Yun Ah Hwang

Objective: Improved molecular testing for common somatic mutations and the identification of mRNA and microRNA expression classifiers are promising approaches for the diagnosis of thyroid nodules. However, there is a need to improve the diagnostic accuracy of such tests for identifying thyroid cancer. Recent findings have revealed a crucial role of long non-coding RNAs (lncRNAs) in gene modulation. Thus, we aimed to evaluate the diagnostic value of selected lncRNAs from The Atlas of Noncoding RN

Objective: Non-alcoholic fatty liver disease (NAFLD) is characterized by growth hormone deficiency (GHd). We investigated the association between NAFLD and GHd in patients with nonfunctioning pituitary adenomas (NFPA). Design and methods: We recruited patients with NFPA who underwent transsphenoidal adenectomy between January 2005 and December 2018. Pituitary function was determined by the insulin tolerance test, thyroid hormone assay, and gonadal hormone levels. NAFLD was defined as a hepatic s

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disorder characterized by multiorgan endocrine tumors, primarily affecting the parathyroid glands, pituitary, and pancreas. Despite its clinical significance, the epidemiology and outcomes of clinically suspected MEN1 in Asian populations remain limited. This study aimed to investigate the prevalence, comorbidities, and mortality risk associated with clinically suspected MEN1 in South Korea. Methods: We conducted a retro

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

INTRODUCTIONWe recently developed a deep convolutional neural network algorithm (SEveRance Artificial intelligence program, SERA) using 13,560 ultrasound images of thyroid nodules labeled benign and malignant and this algorithm showed comparable diagnostic performance with experienced radiologists. We assessed whether the self-learning method similar to deep learning could be adapted for human learning as an ancillary approach to one-on-one education. METHODOLOGYTwenty-one internal medicine resi

A pyriform sinus tract/fistula is a rare clinical condition where remnants of the third or fourth pharyngeal pouches extend into the pyriform sinus, forming an internal tract. Common initial presentations of pyriform sinus tract/fistulas are cervical cystic masses in neonates or cervical infections in children but there have been a few reported cases of incidental detection of pyriform sinus tracts in adults. A 62-year-old man was referred from a local clinic for evaluation of a hypoechoic thyro

Abstract Objectives Improved molecular testing for common somatic mutations and identification of mRNA and microRNA expression classifiers have emerged as the most promising approaches for diagnosis of thyroid nodules. However, it is necessary to effectively increase diagnostic accuracy further. Currently, lncRNA research has moved to the forefront of human cancer research, as recent findings have revealed a crucial role of lncRNAs in gene modulation. We evaluated the diagnostic value of the sel

Abstract Disclosure: D. Kim: None. Y. Bao: None. M. Kang: None. Y. Cho: None. Y. Kim: None. Y. Hwang: None. C. Ku: None. E. Lee: None. Objectives: Over years, various approaches have been used to model human Graves’ disease in mice, including transfected fibroblasts, and plasmid or adenoviral immunizations with the extracellular A subunit of the human thyrotropin receptor (hTSHRa). However, these models require a lot of effort for multiple dosing over several months and the results are very hete

Abstract Aging plays a critical role in the progression of invasive neuroendocrine tumors (NETs) through mechanisms such as extracellular matrix remodeling, immune evasion, and cellular senescence. However, the influence of aging on pituitary neuroendocrine tumors (PitNETs) remains largely unexplored due to the absence of pituitary-specific aging studies. To address this gap, we investigated age-associated transcriptional changes in the normal pituitary as a foundation for understanding PitNET p

Abstract Disclosure: K. Kim: None. Y. Hwang: None. M. Yu: None. S. Moon: None. N. Hong: None. Y. Rhee: None. Multiple Endocrine Neoplasia Type 1 (MEN1) is one of the rarest endocrine disorders, with a scarcity of comprehensive epidemiological data globally. This deficiency in data is even more pronounced in Asian populations, where MEN1 remains an under-researched area. Therefore, our aim is to identity the prevalence, demographic characteristics, and patterns of comorbidities associated with ME

Abstract Disclosure: Y. Hwang: None. H. Lee: None. S. Ahn: None. E. Lee: None. C. Ku: None. S. Kim: None. Objective: We investigated the association between nonalcoholic fatty liver disease (NAFLD) and growth hormone deficiency (GHD) in patients with non-functioning pituitary adenoma (NFPA). Methods: Patients with NFPA who underwent transsphenoidal adenectomy between January 2005 and December 2018 were recruited. Pituitary function was determined by the insulin tolerance test, thyroid hormone as

Abstract Disclosure: K. Kim: None. Y. Hwang: None. M. Yu: None. S. Moon: None. N. Hong: None. Y. Rhee: None. Multiple Endocrine Neoplasia Type 1 (MEN1) is one of the rarest endocrine disorders, with a scarcity of comprehensive epidemiological data globally. This deficiency in data is even more pronounced in Asian populations, where MEN1 remains an under-researched area. Therefore, our aim is to identity the prevalence, demographic characteristics, and patterns of comorbidities associated with ME

Abstract Disclosure: D. Kim: None. Y. Hwang: None. S. Park: None. H. Jang: None. J. Rim: None. S. Lee: None. Y. Rhee: None. Background: The rapid advancement of clinical cancer drug development, particularly in immunotherapy, targeted therapies, antibody-based treatments, and personalized medicine, aims to improve efficacy and precision. However, the condition of cancer patients and their treatments can often impact endocrine function testing, complicating result interpretation.Clinical Cases: A