Yun Ju Kwon
Kyung Hee University · 医学
研究室紹介
Professor Yun Ju Kwon's research lab specializes in natural product discovery and drug development, with a focus on identifying bioactive compounds from microbial and plant sources for the treatment of infectious diseases and pathological conditions. The lab investigates enzyme inhibitors targeting essential bacterial pathways, such as enoyl-ACP reductase in drug-resistant pathogens like *Staphylococcus aureus*, *Streptococcus pneumoniae*, and *Mycobacterium tuberculosis*, as well as antifungal agents against fungal pathogens such as *Ascosphaera apis*. The research integrates natural product chemistry, microbiology, and biochemical assays to explore structure-activity relationships and synergistic effects of natural compounds. The lab also examines host-pathogen interactions and tissue-level pathophysiological changes, such as liver damage following thermal injury, to understand disease mechanisms and identify therapeutic targets.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
5In the continued search for inhibitors of enoyl-acyl carrier protein (ACP) reductase, we found that four acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761 potently inhibited bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis. Their structures were identified as panosialins A, B, wA, and wB by MS and NMR data. They showed stronger inhibition against S. aureus FabI and S. pneumoniae FabK with IC50 of 3-5 microM than M. t
In the continued search for inhibitors of enoyl-acyl carrier protein (ACP) reductase, we found that four acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761 potently inhibited bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis. Their structures were identified as panosialins A, B, wA, and wB by MS and NMR data. They showed stronger inhibition against S. aureus FabI and S. pneumoniae FabK with IC50 of 3-5 microM than M. t
Honey bees are important pollinators in agriculture, but are threatened by the pathogen Ascosphaera apis , which causes chalkbrood. Despite attempts to control this fungus using synthetic fungicides, none of them have been proven to be completely effective. Among 640 natural compounds that we tested, 4-hydroxyderricin (MIC=3.125, 6.25 mg/L after 24 h and 48 h growth, respectively) exhibited the strongest anti- Ascosphaera apis activity, followed by acetylshikonin (MIC=12.5 mg/L for 24 h and 48 h
Every major or extensive thermal skin injury is almost invariably accompanied by a secondary lesion of the liver parenchyme that can, as a rule, be found with certain clinico-laboratory abnormality and that was the reason why we focused our attention to the pathologic changes of liver parenchyme after thermal injury. An experimental study was performed in order to investigate the liver parenchymal changes that followed thermal injury in rat. The pathologic changes of the liver parenchyme were st