장춘곤 교수
Choon Gon Jang
성균관대학교 약학과 · 신경과학
연구실 소개
장 춘 곤 교수의 연구실은 신경독성학과 염증 반응 조절 메커니즘을 중심으로, 환경 호르몬(예: BPA)과 천연물 추출물이 뇌 기능 및 정서 행동에 미치는 영향을 다룹니다. 특히, 미세글리아 세포에서의 염증 반응 억제 작용과 신경전달물질 수용체 기반의 정서 조절 메커니즘을 밝혀내는 데 초점을 맞추고 있으며, 불안, 우울, 기억 장애와 같은 정신신경질환의 생물학적 기반을 규명하고자 합니다. 이와 함께 약물의 보상 성질과 뇌 기능 변화 간의 연관성에 대해서도 기초 연구를 수행하고 있습니다.
환경 호르몬미세글리아염증 반응정서 행동뇌 기능
연구 현황
논문 수
343
총 인용 수
8,442
최근 5년 논문
38
주요 분야
신경과학
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
5개년 연도별 논문 게재 수
38총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
347총합
20212022202320242025
주요 논문
151
논문|인용수 431·2010
Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in miceSeung‐Hwan Kwon, Ha-Kyung Lee, Ji‐Ah Kim, Sa‐Ik Hong, Hyoung‐Chun Kim, Tae-Hyung Jo, Young-In Park, Chong‐Kil Lee, Yong-Bin Kim, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1European Journal of Pharmacology
PharmacologyMedicine
2
논문|인용수 193·2010
Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in miceYuhua Tian, Joung‐Hee Baek, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q4Synapse
Bisphenol A (BPA), an environmental endocrine-disrupting chemical, has been extensively evaluated for reproductive toxicity and carcinogenicity. However, little is known about the behavioral and neurochemical effects of BPA exposure. This study examined whether chronic daily exposure to an environmental endocrine-disrupting chemical, bisphenol A [(BPA); 100 microg/kg/day or 500 microg/kg/day, p.o.], from prenatal Day 7 to postnatal Day 36 would lead to changes in anxiety and memory in mice. Firs
Health, Toxicology and MutagenesisEnvironmental Science
3
논문|인용수 119·2011
Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cellsSeung‐Hwan Kwon, Ji‐Ah Kim, Sa‐Ik Hong, Yang‐Hee Jung, Hyoung‐Chun Kim, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q2Neurochemistry International
Plant ScienceAgricultural and Biological Sciences
4
논문|인용수 114·2009
Loganin improves learning and memory impairments induced by scopolamine in miceSeung‐Hwan Kwon, Hyoung‐Chun Kim, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1European Journal of Pharmacology
PharmacologyMedicine
5
논문|인용수 86·2007
Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomum cassia in miceHyun‐Sook Yu, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1Pharmacology Biochemistry and Behavior
Cellular and Molecular NeuroscienceNeuroscience
6
논문|인용수 82·2012
A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in ratsChoon‐Gon Jang, Tim Whitfield, Gery Schulteis, George F. Koob, Sunmee Wee
SJR Q1Psychopharmacology
Cellular and Molecular NeuroscienceNeuroscience
7
논문|인용수 80·2010
Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta25–35-induced learning and memory impairments in miceSeung‐Hwan Kwon, Ha-Kyung Lee, Ji‐Ah Kim, Sa‐Ik Hong, Kim Sun-Yeou, Tae-Hyung Jo, Young-In Park, Chong‐Kil Lee, Yong-Bin Kim, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q2Neuroscience Letters
PhysiologyMedicine
8
논문|인용수 76·2015
Involvement of the Nrf2/HO-1 signaling pathway in sulfuretin-induced protection against amyloid beta25–35 neurotoxicitySeung‐Hwan Kwon, Shi‐Xun Ma, Ji-Young Hwang, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q2Neuroscience
Molecular BiologyBiochemistry, Genetics and Molecular Biology
9
논문|인용수 74·2011
The neuroprotective effects of Lonicera japonica THUNB. against hydrogen peroxide-induced apoptosis via phosphorylation of MAPKs and PI3K/Akt in SH-SY5Y cellsSeung‐Hwan Kwon, Sa‐Ik Hong, Ji‐Ah Kim, Yang‐Hee Jung, Sun Yeou Kim, Hyoung‐Chun Kim, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1Food and Chemical Toxicology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
10
논문|인용수 72·2011
Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT1A, GABAA, and NMDA receptorsIn‐Jee You, Yang‐Hee Jung, Min‐Jung Kim, Seung‐Hwan Kwon, Sa‐Ik Hong, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1Neuropharmacology
Sensory SystemsNeuroscience
11
논문|인용수 63·2007
Antidepressant-like effects of Albizzia julibrissin in mice: Involvement of the 5-HT1A receptor systemJi‐Hyun Kim, Sun Yeou Kim, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1Pharmacology Biochemistry and Behavior
Cellular and Molecular NeuroscienceNeuroscience
12
논문|인용수 62·2010
Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in miceThi‐Lien Nguyen, Yun‐Sun Nam, Seok‐Yong Lee, H.-C. Kim, Choon‐Gon Jang
SJR Q1British Journal of AnaesthesiaOA
PhysiologyMedicine
13
논문|인용수 53·2015
3′,4′,7-Trihydroxyflavone prevents apoptotic cell death in neuronal cells from hydrogen peroxide-induced oxidative stressSeung‐Hwan Kwon, Sa‐Ik Hong, Shi‐Xun Ma, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1Food and Chemical Toxicology
NeurologyNeuroscience
14
논문|인용수 52·2017
Liquiritigenin ameliorates memory and cognitive impairment through cholinergic and BDNF pathways in the mouse hippocampusYong‐Hyun Ko, Seung‐Hwan Kwon, Seok‐Yong Lee, Choon‐Gon Jang
SJR Q1Archives of Pharmacal Research
PharmacologyPharmacology, Toxicology and Pharmaceutics
15
논문|인용수 51·2003
Differential effects of morphine and cocaine on locomotor activity and sensitization in μ-opioid receptor knockout miceJi‐Hoon Yoo, Eun Mi Yang, Seok‐Yong Lee, Horace H. Loh, Ing K. Ho, Choon‐Gon Jang
SJR Q2Neuroscience Letters
Cellular and Molecular NeuroscienceNeuroscience
대표 연구 분야
PharmacologyCellular and Molecular NeuroscienceMolecular BiologyNeurologyBiological PsychiatryPhysiology
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