea in 2009. Gastroenterology medical professors (n=154) from university hospitals visited each endoscopy unit and graded the unit according to the EQRS

Purpose: Infliximab is currently used for the treatment of active Crohn’s disease (CD). We aimed to assess the efficacy and safety of infliximab therapy and to determine the predictors of response in Korean patients with CD. Materials and Methods: A total of 317 patients who received at least one infliximab infusion for active luminal CD (n=198) and fistulizing CD (n=86) or both (n=33) were reviewed retrospectively in 29 Korean referral centers. Clinical outcomes of induction and maintenance the

Orthodontic force causes gradual compression of the periodontal ligament tissues, which leads to local hypoxia in the compression side of the tissues. In this study, we investigated whether antioxidants exert a regulatory effect on two factors: the expression of pro-inflammatory cytokines in human periodontal ligament fibroblasts (PDLFs)that were exposed to mechanical compression and hypoxia and the rate of orthodontic tooth movement in rats. Exposure of PDLFs to mechanical compression (0.5-3.0g

Background/Aims: Pediatric inflammatory bowel disease (IBD) has been increasing worldwide. The characteristics of pediatric-onset IBD have mainly been reported in Western countries. We investigated the clinical characteristics of pediatric IBD in Korea and compared these with the data from the 5-year European multicenter study of children with new-onset IBD (EUROKIDS registry). Methods: Children who were diagnosed with IBD between July 1987 and January 2012 were investigated at five Korean unive

Background/Aims: CpG island methylator phenotype (CIMP)- high colorectal cancers (CRCs) have distinct clinicopathological features from their CIMP-low/negative CRC counterparts. However, controversy exists regarding the prognosis of CRC according to the CIMP status. Therefore, this study examined the prognosis of Korean patients with colon cancer according to the CIMP status. Methods: Among a previous cohort population with CRC, a total of 154 patients with colon cancer who had available tissue

목적: 1980년대 중반부터 우리나라의 궤양성 대장염 환자수는 꾸준히 증가해 오고 있다. 궤양성 대장염에 이환된지 10여 년이 지나면 대장암의 발생 위험도가 증가한다는 서구 보고에 비추어 볼 때, 우리나라에서도 궤양성 대장염 연관 대장암의 발생이 본격화되는 시점에 도달했다고 예상한다. 이번 연구에서는 우리나라 궤양성 대장염 연관 대장암의 현황을 알아보고, 향후 추세를 전망하고자 하였다. 대상 및 방법: 대한장연구학회에서는 전국의 주요 대학병원을 대상으로 1993년부터 2003년 사이에 발생한 총 11예의 궤양성 대장염 연관 대장암 환자 증례를 수집하여 기술 분석을 시도하고 총체 유병률을 추정하였다. 결과: 궤양성 대장염 연관 대장암의 진단 평균연령은 49.3세였고, 평균 유병 기간은 12.5년이었다. 전대장염에서 속발된 대장암이 91%, 우측대장암은 28%였으며, 다발 종양은 18.2%였다. 암이 진행된 상태에서 진단된 경우가 많아 진단 시 병기 Dukes’ D가 36.3%였다. 정

Background/Aims: Studies concerning the efficacy and safety of single-balloon enteroscopy (SBE) compared with that of double-balloon enteroscopy (DBE) often appear to be conflicting. However, previous studies were performed by endoscopists who were less experienced in SBE compared with DBE. Methods: We performed a retrospective analysis of SBE and DBE data performed by a single enteroscopist, with expertise in SBE, using a prospective balloon-assisted enteroscopy registry from 2013 to 2015. Furt

Background/Aims: Seasonal variation may influence the development and exacerbation of inflammatory bowel disease (IBD). However, most epidemiologic studies on this topic have been conducted in Western countries. The purpose of this study was to determine whether birth dates and symptom flares follow a seasonal pattern in Korean patients with IBD. Methods: Patients with a diagnosis of IBD established between January 2003 and December 2010 were investigated at six university hospitals in Korea. Th

Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) with uncertain etiopathogenesis. CD caninvolve any site of gastrointestinal tract from the mouth to anus and is associated with serious complications suchas bowel strictures, perforations, and fistula formation. The incidence and prevalence rates of CD in Korea are stilllower than those of Western countries, but have been rapidly increasing during the past decades. Although thereare no definitive curative modalities for CD, vario

Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by a relapsing and remitting course. The quality of life can decrease significantly during exacerbations of the disease. The incidence and prevalence ofUC in Korea are still lower than those of Western countries, but have been rapidly increasing during the past decades. Various medical and surgical therapies are currently used for the management of UC. However, many challengingissues exist and sometimes these lead to

Background/Aims: Several recent studies have reported that the early use of infliximab (IFX) improves the prognosis of Crohn’s disease (CD). However, no data are available from Asian populations, as the forementioned studies have all been conducted in Western countries. The aim of the current study was to evaluate the impact of early use of IFX on the prognosis of Korean patients with CD. Methods: Patients with a diagnosis of CD established between July 1987 and January 2012 were investigated in

Background/Aims: Microscopic colitis (MC) encompasses collagenous and lymphocytic colitis and is characterized by chronic diarrhea. In cases of MC, colonic mucosae are macroscopically normal, and diagnostic histopathological features are observed only upon microscopic examination. We designed a prospective multicenter study to determine the clinical features, pathological distribution in the colon and prevalence of MC in Korea. Methods: We prospectively enrolled patients having watery diarrhea n