이병일 교수
Byung Il Lee
고려대학교 성형외과 · 의학
연구실 소개
이병일 교수의 연구실은 알츠하이머병의 핵심 병리인 아밀로이드 베타 단백질의 비정상적 응집을 억제하는 광활성 분자 기반 치료 전략과, 자기공명 전기임피던스 단층촬영(MREIT)을 활용한 고해상도 생체 전도도 영상 기술을 주요 연구 분야로 다룹니다. 특히 광자극을 이용한 단백질 응집 억제 메커니즘과 동물 모델에서의 신경 보호 효과, 그리고 유방 MREIT를 통한 조기 암 진단 기술 개발에 초점을 맞추고 있습니다. 연구는 분자생물학, 생체영상, 전기생리학을 융합하여 신약 개발과 진단 기술 혁신을 추구합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15The abnormal assembly of β-amyloid (Aβ) peptides into neurotoxic, β-sheet-rich amyloid aggregates is a major pathological hallmark of Alzheimer's disease (AD). Light-induced photosensitizing molecules can regulate Aβ amyloidogenesis. Multiple photochemical analyses using circular dichroism, atomic force microscopy, dot blot, and native gel electrophoresis verified that photoactivated meso-tetra(4-sulfonatophenyl)porphyrin (TPPS with M = 2H(+), Zn(2+), Cu(2+), Mn(2+)) successfully inhibits Aβ agg
In magnetic resonance electrical impedance tomography (MREIT), we try to reconstruct a cross-sectional resistivity (or conductivity) image of a subject. When we inject a current through surface electrodes, it generates a magnetic field. Using a magnetic resonance imaging (MRI) scanner, we can obtain the induced magnetic flux density from MR phase images of the subject. We use recessed electrodes to avoid undesirable artefacts near electrodes in measuring magnetic flux densities. An MREIT image r
In magnetic resonance electrical impedance tomography (MREIT) we inject currents through electrodes placed on the surface of a subject and try to reconstruct cross-sectional resistivity (or conductivity) images using internal magnetic flux density as well as boundary voltage measurements. In this paper we present a static resistivity image of a cubic saline phantom (50 x 50 x 50 mm3) containing a cylindrical sausage object with an average resistivity value of 123.7 ohms cm. Our current MREIT sys
In magnetic resonance electrical impedance tomography (MREIT), we inject electrical current into a volume conductor to induce a distribution of magnetic flux density. By measuring the internal magnetic flux density using an MR scanner, we reconstruct images of cross-sectional conductivity and current density distributions. One of the most important technical problems in MREIT is to reduce the noise level in the measured magnetic flux density data since it limits the quality of reconstructed imag
Abstract The abnormal assembly of β‐amyloid (Aβ) peptides into neurotoxic, β‐sheet‐rich amyloid aggregates is a major pathological hallmark of Alzheimer’s disease (AD). Light‐induced photosensitizing molecules can regulate Aβ amyloidogenesis. Multiple photochemical analyses using circular dichroism, atomic force microscopy, dot blot, and native gel electrophoresis verified that photoactivated meso ‐tetra(4‐sulfonatophenyl)porphyrin (TPPS with M=2H + , Zn 2+ , Cu 2+ , Mn 2+ ) successfully inhibit
We present a new medical imaging technique for breast imaging, breast MREIT, in which magnetic resonance electrical impedance tomography (MREIT) is utilized to get high-resolution conductivity and current density images of the breast. In this work, we introduce the basic imaging setup of the breast MREIT technique with an investigation of four different imaging configurations of current-injection electrode positions and pathways through computer simulation studies. Utilizing the preliminary find
To obtain optimum aesthetic result, perioral soft tissue defects require reconstruction using similar tissue. The submental area has very similar characteristics to perioral soft tissue and consists of thin, pliable tissue with a perfect color match. Therefore, we have used submental tissues for reconstruction of perioral soft tissue defects and application of the techniques, and results are discussed in this article. Between February 2001 and April 2008, 14 perioral soft tissue reconstruction p
Cross-sectional conductivity imaging in magnetic resonance electrical impedance tomography (MREIT) requires the measurement of internal magnetic flux density using an MRI scanner. Current injection MRI techniques have been used to induce magnetic flux density distributions that appear in phase parts of the obtained MR signals. Since any phase error, as well as noise, deteriorates the quality of reconstructed conductivity images, we must minimize them during the data acquisition process. In this
In MREIT, we reconstruct cross-sectional resistivity images of a subject. Injecting currents through surface electrodes, we measure internal magnetic flux density using MRCDI technique. Current density can be obtained from the magnetic flux density data. For resistivity image reconstruction algorithms, we need a three-dimensional forward solver computing voltage, current density, and magnetic flux density within the subject. Given injection currents as boundary conditions, the three-dimensional
Super junction trench gate power MOSFETs have been receiving attention in terms of the trade-off between breakdown voltage and on-resistance [1]. The vertical structure of super junction trench gate power MOSFETs allows the on-resistance to be reduced compared with conventional Trench Gate Power MOSFETs. The heat release of devices is also decreased with the reduction of on-resistance. In this paper, Lattice Temperature of two devices, Trench Gate Power MOSFET and Super junction trench gate powe
Photoexcited porphyrin molecules inhibit β-amyloid aggregation and rescue postsynaptlc toxicity and behavior defects in the Drosophila Alzheimer’s disease model under blue light. In their Communication on page 11472 ff., C. B. Park, K. Yu et al. present a chemical strategy for photodynamic suppression of β-amyloid aggregation using photosensitizing molecules. Photoexcited porphyrin molecules inhibit β-amyloid aggregation and rescue postsynaptlc toxicity and behavior defects in the Drosophila Alz
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