예병석 교수

ObjectiveaaTo investigate whether baseline olfactory dysfunction in Parkinson’s disease (PD) patients is associated with baselineand longitudinal motor and cognitive function. MethodsaaWe recruited 228 drug-naïve PD patients who were followed for a mean of 6 years. Patients underwent the Cross-CulturalSmell Identification Test (CCSIT), a neuropsychological test, and N-(3-[18F]fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane positron emission tomography within 6 months of the baseline ev

Firefighters have a high risk of developing cardiovascular and mental disorders due to their physical and chemical environments. However, in Korea, few studies have been conducted on environmental risk of firefighters. The Firefighter Research on the Enhancementof Safety and Health (FRESH) study aimed to discover the risk factors for cardiovascular disease and mental disordersamong firefighters. Former and current firefighters were recruited from three university hospitals. A total of 1022 parti

Purpose: We investigated the localizing and lateralizing values of auras in patients with lesional partial epilepsy on an outpatient basis. Materials and Methods: A total of 276 subjects were retrospectively selected for this study if they had a unilateral single lobar lesion based on magnetic resonance image (MRI) results, and their scalp electroencephalography (EEG) findings were not discordant with the MRI-defined lobar localization and lateralization. According to the lesion locations,subjec

Purpose: The aim of this study was to investigate the association between the changes in masticatory function and cognitive im pairment by analyzing longitudinal data of older Korean patients. Materials and Methods: Patients aged over 60 years with dental records between 2005 to 2010 (baseline; T1) and 2014 to 2020(follow-up; T2) were selected in a single medical center. Based on the dementia diagnosis after T2, the cohort was classified intotwo groups, the dementia group (n=122) and the control

<b><i>Background:</i></b> Amnestic mild cognitive impairment (aMCI) is regarded as a prodromal stage of Alzheimer’s disease (AD). Given that patients with early-onset AD (EOAD) and with late-onset AD (LOAD) are known to have different clinical courses, symptoms and neuroimaging findings, early-onset (EOMCI) and late-onset aMCI (LOMCI) might be expected to have similar differences as EOAD versus LOAD. <b><i>Methods:</i></b> Our study involving 425 patients with aMCI (124 EOMCI, 301 LOMCI), who we

<b><i>Background:</i></b> We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. <b><i>Methods:</i></b> A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk.

Purpose: Dementia and altered cognitive function are highly prevalent among older adults with mild cognitive impairment (MCI); hence, prevention is necessary before it develops into dementia. Treatment adherence—medication adherence and physical activity—is essential to prevent and delay dementia; however, comprehensive interventions to promote it in this population are lacking. This study aimed to develop a program for treatment adherence utilizing an Internet of things (IoT) device. Methods: T

배경 및 목적: 원발진행실어증(primary progressive aphasia, PPA)의 발화 생성 시 나타나는 쉼(pause)은 PPA 아형 분류 및 조기 진단을 위한 간단하고도 신뢰로운 바이오마커가 될 수 있다. 본 연구에서는 그림설명하기 과제를 통해 나타나는 PPA의 쉼의 특성을 살펴보고자 하였다. 방법: 연구 대상자는 의미형(semantic variant, 의미형) 9명, 발화부족형(logopenic variant, 발화부족형) 19명, 비유창형(nonfluent variant, 비유창형) 11명과 정상 대조군 21명을 포함하여 총 60명이었다. 대상자들이 산출한 발화는 전사 후, 음향학적 분석프로그램인 Praat을 사용하여 쉼 시간을 측정하였으며, 쉼 시간은 발화 간, 발화 내, 어절 간, 어절 내로 구분하였다. 결과: 비유창형은 의미형이나 발화부족형에 비해 발화 속도가 느리며, 발화 간 쉼 시간이 길었다. 한편, 발화부족형은 의미형에 비해 발화 내에서 위치한어절 간 쉼

Background and Purpose The associations between hearing loss (HL) and the mechanisms underlying cognitive impairment (CI) remain unclear. We evaluated the effects of clinical factors, vascular magnetic resonance imaging (MRI) markers, and CI mechanisms on HL. Methods In total, 112 patients with CI (59% demented) and subjective HL prospectively underwent MRI, amyloid positron-emission tomography (PET), hearing evaluations, and neuropsychological tests including a language comprehension test. Pati

배경 및 목적: 진행성 실어증은 서서히 나타나는 증상으로서, 환자의 의사소통 능력 변화를 가장 빨리 인식할 수 있는 사람은 환자의 보호자이다. 환자에게 적절한 중재를 제공하기 위해서 보호자 주호소를 분석할 필요가 있다. 방법: 제1단계에서 진행성 실어증 환자 44명(남:여=19:25, 평균 연령=70.5±10.14)의 전자의무기록(EMRs)을 활용하여 언어 관련 주호소를 정리하고, NVivo 1.0을 사용하여 주제 분석하였으며, 이를 바탕으로 45개 문항의 언어 설문지가 개발되었다. 제2단계에서 개발된 언어 설문지를 활용하여 보호자 9명(남:여=2:7. 평균 연령=56.5±12.82)에게 반구조화된 인터뷰를 실시하였으며, 인터뷰 내용을 주제 및 빈도 분석하였다. 결과: 주제 분석 결과, 총 6개의 상위 주제와 총 18개의 하위 주제가 도출되었다. 상위 주제는 ‘구어 표현’, ‘구어 이해’, ‘문어 표현’, ‘문어 이해’, ‘계산’, ‘말’이 포함되었다. 각 상위 주제에서 가장 빈번하