Yun-hee Jin
Yonsei University
研究室紹介
Professor Yun-hee Jin's research lab specializes in developing advanced in vitro disease modeling systems using microengineered platforms, with a focus on neural and skeletal muscle tissues. The lab investigates the dynamic crosstalk between different cell types—such as endothelial cells and neural stem cells—to understand and control stem cell behavior, including self-renewal and differentiation, for regenerative medicine applications. A key emphasis is on creating physiologically relevant 3D microenvironments that replicate the structural and mechanical cues of native tissues, enabling better modeling of disease mechanisms and drug responses. The lab also pioneers organ-on-a-chip technologies, integrating vascularization and multi-organ systems to enhance physiological relevance.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
2Control of neural stem cell (NSC) self-renewal and differentiationis of great importance to improve itstherapeutic efficacy in the treatment of neurodegenerative diseases. Neurosphere culture for NSCexpansion under undifferentiation condition determines the self-renewal capacity and differentiationpropensity of NSCs. In this study, we examined the effects of controlled crosstalk between endothelialcells (ECs) and NSC neurospheres on self-renewal, differentiation, and functions of NSCs. Cultures
Purpose: Conventional 2-dimensional cultures and animal models have limited ability to reproduce the structural complexity, dynamic mechanical cues, and sustained functionality of native skeletal muscle tissue. To overcome these limitations, skeletal muscle-on-a-chip platforms have been developed as advanced in vitro systems for studying muscle physiology, pathology, and regeneration. Current Concepts: These microengineered systems incorporate essential features of skeletal muscle, including 3-d