김치영 교수

The incidence rate of NTM-PD in a tertiary referral hospital in South Korea continued to increase from 2006 to 2016. Furthermore, there were age- and sex-related differences in the clinical characteristics, which might contribute to understanding the nature of the disease and inherited and acquired host factors.

Introduction Favorable responses to the treatment including immune checkpoint inhibitors (ICIs) have been consistently reported in lung cancer with smoking history. As the tumor microenvironment (TME) may be involved in the treatment response to ICIs, we aimed to investigate the TME of lung cancer with different smoking status. Methods Lung adenocarcinoma (LUAD) tissue (Tu) and adjacent normal-appearing lung tissue (NL) from current and never smokers were investigated by single-cell RNA sequenci

In the general population, educational level of elementary school was an independent risk factor for COPD among the components comprising SES. Our results indicate that the implementation of preventive strategies for COPD in those with low educational status could be beneficial.

Confirmation of PH via preoperative cardiac catheterization was associated with the prognosis of the patient after LTX. Clinicians should consider the necessity for early transplantation surgery before the mPAP reaches ≥25 mmHg.

The incidence of MetS was higher in men with airflow obstruction than in healthy subjects.

AIM: Medications used for tuberculosis (TB) treatment are thought to increase uric acid levels and influence the occurrence of gout. The objective of this study was to evaluate the risk of gout in patients with TB. METHODS: We searched the South Korean National Health Claims database for incident cases of TB. After identifying patients diagnosed with gout within 6 months of TB diagnosis, the risk compared to the general population was estimated by calculating the standardized incidence ratios (S

Some genetic variants are associated with lung function decline and chronic obstructive pulmonary disease (COPD), but functional studies are necessary to confirm causality. We investigated the genetic susceptibility-associated lung function decline with or without COPD, using data from a community-based cohort (N = 8554). A genome-wide interaction study was conducted to identify the association between genetic variants and pulmonary function, and the way variants relate to lung impairment in acc

Background/Objectives Gastric cancer is the third most common cause of cancer-related deaths. Gastric cancer rates vary across regions, which may be attributable to factors such as Helicobacter pylori infection, environmental factors, and genetic predispositions. We examined the association between gastric cancer, nutrient intake, and lifestyle parameters in Korean adults. Methods This study utilized the KNHANES dataset (2012–2016) to explore the nutritional risk factors associated with gastric

Subsequent ICI use after platinum-based CC improved the overall survival rate of patients with advanced NSCLC. With the increasing burden of individual medical expenses, further research is required to identify patients for whom ICI treatment may be effective.

<title>Abstract</title> Background Significant differences exist between the toxicity and adverse outcomes of conventional cigarettes and electronic cigarettes (e-cigarettes). However, spirometry-based clinical outcomes analyses in the general population have not been widely studied. This study aimed to investigate the factors associated with e-cigarette use among individuals with different smoking statuses and pulmonary function test (PFT) results. Methods This study was conducted in Korea usin

Increasing the number of passes during EBUS-TBNA can maximize the diagnostic yield, especially when CT and/or PET/CT results are inconclusive.

Concurrent use of GASs with EGFR-TKIs is linked to poorer OS and PFS in patients with advanced NSCLC. Careful consideration is advised when prescribing GASs, including adjusting administration timing, minimizing overlap duration, or opting for H2RAs over PPIs. Further research is needed to optimize treatment protocols, specifically addressing the duration of overlap time, to improve patient outcomes.

This study indicates an association between e-cigarette use and individual factors, including sex, age, education level, and income level. Electronic cigarette use, including dual use, is associated with chronic obstructive pulmonary disease. Additionally, anxiety and depression were highest among dual users, followed by those among conventional cigarette users.

OBJECTIVE: To analyse the effects of tracheostomy timing on COVID-19 outcomes by comparing mortality rates at different time points (7, 10 and 14 days). DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, Embase, Cochrane Library, Web of Science and Scopus were searched from 31 August 2023 to 6 September 2023. PRIMARY AND SECONDARY OUTCOMES MEASURES: The primary outcome was short-term mortality, defined as intensive care unit (ICU) mortality, hospital mortality and 28-day or 30-da