김철식 교수

Although the management status of obesity has improved during the recent years, more effective strategy to control obesity is needed.

BACKGROUND: We designed a system for diabetes patients treated with glargine, a long-acting insulin, to make an automatic adjustment of insulin dose based on glucose level data and to provide the patients with the needed insulin dose by using a short message service (SMS). We also compared diabetes patients who used our system with patients who received the conventional titration scheme. METHODS: Included were 100 type 2 diabetes patients whose blood glucose was suboptimally controlled on their

OBJECTIVE: Clinical aspects of diabetes and obesity are somewhat different, even at similar levels of insulin resistance. The purpose of this study was to determine differences in body fat distribution and serum adiponectin concentrations in diabetic and non-diabetic obese participants. We were also interested in identifying the characteristics of insulin resistance in these two groups, particularly from the standpoint of adiponectin. RESEARCH METHODS AND PROCEDURES: Adiponectin concentrations o

Incretin hormone-based therapy in type 2 diabetes has been widely used, and dipepdityl peptidase-4 (DPP-4) inhibitors, which prevent incretin degradation, have become popular oral hypoglycemic agents. The efficacy of DPP-4 inhibitors varies from individuals, and factors determining responses to DPP-4 inhibitors have not been fully established. We aimed to investigate whether genetic variations in glucagon-like peptide (GLP-1) receptor are associated with responses to DPP-4 inhibitors in patients

Lifelong strict self-care is essential in the management of diabetes, along with easy access to the health care system (1–3). However, there is an evident limitation in fulfilling these conditions in the current health care system, which is oriented toward outpatient care (4–7). Thus, various strategies have been designed to improve the quality and efficiency of treating diabetic patients. Wireless technology is a worldwide communication system that allows a person to contact others anywhere at

OBJECTIVE: Dyslipidaemia is a well-known manifestation of thyroid dysfunction. Recently, small low-density lipoprotein (LDL) particle size has been linked with development of cardiovascular disease. To better understand the effects of thyroid dysfunction on the development of cardiovascular disease, we examined LDL particle size and lipid profiles in subjects with different thyroid function. METHODS: Included were 46 patients with overt hypothyroidism, 57 patients with subclinical hypothyroidism

Central obesity with visceral fat accumulation and the amount of skeletal muscle mass may influence insulin sensitivity via its capacity for glucose load uptake. We investigated the relationships among the following metabolic variables: ratio of fat area to skeletal muscle area (VMR), percent ideal body weight, body mass index, waist-to-hip circumference (WHR) and visceral fat to subcutaneous fat ratio (VSR) in 114 nondiabetic middle-aged women. Anthropometric parameters, lipid profiles and sex

OBJECTIVE: Low birthweight is associated with insulin resistance later in life, and adiponectin is known to play an important role in insulin resistance. We have investigated whether birthweight has a relationship with adiponectin levels in adolescence. PATIENTS: An at-home questionnaire survey was completed by 660 middle-school students (aged 12-15 years) in Seoul, Korea, and 152 participants were selected randomly based on their birthweight. MEASUREMENTS Subjects were separated into three grou

Low birth weight is associated with insulin resistance and type 2 diabetes in adults. The fetal programming hypothesis has shown that insulin resistance and its associated metabolic disturbances result from a poor gestational environment, for which low birth weight is a surrogate. An at-home questionnaire survey was performed on 660 middle school students (12-15 years) in Seoul, Korea, and 152 cases were randomly selected based on their birth weight. Subjects were divided into three groups accor

본 연구는 현대자동차그룹의 중부유럽 생산법인과 함께 동반진출한 한국 부품업체들의 현지생산 네트워크 특성을 분석하는 것을 목적으로 한다. 본 연구에서는 동반진출 현지법인들에 대한 설문조사와 대면조사를 통해, 국내에서 형성된 고유한 생산 네트워크 특성이 중부유럽 현지에서 어떻게 구현되는지 변용과 복제라는 차원에서 규명하였다. 본 연구에 따르면, 우선 완성차업체와 동반진출 부품업체로 구성된 현지 생산네트워크는 구성에 있어 큰 변화를 보이지 않고 있는데, 이는 현지 부품업체에 대한 높은 진입장벽 혹은 제한성이 높다는 것을 의미한다. 또한 중부유럽 진출 부품업체들은 생산에 필요한 원자재와 부품들을 대부분 한국에서 수입하거나 현지에 동반진출한 또 다른 부품업체들로부터 조달받고 있으며, 자신이 생산한 품목을 대부분 현지 완성차 생산법인인 HMMC와 KMS에 납품함으로써 높은 전속성을 보이고 있다. 마지막으로 기존에 국내에서 형성된 매출, 고용, 임금의 계층성이 현지에서도 재현되고 있다. 이렇게

연구배경: 본 연구는 국민건강 영양조사자료(1998)를 토대로 우리나라 국민들의 당뇨병과 공복혈당장애의 유병률을 추정하고, 우리나라 국민들의 식사습관 및 과일섭취량을 조사함과 동시에, 식사습관 및 과일 등의 식품섭취량이 당뇨병 및 공복혈당장애의 유병률과의 관계를 분석하고자 실시하였다. 방법: 본 연구는 1998년 11월 1일에서 12월 30일까지 시행된 국민건강 영양조사 결과를 이용하였으며, 전국을 대표하는 12,189가구의 전체 가구원 39,331명 중 건강검진과 식품섭취조사를 실시한 8,166명을 대상으로 하였다. 결과: 본 연구의 결과는 다음과 같다. 1) 당뇨병과 공복혈당장애 유병률은 전체 자료에서 남·녀 모두에서 나이가 많을수록 높았고, 남자의 유병률이 여자보다 높았다. 공복혈당을 기준으로 분석한 당뇨병 유병률은 여자는 60~69세 군의 유병률이 15.9%로 가장 높았고, 남자는 50~59세 군에서 18.21%로 가장 높았으며, 공복혈당장애의 유병률은 여자는 70세 이상

Background: Some of the characteristic features of diabetes mellitus in Korea are that 70-80% of patients are non-obese or adult-onset type, and type 1 diabetes is very rare. Occasionally, autoantibodies to glutamic acid decarboxylase(GAD) are found in typical, type 2 diabetes mellitus patients(T2DM). The role of the autoantibody to GAD in T2DM is unknown. The aim of this study was to determine the clinical and biochemical characteristics between GAD-positive and GAD-negative non-obese, adult-on