Young Yul Lee
Hanyang University · 医学
研究室紹介
Professor Young Yul Lee's research lab specializes in hematologic malignancies and lymphoproliferative disorders, with a focus on rare and complex presentations of lymphomas, leukemias, and paraneoplastic syndromes. The lab investigates the pathogenesis, clinical associations, and prognostic markers of conditions such as peripheral T-cell lymphoma, eosinophilic fasciitis, extramedullary plasmacytoma, and post-transplant lymphoproliferative disorders. Key research directions include the role of angiogenic factors like VEGF-D and VEGFR-3 in gastric cancer progression and the clinical implications of overlapping inflammatory and lymphoproliferative syndromes such as Kawasaki disease with hemophagocytic lymphohistiocytosis.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Although eosinophilic fasciitis (EF) may precede hematologic malignancy or Hodgkin's disease, association with peripheral T-cell lymphoma (PTCL) is extremely rare. Only four cases of EF preceding or concomitant PTCL have been reported in the world literature. We experienced the first Korean case of EF complicated by the later relapse of peripheral T-cell lymphoma. A 63-year-old Korean male has been followed at our outpatient clinic periodically after treatment for stage IV PTCL. He had been in c
Lymph node metastasis is an important prognostic factor in gastric cancer. Vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that activates VEGF receptor (VEGFR)-3, a receptor expressed in the lymphatic endothelium. We investigated the clinical value of VEGF-D expression and VEGFR-3 positive vessel density in gastric carcinoma with regard to lymphangiogenesis. Immunohistochemical staining was used to determine the expression of VEGF-D and VEGFR- 3 in specimens from
Extramedullary plasmacytoma may originate in any organ, either as a primary tumor or as a facet of systemic multiple myeloma. These solid lesions most commonly affect the upper respiratory tract, gastrointestinal and urogenital tract, skin, and lung. Primary plasmacytoma of the lymph node is a rare hematologic neoplasm, which usually manifests as an enlargement of the cervical lymph nodes with no evidence of any other plasma cell dyscrasia. A 56-year-old man was admitted, due to the presence of
Chronic myelogenous leukemia (CML) is a malignant clonal disorder of hemopoietic stem cells characterized by abnormal proliferation and accumulation of immature granulocyte. Leukostasis is one of the complications of CML and is characterized by partial or total occlusion of microcirculation by aggregation of leukemic cells and thrombi leading to respiratory, ophthalmic or neurologic symptoms. We experienced a rare case of avascular necrosis of the femoral head as the initial presentation of chro
KD와 HLH는 초기 증상은 비슷하나, KD는 예후가 좋은 것에 반해 HLH는 불량한 예후를 보일 수 있다. KD는 자연 치유 과정을 거치는 데 반해 HLH는 치명적일 수 있으므로, 두 질환을 감별하고 가능한 빨리 치료를 시작하는 것이 중요하다. KD에서 속발한 HLH는 사례가 매우 적어 예후 예측이 힘들며 초치료를 결정하기가 힘드나, 일반적인 KD치료인 대증적 치료보다는 적극적인 치료를 하는 것이 환자의 좋은 예후를 기대 할 수 있을 것으로 생각된다. 저자들은 21세 성인 여성에서 KD에 HLH가 속발 한 것으로 진단되어 고용량 스테로이드 치료를 받고 완전히 회복된 1예를 보고하는 바이다.
T세포 거대과립림프구성백혈병은 CD3+ 세포독성 T세포의 클론증식질환으로, 일반적으로 CD3+CD4- CD8+CD16+CD56-CD57+ 세포 표식자를 발현하며, TCR 수용체 유전자 재배열이 발생한다. 대부분의 경우 무활동성의 임상 양상을 보이지만, CD3+CD56+로 세포표식자가 발현되는 경우는 공격적인 변이형에 해당되며, 이는 매우 드문 것으로 알려져 있다. 이에 저자 등은 국내에서 보고된 적이 없는 T세포 거대과립림프구성백혈병을 경험하였고, 진단 시에는 무활동성으로 특별한 증상 및 징후가 없어 특별한 치료 없이 경과 관찰 하던 중, 2년 후에 갑작스런 임상양상의 악화를 보이면서 CD56+ 세포 표식자 발현을 보였던 1예에 대해서 임상적 의미에 대한 고찰과 함께 보고하는 바이다.
Post-transplant lymphoproliferative disorders (PTLD) have been recognized as a complication of immunosuppression and occur with a reported incidence of 1 to 8% of recipients receiving solid organ transplantation. PTLD are classified into two major categories, polymorphic and monomorphic PTLD. The majority of the monomorphic PTLD cases are non-Hodgkin's lymphoma of B-cell origin. Hodgkin's disease is not part of the typical spectrum of PTLD; however, it has been rarely reported. We describe a cas
Acute respiratory failure with diffuse pulmonary infiltration was occurred in a patient with malignant lymphoma 1month after the 8th CHOP chemotherapy. The ground glass and consolidation appearances on chest C-T in this immunodeficient patient could be presented in many clinical situations such as pneumonia by opportunistic infections(fungal, parasites, viral, and usual bacterial pathogens), anti-tumor drug's pulmonary toxicity and tumor invasion. And the other diseases of acute interstitial pne
Essential thrombocythemia (ET) is a chronic myeloproliferative disorder with a prolonged clinical course. Since this disorder is considered to be at increased risk of thromboembolism, therapy is mainly focused on the decreased risk of thrombohemorrhagic events by use of cytotoxic agents. Anagrelide is a phosphodiesterase III inhibitor which is utilized in the treatment of ET for the reduction of platelets. However, patients treated with anagrelide might experience cardiovascular adverse effects