Yuri Seo
Yonsei University · 医学
研究室紹介
Professor Yuri Seo's research lab focuses on cellular and molecular mechanisms underlying disease progression, with a strong emphasis on cancer biology, mitochondrial dynamics, and ocular disorders. The lab investigates key regulatory proteins such as RPL17 and OPA1 in colorectal cancer and mitochondrial function, exploring both ribosomal and extra-ribosomal roles in tumorigenesis. Additionally, the lab examines pathological conditions in the eye, including dry eye syndrome and traumatic choroidal rupture, aiming to identify biomarkers and novel therapeutic interventions. Their work integrates molecular biology, cell proliferation assays, and clinical translational approaches to uncover disease mechanisms and potential treatments.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Cell proliferation represents one of the most fundamental processes in biological systems, thus the quantitative analysis of cell proliferation is important in many biological applications such as drug screening, production of biologics, and assessment of cytotoxicity. Conventional proliferation assays mainly quantify cell number based on a calibration curve of a homogeneous cell population, and therefore are not applicable for the analysis of cocultured cells. Moreover, these assays measure cel
Mitochondria are dynamic organelles that undergo fusion and fission in response to various physiological and stress stimuli, which play key roles in diverse mitochondrial functions such as energy metabolism, intracellular signaling, and apoptosis. OPA1, a mitochondrial dynamin-like GTPase, is responsible for the inner membrane fusion of mitochondria, and the function of OPA1 is regulated by proteolytic cleavage in response to various metabolic stresses. Growing evidences highlighted the importan
<b>Aims:</b> Ribosomal protein L17 (RPL17), a 60S subunit component, is up-regulated in colorectal cancer (CRC). However, its oncogenic role in CRC progression remains unexplored. Thus, we aimed to investigate the effect of RPL17 targeting on CRC <i>in vitro</i> and <i>in vivo</i> and whether RPL17 gained an extra-ribosomal function during CRC development. <b>Methods:</b> RPL17-specific siRNAs complexed with cationic lipids were transfected to CRC cells to silence target gene expression and then
<b>Propose</b>: We aimed to investigate the prevalence and risk factors of dry eye syndrome (DES) among a population-based cohort study.<b>Methods</b>: This cross-sectional study was conducted on 475 subjects (184 men and 291 women) enrolled in the Study Group for Environmental Eye Disease at July 2013. Using the ocular surface disease index (OSDI), we measured the DES severity and defined DES as OSDI score ≥13. Current symptoms of DES and possible risk factors such as body mass index, occupatio
CYR61 could be an adjuvant biomarker associated with the inflammatory activity of GO.
PURPOSE: To report a case of visual loss associated with traumatic choroidal rupture after blunt ocular trauma that was successfully treated with an early intravitreal bevacizumab injection despite the absence of choroidal neovascularization (CNV). CASE REPORT: A 14-year-old boy presented with visual disturbance in his left eye after sustaining an ocular contusion 4 weeks earlier. The best-corrected visual acuity (BCVA) in the left eye was 20/50. Funduscopic examination revealed macular choroida
Aims To evaluate the clinical characteristics and causative genetic variants in autosomal optic atrophy diagnosed using next-generation sequencing (NGS). Methods A cohort of 57 unrelated families affected with bilateral optic atrophy were recruited from two university-based tertiary referral hospitals from May 2016 to April 2022. Genetic variants were detected using a target enrichment panel consisting of 429 or 595 genes and known deep intronic variants associated with inherited eye diseases, e
The lamina cribrosa was anteriorly displaced preoperatively, and its position was nearly unchanged after the surgery, especially in association with extraocular muscle enlargement. An enlarged extraocular muscle could reduce the pressure-relieving effect of orbital decompression around the scleral canal in patients with GO.
Spastic paraplegia is a neurodegenerative disorder characterized by progressive leg weakness and spasticity due to degeneration of corticospinal axons. SPG7 encodes paraplegin, and pathogenic variants in the gene cause hereditary spastic paraplegia as an autosomal recessive trait. Various ophthalmological findings including optic atrophy, ophthalmoplegia, or nystagmus have been reported in patients with spastic paraplegia type 7. We report a 15-year-old male patient with a novel heterozygous var
Dear Editor, We hereby present a case of paradoxical reaction after treatment of eyelid tuberculosis (TB) with anti-TB medication. An 89-year-old man presented with painful eyelid swelling and erythema of his left eyelid, which initially developed one month earlier (Fig. 1A); he was otherwise in a healthy condition. No history of ocular trauma or operation was reported. At the time of his first visit, his corrected vision was 20 / 20 (Snellen visual acuity) in the right and 20 / 40 in the lef
목적: 약물 이상반응의 임상 양상에 대한 조사는 종종 실시되어 왔으나, 중대한 약물 이상반응에 대한 분석을 집중적으로 한 경우는 국내에서 현재까지 보고되지 않았다. 이에중대한 약물 이상반응이 어떠한 임상 양상으로 발현되는지에 대해 구체적인 분석이 필요하다. 방법: 단일 3차 의료기관 지역의약품안전센터에서 수집한자료를 바탕으로, 인과성 평가를 완료한 후 2012년 3월부터2015년 11월까지 한국의약품 안전관리원에 보고한 사례 중에서 중대한 이상사례로 평가된 약물 부작용 사례(3,386사례)를 분석하였다. 결과: 계통별로 백혈구와 세망내피계가 511사례로 가장많았고, 일반적인 약물 이상반응에서 높은 빈도를 차지하는피부계통 병변과 소화기계 병변은 각각 296사례로 4번째, 216사례로 8번째였다. 단일 증상별로 백혈구감소증이 499사례(14.7%)로 가장 높았고, 저혈압이 444사례(13.1%), 그 다음이 아나필락시스 215사례(6.3%)였다. 백혈구감소증을 일으키는 약제 성분 중,