Yujin Lim
Kyung Hee University · 医学
研究室紹介
Professor Yujin Lim's research lab specializes in translational oncology and cancer therapeutics, with a focus on improving outcomes in head and neck, breast, and gastrointestinal cancers through radiation oncology, biomarker discovery, and novel therapeutic strategies. The lab investigates prognostic factors, treatment response, and mechanisms of resistance in locally advanced and early-stage cancers, integrating clinical data with molecular and preclinical models. Key research directions include radiosensitization, the role of growth factors like EGF in tumor response, and the development of predictive nomograms for metastatic risk and survival. The lab also explores natural compounds with anti-cancer and neuroprotective properties, such as those found in kiwifruits, for potential chemopreventive applications.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15PURPOSE: This study evaluates the long-term results of definitive radiotherapy (RT) for early glottic cancer. Clinical and treatment factors related to local control and patterns of failure are analyzed. MATERIALS AND METHODS: We retrospectively reviewed 222 patients with T1-2N0 squamous cell carcinoma of the glottic larynx treated with definitive RT from 1981 to 2010. None of the patients received elective nodal RT or combined chemotherapy. The median total RT dose was 66 Gy. The daily fraction
Five domestic kiwifruit varieties, Bidan (BD),Chiak (CA), Haegeum (HG), Haehyang (HH), and Mansoo(MS), in Korea and two imported varieties, Hayward (HW)and Hort16A (HT), from New Zealand were evaluated mainactive component groups in the fruit extracts involved inantioxidant and anti-dementia activities. HW, HT, and HHexhibited higher soluble solid content. BD, HG, and HHcontained high total phenolics (TP), whereas two importedkiwifruits and green kiwifruits (MS and CA) had low TPcontent. BD show
BACKGROUND: Despite the widespread use of neoadjuvant chemoradiotherapy, there is no prognostic surrogate marker established in locally advanced rectal cancer. OBJECTIVE: This study evaluated the role of neoadjuvant rectal score as a prognostic factor to stratify individual-level risks of survival and tumor recurrence. DESIGN: This is a retrospective study. SETTINGS: This study was conducted at the Seoul National University Hospital. PATIENTS: A total of 397 patients who underwent chemoradiother
This study evaluated the prognostic impact of ACT in patients who achieved a pathological complete response (pCR). Articles published from January 1990 to September 2018 were searched in EMBASE, PubMed, Ovid, Web of Science, and Cochrane Library. Hazard ratios (HRs) and 95% confidence intervals (CIs) of overall survival (OS) were extracted. Thirteen observational studies were included. There were four National Cancer Database studies with overlapping study periods, thus individual pooled analyse
PURPOSE: This study aimed to identify predictors for distant metastatic behavior and build a related prognostic nomogram in breast cancer. MATERIALS AND METHODS: A total of 1,181 patients with non-metastatic breast cancer between 2003 and 2011 were analyzed. To predict the probability of distant metastasis, a nomogram was constructed based on prognostic factors identified using a Cox proportional hazards model. RESULTS: The 7-year overall survival and 5-year post-progression survival of locoregi
PURPOSE: The purpose of this study was to evaluate whether an exogenous epidermal growth factor (EGF) could induce anti-tumor and radiosensitizing effects in vivo. MATERIALS AND METHODS: BALB/c-nu mice that were inoculated with A431 (human squamous cell carcinoma) cells in the right hind legs were divided into five groups: I (no treatment), II (EGF for 6 days), III (EGF for 20 days), IV (radiotherapy [RT]), and V (RT plus concomitant EGF). EGF was administered intraperitoneally (5 mg/kg) once a